Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

Plk4-dependent phosphorylation of STIL is required for centriole duplication

(2015) A.-S. Kratz et al.   Biology Open

Polo-like Kinase 4 Inhibition: A Strategy for Cancer Therapy?

(2014) Andrew J. Holland et al.   CANCER CELL

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

STIL Microcephaly Mutations Interfere with APC/C-Mediated Degradation and Cause Centriole Amplification

(2014) Christian Arquint et al.   CURRENT BIOLOGY

SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication

(2014) Chii Shyang Fong et al.   DEVELOPMENTAL CELL

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

(2014) H. Bazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

Stabilization of Cartwheel-less Centrioles for Duplication Requires CEP295-Mediated Centriole-to-Centrosome Conversion

(2014) Denisse Izquierdo et al.   Cell Reports

Structure of the SAS-6 cartwheel hub from Leishmania major

(2014) Mark van Breugel et al.   eLife

Polo-like Kinase 4 Autodestructs by Generating Its Slimb-Binding Phosphodegron

(2013) Joseph E. Klebba et al.   CURRENT BIOLOGY

Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number

(2013) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Direct Binding of SAS-6 to ZYG-1 Recruits SAS-6 to the Mother Centriole for Cartwheel Assembly

(2013) Molly M. Lettman et al.   DEVELOPMENTAL CELL

Loss of centrioles causes chromosomal instability in vertebrate somatic cells

(2013) Joo-Hee Sir et al.   JOURNAL OF CELL BIOLOGY

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

(2013) Radoslaw Laufer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress

(2013) Takanori Nakamura et al.   Nature Communications

Rapid Determination of Multiple Linear Kinase Substrate Motifs by Mass Spectrometry

(2012) Arminja N. Kettenbach et al.   CHEMISTRY & BIOLOGY

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

A Clinical Overview of Centrosome Amplification in Human Cancers

(2012) Jason Yongsheng Chan   International Journal of Biological Sciences

Cell-cycle-regulated expression of STIL controls centriole number in human cells

(2012) C. Arquint et al.   JOURNAL OF CELL SCIENCE

STIL is required for centriole duplication in human cells

(2012) J. Vulprecht et al.   JOURNAL OF CELL SCIENCE

Towards a molecular architecture of centriole assembly

(2012) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

(2012) Katharina F. Sonnen et al.   Biology Open

Structural Basis of the 9-Fold Symmetry of Centrioles

(2011) Daiju Kitagawa et al.   CELL

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

(2011) Chieh-Ju C Tang et al.   EMBO JOURNAL

Universal and Confident Phosphorylation Site Localization Using phosphoRS

(2011) Thomas Taus et al.   JOURNAL OF PROTEOME RESEARCH

Structures of SAS-6 Suggest Its Organization in Centrioles

(2011) M. van Breugel et al.   SCIENCE

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Centrioles: active players or passengers during mitosis?

(2010) Alain Debec et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DSas-6 and Ana2 Coassemble into Tubules to Promote Centriole Duplication and Engagement

(2010) Naomi R. Stevens et al.   DEVELOPMENTAL CELL

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

(2010) Onur Cizmecioglu et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

DrosophilaAna2 is a conserved centriole duplication factor

(2010) Naomi R. Stevens et al.   JOURNAL OF CELL BIOLOGY

Cep152 interacts with Plk4 and is required for centriole duplication

(2010) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Plk4 trans-autophosphorylation regulates centriole number by controlling  TrCP-mediated degradation

(2010) G. Guderian et al.   JOURNAL OF CELL SCIENCE

Asterless is a scaffold for the onset of centriole assembly

(2010) Nikola S. Dzhindzhev et al.   NATURE

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

(2009) S. Sur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Centrosome Dysfunction in Drosophila Neural Stem Cells Causes Tumors that Are Not Due to Genome Instability

(2008) Elisabeth Castellanos et al.   CURRENT BIOLOGY

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY