Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and targeted treatment of autoimmune and inflammatory diseases

Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout

(2020) Viola Klück et al.   ANNALS OF THE RHEUMATIC DISEASES

Erdheim‐Chester disease: An in vivo human model of Mϕ activation at the crossroad between chronic inflammation and cancer

(2020) Giulio Cavalli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Autophagy and Protein Secretion

(2020) Giulio Cavalli et al.   JOURNAL OF MOLECULAR BIOLOGY

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series

(2020) Achille Aouba et al.   ANNALS OF THE RHEUMATIC DISEASES

COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?

(2020) Serena Colafrancesco et al.   AUTOIMMUNITY REVIEWS

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

(2020) George Dimopoulos et al.   Cell Host & Microbe

Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic

(2020) Zahra Belhadjer et al.   CIRCULATION

Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study

(2020) Corrado Campochiaro et al.   European Journal of Internal Medicine

Use of anakinra in severe COVID-19: a case report

(2020) Giovanni Filocamo et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report

(2020) Marco Franzetti et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Safety and efficacy of early high-dose IV anakinra in severe COVID-19 lung disease

(2020) Emanuele Pontali et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

(2020) Lucio Verdoni et al.   LANCET

Resolution of Giant Coronary Aneurisms in a Child With Refractory Kawasaki Disease Treated With Anakinra

(2020) Alessandro Gambacorta et al.   Frontiers in Pediatrics

Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study

(2020) Emanuel Della-Torre et al.   ANNALS OF THE RHEUMATIC DISEASES

Successful treatment of severe COVID-19 with subcutaneous anakinra as a sole treatment

(2020) Andrés González-García et al.   RHEUMATOLOGY

Use of Anakinra to Prevent Mechanical Ventilation in Severe COVID‐19: A Case Series

(2020) Iris Navarro‐Millán et al.   Arthritis & Rheumatology

Targeting the Immune System for Pulmonary Inflammation and Cardiovascular Complications in COVID-19 Patients

(2020) Serena Colafrancesco et al.   Frontiers in Immunology

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

Role for nuclear interleukin-37 in the suppression of innate immunity

(2019) Suzhao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypes in Behçet’s syndrome

(2019) Emire Seyahi   Internal and Emergency Medicine

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

(2019) Laura C. Burzynski et al.   IMMUNITY

IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis

(2019) A. Gungl et al.   EUROPEAN RESPIRATORY JOURNAL

Behçet's Syndrome as a Model of Thrombo-Inflammation: The Role of Neutrophils

(2019) Giacomo Emmi et al.   Frontiers in Immunology

Developmentally Regulated Innate Immune NFκB Signaling Mediates IL-1α Expression in the Perinatal Murine Lung

(2019) Brittany Butler et al.   Frontiers in Immunology

The IL-1 family of cytokines and receptors in rheumatic diseases

(2019) Charles Anthony Dinarello   Nature Reviews Rheumatology

Anakinra for corticosteroid-dependent and colchicine-resistant pericarditis: The IRAP (International Registry of Anakinra for Pericarditis) study

(2019) Massimo Imazio et al.   European Journal of Preventive Cardiology

Neutralization of IL-1α ameliorates Crohn’s disease-like ileitis by functional alterations of the gut microbiome

(2019) Paola Menghini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating the Different Phenotypes of Behçet's Syndrome

(2019) Alessandra Bettiol et al.   Frontiers in Immunology

Behçet: the syndrome

(2019) Alessandra Bettiol et al.   RHEUMATOLOGY

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G

(2018) Eduardo J. Folco et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The use of interleukin 1 receptor antagonist (anakinra) in Kawasaki disease: A retrospective cases series

(2018) Isabelle Kone-Paut et al.   AUTOIMMUNITY REVIEWS

IL-1 receptor antagonist controls transcriptional signature of inflammation in patients with metastatic breast cancer

(2018) Te-Chia Wu et al.   CANCER RESEARCH

Simultaneous presence of hypercoagulation and increased clot lysis time due to IL-1β, IL-6 and IL-8

(2018) Janette Bester et al.   CYTOKINE

Interleukin-1 blockade in cardiovascular diseases: a clinical update

(2018) Leo F Buckley et al.   EUROPEAN HEART JOURNAL

Comparative analysis on the dynamic of lacrimal gland damage and regeneration after Interleukin-1α or duct ligation induced dry eye disease in mice

(2018) Jana Dietrich et al.   EXPERIMENTAL EYE RESEARCH

Management of idiopathic recurrent pericarditis in adults and in children: a role for IL-1 receptor antagonism

(2018) Antonio Brucato et al.   Internal and Emergency Medicine

Interleukin-37 Treatment of Mice with Metabolic Syndrome Improves Insulin Sensitivity and Reduces Pro-inflammatory Cytokine Production in Adipose Tissue

(2018) Dov B Ballak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

(2018) Samuel T. Montgomery et al.   Journal of Cystic Fibrosis

MABp1 Targeting IL-1α for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: A Randomized Study

(2018) Theodora Kanni et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interleukin 1 receptor antagonist (IL1RA ) gene polymorphism and levels associated with adverse outcome in severe community-acquired pneumonia in children: A hospital-based study in India

(2018) Shally Awasthi et al.   PEDIATRIC PULMONOLOGY

Redefining the ancestral origins of the interleukin-1 superfamily

(2018) Jack Rivers-Auty et al.   Nature Communications

Treating Heart Inflammation With Interleukin-1 Blockade in a Case of Erdheim–Chester Disease

(2018) Alessandro Tomelleri et al.   Frontiers in Immunology

Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation

(2018) Chloé Michaudel et al.   Frontiers in Immunology

Myocarditis: An Interleukin-1-Mediated Disease?

(2018) Giacomo De Luca et al.   Frontiers in Immunology

The fibrogenic chemokine CCL18 is associated with disease severity in Erdheim-Chester disease

(2018) Greta Pacini et al.   OncoImmunology

Treatment of Dilated Cardiomyopathy With Interleukin-1 Inhibition

(2018) Giacomo De Luca et al.   ANNALS OF INTERNAL MEDICINE

Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses

(2018) Sarang Tartey et al.   JOURNAL OF IMMUNOLOGY

An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication

(2018) Megan H. Orzalli et al.   MOLECULAR CELL

Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure

(2018) Mary K. Dahmer et al.   Pediatric Critical Care Medicine

Fluorouracil and bevacizumab plus anakinra for patients with metastatic colorectal cancer refractory to standard therapies (IRAFU): a single-arm phase 2 study

(2018) Nicolas Isambert et al.   OncoImmunology

Behçet's syndrome as a tool to dissect the mechanisms of thrombo-inflammation: clinical and pathogenetic aspects

(2018) M. Becatti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Vascular Behçet’s syndrome: an update

(2018) Giacomo Emmi et al.   Internal and Emergency Medicine

The Inter-Relationship of Platelets with Interleukin-1β-Mediated Inflammation in Humans

(2018) Rahajeng Tunjungputri et al.   THROMBOSIS AND HAEMOSTASIS

Anakinra Therapy for Non-cancer Inflammatory Diseases

(2018) Giulio Cavalli et al.   Frontiers in Pharmacology

Multicenter Study of a Novel Topical Interleukin-1 Receptor Inhibitor, Isunakinra, in Subjects With Moderate to Severe Dry Eye Disease

(2017) Michael H. Goldstein et al.   Eye & Contact Lens-Science and Clinical Practice

Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines

(2017) Danielle M. Clancy et al.   FEBS Journal

How stress contributes to autoimmunity-lessons from Sjögren's syndrome

(2017) Fotini N. Skopouli et al.   FEBS LETTERS

Function and regulation of IL-1α in inflammatory diseases and cancer

(2017) Ankit Malik et al.   IMMUNOLOGICAL REVIEWS

IL-1 and IL-1 regulatory pathways in cancer progression and therapy

(2017) Alberto Mantovani et al.   IMMUNOLOGICAL REVIEWS

Biology of IL-38 and its role in disease

(2017) Frank L. van de Veerdonk et al.   IMMUNOLOGICAL REVIEWS

Suppression of inflammation and acquired immunity by IL-37

(2017) Giulio Cavalli et al.   IMMUNOLOGICAL REVIEWS

Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8

(2017) Martina Molgora et al.   IMMUNOLOGICAL REVIEWS

High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

(2017) Marco E. Bianchi et al.   IMMUNOLOGICAL REVIEWS

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Reduction of Myocardial Ischemia–Reperfusion Injury by Inhibiting Interleukin-1 Alpha

(2017) Adolfo G. Mauro et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Alarmins: Feel the Stress

(2017) Peleg Rider et al.   JOURNAL OF IMMUNOLOGY

Adult leukoencephalopathies with prominent infratentorial involvement can be caused by Erdheim–Chester disease

(2017) Luisa Chiapparini et al.   JOURNAL OF NEUROLOGY

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study

(2017) Tamas Hickish et al.   LANCET ONCOLOGY

Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis

(2017) Federico Parisi et al.   MEDICINE

Acute Myocardial Infarction

(2017) Jeffrey L. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance

(2017) Giulio Cavalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interstitial lung disease in systemic sclerosis: current and future treatment

(2017) Roberto Giacomelli et al.   RHEUMATOLOGY INTERNATIONAL

Interleukin-1 Receptor Blockade Rescues Myocarditis-Associated End-Stage Heart Failure

(2017) Giulio Cavalli et al.   Frontiers in Immunology

Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress

(2016) Alberto López-Miguel et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Anakinra as efficacious therapy for 2 cases of intracranial Erdheim-Chester disease

(2016) E. L. Diamond et al.   BLOOD

Variability in the efficacy of the IL1 receptor antagonist anakinra for treating Erdheim-Chester disease

(2016) F. Cohen-Aubart et al.   BLOOD

Are neutrophilic dermatoses autoinflammatory disorders?

(2016) T.K. Satoh et al.   BRITISH JOURNAL OF DERMATOLOGY

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial)

(2016) Adriana H. Tremoulet et al.   Contemporary Clinical Trials

Treating Life-Threatening Myocarditis by Blocking Interleukin-1*

(2016) Giulio Cavalli et al.   CRITICAL CARE MEDICINE

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

(2016) Bita Shakoory et al.   CRITICAL CARE MEDICINE

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD

(2016) Emmanuel T. Osei et al.   EUROPEAN RESPIRATORY JOURNAL

Effect of Anakinra on Recurrent Pericarditis Among Patients With Colchicine Resistance and Corticosteroid Dependence

(2016) Antonio Brucato et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease

(2016) Martin Prince Alphonse et al.   JOURNAL OF IMMUNOLOGY

Interleukin 1α and the inflammatory process

(2016) Nelson C Di Paolo et al.   NATURE IMMUNOLOGY

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

(2016) Giulio Cavalli et al.   RHEUMATOLOGY

Macrophage activation syndrome complicating adult onset Still’s disease: A single center case series and comparison with literature

(2016) Aleksander Lenert et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice

(2016) Michela Terlizzi et al.   Oncotarget

Erratum: Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

(2016) Idan Cohen et al.   Scientific Reports

Safety and Efficacy of Anakinra in Severe Hidradenitis Suppurativa

(2016) Vassiliki Tzanetakou et al.   JAMA Dermatology

Plasma Chromogranin A as a marker of cardiovascular involvement in Erdheim–Chester disease

(2016) Elisabetta Ferrero et al.   OncoImmunology

Sjögren syndrome

(2016) Pilar Brito-Zerón et al.   Nature Reviews Disease Primers

Human Lung Cancer–Derived Immunosuppressive Plasmacytoid Dendritic Cells Release IL-1α in an AIM2 Inflammasome-Dependent Manner

(2015) Rosalinda Sorrentino et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse ModelSignificance

(2015) Youngho Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophil Activation Promotes Fibrinogen Oxidation and Thrombus Formation in Behçet's Disease

(2015) Matteo Becatti et al.   CIRCULATION

Interleukin-36α axis is modulated in patients with primary Sjögren's syndrome

(2015) F. Ciccia et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

2015 ESC Guidelines for the diagnosis and management of pericardial diseases

(2015) Yehuda Adler et al.   EUROPEAN HEART JOURNAL

Erdheim-Chester disease

(2015) Corrado Campochiaro et al.   European Journal of Internal Medicine

Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection

(2015) Nelson C. Di Paolo et al.   IMMUNITY

Formation of the inflammasome during cardiac allograft rejection

(2015) Keyur B. Shah et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer

(2015) David S. Hong et al.   INVESTIGATIONAL NEW DRUGS

IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs

(2015) Satoshi Nishimura et al.   JOURNAL OF CELL BIOLOGY

Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients

(2015) Liangliang Niu et al.   PLoS One

Neutrophilic dermatoses and autoinflammatory diseases with skin involvement—innate immune disorders

(2015) Alexander A. Navarini et al.   Seminars in Immunopathology

Associations between interleukin-1 polymorphisms and susceptibility to vasculitis: a meta-analysis

(2015) G.G. Song et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis

(2014) Yan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

(2014) A. C. Morton et al.   EUROPEAN HEART JOURNAL

Behçet’s syndrome pathophysiology and potential therapeutic targets

(2014) Giacomo Emmi et al.   Internal and Emergency Medicine

Formation of the inflammasome in acute myocarditis

(2014) Stefano Toldo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

(2014) Juliana Bessa et al.   JOURNAL OF AUTOIMMUNITY

Interleukin-1α neutralisation in patients with cancer

(2014) Charles Anthony Dinarello   LANCET ONCOLOGY

MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study

(2014) David S Hong et al.   LANCET ONCOLOGY

The inflammatory response in myocardial injury, repair and remodelling

(2014) Nikolaos G. Frangogiannis   Nature Reviews Cardiology

Effects of Interleukin-1 Blockade With Anakinra on Adverse Cardiac Remodeling and Heart Failure After Acute Myocardial Infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) Pilot Study]

(2013) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Diagnosing Erdheim–Chester disease

(2013) Giulio Cavalli et al.   ANNALS OF THE RHEUMATIC DISEASES

Anakinra treatment in patients with refractory inflammatory myopathies and possible predictive response biomarkers: a mechanistic study with 12 months follow-up

(2013) Mei Zong et al.   ANNALS OF THE RHEUMATIC DISEASES

The multifaceted clinical presentations and manifestations of Erdheim–Chester disease: comprehensive review of the literature and of 10 new cases

(2013) Giulio Cavalli et al.   ANNALS OF THE RHEUMATIC DISEASES

The heart on fire: inflammasome and cardiomyopathy

(2013) Antonio Abbate   EXPERIMENTAL PHYSIOLOGY

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

(2013) Marina Bersudsky et al.   GUT

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts

(2013) M I Suwara et al.   Mucosal Immunology

The Role of Interleukin-1 and Interleukin-18 in Pro-Inflammatory and Anti-Viral Responses to Rhinovirus in Primary Bronchial Epithelial Cells

(2013) Siân C. Piper et al.   PLoS One

Interleukin-1α

(2013) Peleg Rider et al.   SEMINARS IN IMMUNOLOGY

Negative regulatory receptors of the IL-1 family

(2013) Cecilia Garlanda et al.   SEMINARS IN IMMUNOLOGY

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

(2013) Busun Kim et al.   Frontiers in Immunology

Interleukin-1 and tumor necrosis factor α blockade treatment of experimental polymyositis in mice

(2012) Takahiko Sugihara et al.   ARTHRITIS AND RHEUMATISM

Interleukin-1α is the major alarmin of lung epithelial cells released during photodynamic therapy to induce inflammatory mediators in fibroblasts

(2012) E C Tracy et al.   BRITISH JOURNAL OF CANCER

Behçet Syndrome: Is It One Condition?

(2012) H. Yazici et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse

(2012) Stefano Toldo et al.   EXPERIMENTAL PHYSIOLOGY

Serum levels of interleukin-1α in patients with systemic sclerosis

(2012) Takeo Maekawa et al.   JOURNAL OF DERMATOLOGY

Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling

(2012) Seshagiri-Rao Nandula et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Third Universal Definition of Myocardial Infarction

(2012) Kristian Thygesen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

(2012) Jacques Banchereau et al.   NATURE IMMUNOLOGY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Endovascular aneurysm repair reverses the increased titer and the inflammatory activity of interleukin-1α in the serum of patients with abdominal aortic aneurysm

(2011) Clara M. Yates et al.   JOURNAL OF VASCULAR SURGERY

Hughes-Stovin Syndrome

(2011) Umair Khalid et al.   Orphanet Journal of Rare Diseases

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1 

(2011) Y. Berda-Haddad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

(2011) G. Caramori et al.   THORAX

Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

(2010) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Interleukin-1 as a Phenotypic Immunomodulator in Keratinizing Squamous Metaplasia of the Ocular Surface in Sjögren's Syndrome

(2010) Ying-Ting Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease

(2010) A. Aouba et al.   BLOOD

Platelet interleukin-1  drives cerebrovascular inflammation

(2010) P. Thornton et al.   BLOOD

IL-1B Polymorphism in Association With Initial Intravenous Immunoglobulin Treatment Failure in Taiwanese Children With Kawasaki Disease

(2010) Ken-Pen Weng et al.   CIRCULATION JOURNAL

IL-1: Discoveries, controversies and future directions

(2010) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-1 receptor-associated kinase M downregulates DSS-induced colitis†

(2010) Martin Berglund et al.   INFLAMMATORY BOWEL DISEASES

IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice

(2010) E. Voronov et al.   INTERNATIONAL IMMUNOLOGY

Epithelial Cells Promote Fibroblast Activation via IL-1α in Systemic Sclerosis

(2010) Nima Aden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function

(2010) Umesh S. Deshmukh et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1α stimulates proinflammatory cytokine expression in human cardiac myofibroblasts

(2009) Neil A. Turner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1β receptor antagonist (anakinra): An unrecognized autoinflammatory disease?

(2009) Paolo Picco et al.   ARTHRITIS AND RHEUMATISM

Role of cytokines and chemokines in idiopathic inflammatory myopathies

(2009) Boel De Paepe et al.   CURRENT OPINION IN RHEUMATOLOGY

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myocarditis

(2009) Leslie T. Cooper   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-1 Receptor Type I Signaling Critically Regulates Infarct Healing and Cardiac Remodeling

(2008) Marcin Bujak et al.   AMERICAN JOURNAL OF PATHOLOGY

Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma

(2008) Hangjun Duan et al.   ARTHRITIS AND RHEUMATISM

Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis

(2008) Ignatios Ikonomidis et al.   CIRCULATION

Constitutive Repression of Interleukin-1α in Endothelial Cells

(2008) Gregory J. Brunn et al.   CIRCULATION RESEARCH

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Neutrophilic Dermatoses in Children

(2008) David R. Berk et al.   PEDIATRIC DERMATOLOGY