☆ 4.6 Letter

Formation of the inflammasome during cardiac allograft rejection

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

期刊

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷 201, 期 -, 页码 328-330

出版社

ELSEVIER IRELAND LTD

DOI: 10.1016/j.ijcard.2015.08.070

关键词

Inflammasome; Myocarditis; Heart transplantation; Rejection

类别

Cardiac & Cardiovascular Systems

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Review Cardiac & Cardiovascular Systems

Heart transplantation: focus on donor recovery strategies, left ventricular assist devices, and novel therapies

Maria Generosa Crespo-Leiro, Maria Rosa Costanzo, Finn Gustafsson, Kiran K. Khush, Peter S. Macdonald, Luciano Potena, Josef Stehlik, Andreas Zuckermann, Mandeep R. Mehra

Summary: Heart transplantation faces challenges including limited organ pool, personalized immunosuppressive therapy, and minimizing late complications. Advances such as using hepatitis C-infected donors, expanding donor source, and new preservation techniques have increased organ availability. Mechanical circulatory support has helped patients with advanced heart failure maintain organ function while waiting for a suitable donor match.

EUROPEAN HEART JOURNAL (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Heart-After-Liver Transplantation Attenuates Rejection of Cardiac Allografts in Sensitized Patients

Richard C. Daly, Andrew N. Rosenbaum, Joseph A. Dearani, Alfredo L. Clavell, Naveen L. Pereira, Barry A. Boilson, Robert P. Frantz, Atta Behfar, Shannon M. Dunlay, Richard J. Rodeheffer, John A. Schirger, Timucin Taner, Manish J. Gandhi, Julie K. Heimbach, Charles B. Rosen, Brooks S. Edwards, Sudhir S. Kushwaha

Summary: This study demonstrates the successful transplantation using a heart-after-liver transplantation protocol, which provides profound immunologic protection and prevents adverse immunological outcomes in highly sensitized patients requiring combined heart-liver transplantation. The results show near-elimination of donor specific antibodies and minimal rejection episodes, leading to favorable long-term patient and graft outcomes.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Fulminant Giant Cell Myocarditis vs. Lymphocytic Myocarditis: A Comparison of Their Clinical Characteristics, Treatments, and Outcomes

Yuxiao Hu, Jie Ren, Xueqi Dong, Di Zhang, Yi Qu, Chunxue Yang, Yang Sun, Jinghui Li, Fang Luo, Wei Wang, Huanhuan Wang, Ping Qing, Shihua Zhao, Jie Huang, Litian Yu, Yaxin Liu, Huiqiong Tan

Summary: This study compared the clinical characteristics, treatments, and outcomes in patients with fulminant giant cell myocarditis (FGCM) and fulminant lymphocytic myocarditis (FLM). The results showed that patients with FGCM had milder inflammatory responses and myocardial damage compared to those with FLM, but had poorer prognoses. hs-CRP levels could serve as a promising prognostic biomarker and an appropriate cutoff point for differentiating between FGCM and FLM patients.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation

Fernando Lucas-Ruiz, Alejandro Penin-Franch, Jose Antonio Pons, Pablo Ramirez, Pablo Pelegrin, Santiago Cuevas, Alberto Baroja-Mazo

Summary: The NLRP3 inflammasome and pyroptosis play important roles in liver transplantation, affecting the progression of liver disease and treatment outcomes. Studying this pathway may lead to new strategies for the future treatment of LT.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Biology

Diagnostic and Prognostic Value of a TDI-Derived Systolic Wall Motion Analysis as a Screening Modality for Allograft Rejection after Heart Transplantation

Isabell A. Just, Meryem Guelfirat, Laura Leser, Ata Uecertas, Laurenz Kopp Fernandes, Maren Godde, Nicolas Merke, Philipp Stawowy, Felix Hennig, Christoph Knosalla, Volkmar Falk, Jan Knierim, Felix Schoenrath

Summary: This study investigated the diagnostic and prognostic value of using TDI-derived wall motion analysis as a screening modality in OHT aftercare. The results showed that Sm remained stable during the follow-up period, but reductions were associated with acute rejections and cardiac allograft vasculopathy. Lower Sm was linked to a higher all-cause mortality rate.

LIFE-BASEL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

A Review of Biomarkers of Cardiac Allograft Rejection: Toward an Integrated Diagnosis of Rejection

Guillaume Coutance, Eva Desire, Jean-Paul Duong Van Huyen

Summary: Despite advances in immunosuppression, allograft rejection remains a significant complication after heart transplantation. The current invasive diagnostic method has limitations, thus innovative strategies are needed to improve the accuracy of diagnosis.

BIOMOLECULES (2022)

添加到收藏夹

Article Ophthalmology

Kaempferol alleviates corneal transplantation rejection by inhibiting NLRP3 inflammasome activation and macrophage M1 polarization via promoting autophagy

Huiwen Tian, Shumei Lin, Jing Wu, Ming Ma, Jian Yu, Yuanping Zeng, Qi Liu, Linjiang Chen, Jing Xu

Summary: Kaempferol inhibits NLRP3 inflammasome activation by inducing autophagy, thereby inhibiting macrophage polarization and ultimately alleviating corneal transplantation rejection.

EXPERIMENTAL EYE RESEARCH (2021)

添加到收藏夹

Review Food Science & Technology

NLRP3 Inflammasome: A key contributor to the inflammation formation

Wen-Juan Zhang, Ke-Yun Li, Yi Lan, Han-Yi Zeng, Shui-Qin Chen, Hui Wang

Summary: Inflammation is a crucial factor in the development of organ diseases, and the NLRP3 inflammasome is the most well-studied inflammasome. The NLRP3 inflammasome is composed of NLRP3, ASC, and pro-caspase-1. It can be activated through classical, non-canonical, and alternative pathways, and its activation is involved in various inflammatory diseases. Factors such as genetics, environment, chemicals, and viral infections can activate the NLRP3 inflammasome and promote inflammation in organs. However, the mechanisms and effects of NLRP3 inflammation in different cells and tissues are still not fully understood.

FOOD AND CHEMICAL TOXICOLOGY (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Size matching in combined heart-lung transplant: An undersized predicted heart mass is associated with increased mortality

Ahad Firoz, Roh Yanagida, Mohammed Kashem, Yoshiya Toyoda

Summary: This study retrospectively analyzed the impact of donor-recipient organ size matching on survival and graft rejection outcomes in combined heart-lung transplantation. The results showed that matching based on predicted heart mass ratio (pHM ratio) can reduce the risk of mortality associated with organ size mismatch.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

添加到收藏夹

Article Environmental Sciences

Sema3A alleviates viral myocarditis by modulating SIRT1 to regulate cardiomyocyte mitophagy

Lin Lin, Jin Wei, Canzhan Zhu, Guanghua Hao, Jiahong Xue, Yanhe Zhu, Ruiyun Wu

Summary: Viral myocarditis (VMC) is an inflammatory disease that leads to cardiomyocyte damage. In this study, the researchers found that Sema3A, a protein, can reduce cardiac dysfunction and tissue inflammation in a VMC mouse model. They also discovered that Sema3A promotes cardiomyocyte mitophagy and suppresses inflammasome activation by regulating SIRT1, thereby protecting cardiomyocytes from macrophage-induced damage.

ENVIRONMENTAL TOXICOLOGY (2023)

添加到收藏夹

Article Immunology

Single-cell analysis of graft-infiltrating host cells identifies caspase-1 as a potential therapeutic target for heart transplant rejection

Zhichao Wu, Jialiang Liang, Shuoji Zhu, Nanbo Liu, Mingyi Zhao, Fei Xiao, Guanhua Li, Changjiang Yu, Chengyu Jin, Jinshan Ma, Tucheng Sun, Ping Zhu

Summary: This study investigates the cellular composition of graft-infiltrating cells during the early rejection stage at a single-cell level and identifies potential therapeutic targets. The results highlight the crucial role of caspase-1 in interferon-mediated inflammatory monocytes infiltrating heart transplants, suggesting its potential as a therapeutic target for attenuating rejection.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Article Materials Science, Multidisciplinary

Microneedle-mediated transdermal delivery of FK506 for treatment of acute cardiac allograft rejection

Cheng Deng, Chenyuan Wang, Wenpei Fu, Lujuan Wu, Qiaofeng Jin, Li Zhang, Wen Zhang, Wei Li, Mingxing Xie

Summary: This study evaluated the efficacy of a FK506-loaded microneedle (FK506 MN) in treating acute rejection in heart transplantation. The results showed that FK506 MN could successfully alleviate acute rejection and prolong allograft survival. In addition, it also reduced T cell and macrophage infiltration as well as the secretion of certain cytokines.

MATERIALS & DESIGN (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The impact of induction therapy on mortality and treated rejection in cardiac transplantation: A retrospective study

Lavanya Bellumkonda, Evangelos K. Oikonomou, Christine Hsueh, Christopher Maulion, Jeffrey Testani, Jignesh Patel

Summary: This study investigated the impact of induction therapy on heart transplantation patients. The results showed that TC-DA induction therapy was associated with a reduced risk of treated rejection at one year, but had no effect on mortality. On the other hand, IL2 receptor antagonist induction therapy was associated with a small but statistically significant increase in mortality, without impacting the risk of rejection.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Circulating microRNAs in cellular and antibody- mediated heart transplant rejection

Palak Shah, Sean Agbor-Enoh, Pramita Bagchi, Christopher R. deFilippi, Angela Mercado, Gouqing Diao, Dave J. P. Morales, Keyur B. Shah, Samer S. Najjar, Erika Feller, Steven Hsu, Maria E. Rodrigo, Sabra C. Lewsey, Moon Kyoo Jang, Charles Marboe, Gerald J. Berry, Kiran K. Khush, Hannah A. Valantine, GRAfT Investigators

Summary: By analyzing and studying miR expression data in heart transplant patients, miR panels with high diagnostic accuracy for acute rejection can be developed, providing a new non-invasive method for clinical monitoring of heart transplant.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Many heart transplant biopsies currently diagnosed as no rejection have mild molecular antibody-mediated rejection-related changes

Philip F. Halloran, Katelynn Madill-Thomsen, Arezu Z. Aliabadi-Zuckermann, Martin Cadeiras, Marisa G. Crespo-Leiro, Eugene C. Depasquale, Mario Deng, Johannes Gokler, Daniel H. Kim, Jon Kobashigawa, Peter Macdonald, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann

Summary: This study extended the MMDx system to classify heart transplant endomyocardial biopsies into a new Minor category characterized by low-level inflammation and ABMR-related gene expression. The results suggest that low-level ABMR-related molecular stress may be operating in more hearts than previously estimated.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

添加到收藏夹

Review Peripheral Vascular Disease

Atherothrombosis Prevention and Treatment with Anti-interleukin-1 Agents

Giuseppe Biondi-Zoccai, Cristian M. Garmenda, Antonio Abbate, Arturo Giordano, Giacomo Frati, Sebastiano Sciarretta, Barbara Antonazzo, Francesco Versaci

CURRENT ATHEROSCLEROSIS REPORTS (2020)

添加到收藏夹

Editorial Material Peripheral Vascular Disease

Inflammation and Hypertension Causal or Not?

Dave L. Dixon, George F. Wohlford, Antonio Abbate

HYPERTENSION (2020)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Minerva Cardioangiologica: glancing backward, rushing forward

Giuseppe Biondi Zoccai, Antonio Abbate, Giacomo Frati, Mario Gaudino, Enrico Romagnoli, Sebastiano Sciarretta

MINERVA CARDIOANGIOLOGICA (2020)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

COLCOT and CANTOS: piecing together the puzzle of inflammation and cardiovascular events

George F. Wohlford, Benjamin W. Van Tassell, Krishna Ravindra, Antonio Abbate

MINERVA CARDIOANGIOLOGICA (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Cardiovascular Implications of the COVID-19 Pandemic: A Global Perspective

Marouane Boukhris, Ali Hillani, Francesco Moroni, Mohamed Salah Annabi, Faouzi Addad, Marcelo Harada Ribeiro, Samer Mansour, Xiaohui Zhao, Luiz Fernando Ybarra, Antonio Abbate, Luz Maria Vilca, Lorenzo Azzalini

CANADIAN JOURNAL OF CARDIOLOGY (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

Antonio Abbate, Stefano Toldo, Carlo Marchetti, Jordana Kron, Benjamin W. Van Tassell, Charles A. Dinarello

CIRCULATION RESEARCH (2020)

添加到收藏夹

Article Endocrinology & Metabolism

The effects of canagliflozin compared to sitagliptin on cardiorespiratory fitness in type 2 diabetes mellitus and heart failure with reduced ejection fraction: TheCANA-HFstudy

Salvatore Carbone, Hayley E. Billingsley, Justin M. Canada, Edoardo Bressi, Brando Rotelli, Dinesh Kadariya, Dave L. Dixon, Roshanak Markley, Cory R. Trankle, Richard Cooke, Krishnasree Rao, Keyur B. Shah, Horacio Medina de Chazal, Juan Guido Chiabrando, Alessandra Vecchie, Megan Dell, Virginia L. Mihalick, Roberta Bogaev, Linda Hart, Benjamin W. Van Tassell, Ross Arena, Francesco S. Celi, Antonio Abbate

DIABETES-METABOLISM RESEARCH AND REVIEWS (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardiovascular Considerations in Treating Patients With Coronavirus Disease 2019 (COVID-19)

Dave L. Dixon, Benjamin W. Van Tassell, Alessandra Vecchie, Aldo Bonaventura, Azita H. Talasaz, Hessam Kakavand, Fabrizio D'Ascenzo, Antonio Perciaccante, Davide Castagno, Enrico Ammirati, Giuseppe Biondi-Zoccai, Michael P. Stevens, Antonio Abbate

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Acute Effects of Interleukin-1 Blockade Using Anakinra in Patients With Acute Pericarditis

George F. Wohlford, Leo F. Buckley, Alessandra Vecchie, Dinesh Kadariya, Roshanak Markley, Cory R. Trankle, Juan Guido Chiabrando, Horacio Medina de Chazal, Benjamin Van Tassell, Antonio Abbate

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Stenting techniques for coronary bifurcation lesions: Evidence from a network meta-analysis of randomized clinical trials

Juan G. Chiabrando, Marco Lombardi, Giovanni M. Vescovo, George F. Wohlford, Rachel A. Koenig, Antonio Abbate, Luis A. Guzman, Daniel H. Berrocal, Giuseppe Biondi-Zoccai

Summary: In this network meta-analysis, DK crush and Mini-crush were associated with fewer events and complications compared to other techniques, including the Provisional approach. However, Culotte and Crush were found to have a higher risk of stent thrombosis compared to the Provisional approach.

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2021)

添加到收藏夹

Article Cell Biology

Change in Eosinophil Count in Patients with Heart Failure Treated with Anakinra

Michele Golino, Francesco Moroni, Marco Giuseppe Del Buono, Justin M. M. Canada, Azita H. H. Talasaz, Sebastian Pinel, James Mbualungu, Alessandra Vecchie, Ai-Chen (Jane) Ho, Georgia K. Thomas, Salvatore Carbone, Hayley E. Billingsley, Jeremy Turlington, Roshanak Markley, Cory Trankle, Roberto De Ponti, Benjamin Van Tassell, Antonio Abbate

Summary: Anakinra treatment leads to a transient increase in eosinophils in patients with heart failure, which is associated with injection site reactions and improvement in cardiorespiratory fitness.

CELLS (2023)

添加到收藏夹

Meeting Abstract Cardiac & Cardiovascular Systems

A CASE OF GIANT LEFT ATRIUM DUE TO A FAILED MITRAL VALVE ANNULOPLASTY

Jay Park, Aaron Schatz, Jaideep Patel, Zackary Tushak, Antonio Abbate, Hem Bhardwaj, Barbara Lawson, Zachary Gertz

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

添加到收藏夹

Meeting Abstract Cardiac & Cardiovascular Systems

HYPERTENSION GUIDELINES AND CORONARY ARTERY CALCIFICATION AMONG SOUTH ASIANS: MEDIATORS OF ATHEROSCLEROSIS IN SOUTH ASIANS LIVING IN AMERICA (MASALA) AND MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)

Jaideep Patel, Anurag Mehta, Mahmoud Al Rifai, Michael Blaha, Khurram Nasir, John W. McEvoy, Ambarish Pandey, Alka Kanaya, Namratha R. Kandula, Salim S. Virani, Antonio Abbate, William G. Hundley, Laurence S. Sperling, Parag Joshi

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

添加到收藏夹

Meeting Abstract Cardiac & Cardiovascular Systems

HOW AN IMAGE CAN SOLVE THE CASE: RARE SOURCE OF INTRACARDIAC EMBOLI

Zackary Tushak, Jaideep Patel, Aaron Schatz, Rajiv Ashok Kabadi, Taha Al-Jubaishi, Taeshik Park, Antonio Abbate, Phoebe Ashley

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

添加到收藏夹

Meeting Abstract Cardiac & Cardiovascular Systems

NEWLY IDENTIFIED MUTATION OF ABCC9 POTASSIUM CHANNEL IN A PATIENT WITH RECURRENT EXERTION INDUCED POLYMORPHIC VENTRICULAR TACHYCARDIA

Zackary Tushak, April Shewmake, Jaideep Patel, Ajay Pillai, Jordana Kron, Santosh Kumar Padala, Krishnasree Rao, Allison Goodwin, Antonio Abbate

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.