标题
The IL-1 family of cytokines and receptors in rheumatic diseases
作者
关键词
-
出版物
Nature Reviews Rheumatology
Volume 15, Issue 10, Pages 612-632
出版商
Springer Science and Business Media LLC
发表日期
2019-09-12
DOI
10.1038/s41584-019-0277-8
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure
- (2019) Brendan M. Everett et al. CIRCULATION
- Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro
- (2019) Dongping Zhang et al. JOURNAL OF NEUROSCIENCE RESEARCH
- A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis
- (2019) Roy M. Fleischmann et al. Arthritis & Rheumatology
- Interleukin-37 monomer is the active form for reducing innate immunity
- (2019) Elan Z. Eisenmesser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential
- (2019) Marie-Astrid Boutet et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
- (2019) Fan Zhang et al. NATURE IMMUNOLOGY
- Interleukin-36 in Infectious and Inflammatory Skin Diseases
- (2019) Anna-Lena Buhl et al. Frontiers in Immunology
- IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease
- (2019) Jesper Falkesgaard Højen et al. NATURE IMMUNOLOGY
- The use of interleukin 1 receptor antagonist (anakinra) in Kawasaki disease: A retrospective cases series
- (2018) Isabelle Kone-Paut et al. AUTOIMMUNITY REVIEWS
- Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome
- (2018) Eric S. Weiss et al. BLOOD
- Usefulness and safety of anakinra in refractory Kawasaki disease complicated by coronary artery aneurysm
- (2018) Marie-Paule Guillaume et al. CARDIOLOGY IN THE YOUNG
- Anakinra treatment in macrophage activation syndrome: a single center experience and systemic review of literature
- (2018) Hafize Emine Sönmez et al. CLINICAL RHEUMATOLOGY
- Elevated frequency of IL-37- and IL-18Rα-positive T cells in the peripheral blood of rheumatoid arthritis patients
- (2018) Liuqing Wang et al. CYTOKINE
- Gene Delivery to Joints by Intra-Articular Injection
- (2018) Christopher H. Evans et al. HUMAN GENE THERAPY
- Gasdermin D Flashes an Exit Signal for IL-1
- (2018) Teneema Kuriakose et al. IMMUNITY
- The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
- (2018) Charles L. Evavold et al. IMMUNITY
- Role of Interleukin 37 as a Novel Proangiogenic Factor in Juvenile Idiopathic Arthritis
- (2018) Amal Mohamad El-Barbary et al. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
- Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface
- (2018) Fiona Moghaddas et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Interleukin-37 Treatment of Mice with Metabolic Syndrome Improves Insulin Sensitivity and Reduces Pro-inflammatory Cytokine Production in Adipose Tissue
- (2018) Dov B Ballak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interleukin 38 Protects Against Lethal Sepsis
- (2018) Fang Xu et al. JOURNAL OF INFECTIOUS DISEASES
- MABp1 Targeting IL-1α for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: A Randomized Study
- (2018) Theodora Kanni et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes
- (2018) Brendan M. Everett et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
- (2018) Carlo Marchetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases
- (2018) Graeme P. Sullivan et al. Cell Death & Disease
- Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation
- (2018) Graeme P. Sullivan et al. FEBS Open Bio
- Relationship of Interleukin-1β Blockade With Incident Gout and Serum Uric Acid Levels
- (2018) Daniel H. Solomon et al. ANNALS OF INTERNAL MEDICINE
- Elevated Interleukin-38 Level Associates with Clinical Response to Atorvastatin in Patients with Hyperlipidemia
- (2018) Ning Yang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Elevated levels of IL-37 correlate with T cell activation status in rheumatoid arthritis patients
- (2018) Dina Ragab et al. CYTOKINE
- High Interleukin-37 (IL-37) Expression and Increased Mucin-Domain Containing-3 (TIM-3) on Peripheral T Cells in Patients with Rheumatoid Arthritis
- (2018) Lijun Song et al. MEDICAL SCIENCE MONITOR
- Prolonged treatment with Tadekinig alfa in adult-onset Still’s disease
- (2018) Uta Kiltz et al. ANNALS OF THE RHEUMATIC DISEASES
- Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis
- (2018) Margreet Kloppenburg et al. ANNALS OF THE RHEUMATIC DISEASES
- Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis
- (2018) Zhu Chen et al. Nature Reviews Rheumatology
- Low-Dose Methotrexate for the Prevention of Atherosclerotic Events
- (2018) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anakinra for the treatment of acute gout flares: a randomized, double-blind, placebo-controlled, active-comparator, non-inferiority trial
- (2018) Carly A Janssen et al. RHEUMATOLOGY
- Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
- (2018) Pontus Orning et al. SCIENCE
- The Inter-Relationship of Platelets with Interleukin-1β-Mediated Inflammation in Humans
- (2018) Rahajeng Tunjungputri et al. THROMBOSIS AND HAEMOSTASIS
- IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment
- (2018) Laura Mercurio et al. Cell Death & Disease
- Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways
- (2018) Claudia Semino et al. Cell Death & Disease
- Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice
- (2018) Jianqiu Xiao et al. PLOS BIOLOGY
- Anakinra Therapy for Non-cancer Inflammatory Diseases
- (2018) Giulio Cavalli et al. Frontiers in Pharmacology
- Biologic drugs in adult onset Still’s disease: a systematic review and meta-analysis of observational studies
- (2017) Piero Ruscitti et al. Expert Review of Clinical Immunology
- Canakinumab for the treatment of familial Mediterranean fever
- (2017) Huri Ozdogan et al. Expert Review of Clinical Immunology
- IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor
- (2017) Sebastian Günther et al. IMMUNITY
- In vivo anti-inflammatory activities of novel cytokine IL-38 in Murphy Roths Large (MRL)/lpr mice
- (2017) Man Chu et al. IMMUNOBIOLOGY
- Biology of IL-38 and its role in disease
- (2017) Frank L. van de Veerdonk et al. IMMUNOLOGICAL REVIEWS
- Regulation and function of interleukin-36 cytokines
- (2017) Esen Yonca Bassoy et al. IMMUNOLOGICAL REVIEWS
- Suppression of inflammation and acquired immunity by IL-37
- (2017) Giulio Cavalli et al. IMMUNOLOGICAL REVIEWS
- The family of the interleukin-1 receptors
- (2017) Diana Boraschi et al. IMMUNOLOGICAL REVIEWS
- Interleukin-18: Biological properties and role in disease pathogenesis
- (2017) Gilles Kaplanski IMMUNOLOGICAL REVIEWS
- Overview of the IL-1 family in innate inflammation and acquired immunity
- (2017) Charles A. Dinarello IMMUNOLOGICAL REVIEWS
- The NLRC4 Inflammasome
- (2017) Joseph A. Duncan et al. IMMUNOLOGICAL REVIEWS
- Efficacy and safety of canakinumab in Schnitzler syndrome: A multicenter randomized placebo-controlled study
- (2017) Karoline Krause et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition
- (2017) Scott W. Canna et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Pathways of impending disease flare in African-American systemic lupus erythematosus patients
- (2017) Melissa E. Munroe et al. JOURNAL OF AUTOIMMUNITY
- An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β
- (2017) David Brough et al. JOURNAL OF CELL SCIENCE
- A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis
- (2017) Alma-Martina Cepika et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Alarmins: Feel the Stress
- (2017) Peleg Rider et al. JOURNAL OF IMMUNOLOGY
- Interleukin-1 Beta as a Target for Atherosclerosis Therapy
- (2017) Peter Libby JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial
- (2017) Paul M Ridker et al. LANCET
- MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study
- (2017) Tamas Hickish et al. LANCET ONCOLOGY
- Ethanol-mediated suppression of IL-37 licenses alcoholic liver disease
- (2017) Felix Grabherr et al. LIVER INTERNATIONAL
- Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis
- (2017) Federico Parisi et al. MEDICINE
- IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
- (2017) Martina Molgora et al. NATURE
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study
- (2017) S.X. Wang et al. OSTEOARTHRITIS AND CARTILAGE
- Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ
- (2017) Joseph S. Ainscough et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice
- (2017) Qingchun Zeng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance
- (2017) Giulio Cavalli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway
- (2017) Tania O. Crişan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Canakinumab for first line steroid-free treatment in a child with systemic-onset juvenile idiopathic arthritis
- (2017) G Horneff et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Adult onset Still’s disease—The evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review)
- (2017) Guido Junge et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- Effects of Aging in Multisensory Integration: A Systematic Review
- (2017) Alix L. de Dieuleveult et al. Frontiers in Aging Neuroscience
- Response to Interleukin-1 Inhibitors in 140 Italian Patients with Adult-Onset Still’s Disease: A Multicentre Retrospective Observational Study
- (2017) Serena Colafrancesco et al. Frontiers in Pharmacology
- Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis
- (2017) Sonia Nasi et al. Frontiers in Pharmacology
- Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes
- (2017) Julia Lachner et al. Scientific Reports
- Reduction in C-reactive protein indicates successful targeting of the IL-1/IL-6 axis resulting in improved survival in early stage multiple myeloma
- (2016) John A. Lust et al. AMERICAN JOURNAL OF HEMATOLOGY
- Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease–Associated Abdominal Aortic AneurysmSignificance
- (2016) Daiko Wakita et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Host and Environmental Factors Influencing Individual Human Cytokine Responses
- (2016) Rob ter Horst et al. CELL
- Distinct expression of interleukin (IL)-36α, βandγ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease
- (2016) M.-A. Boutet et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Interleukin (IL)-1 inhibition with anakinra and canakinumab in Behçet’s disease-related uveitis: a multicenter retrospective observational study
- (2016) Claudia Fabiani et al. CLINICAL RHEUMATOLOGY
- Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial)
- (2016) Adriana H. Tremoulet et al. Contemporary Clinical Trials
- Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome
- (2016) Bita Shakoory et al. CRITICAL CARE MEDICINE
- Suppression of innate inflammation and immunity by interleukin-37
- (2016) Charles A. Dinarello et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Canakinumab investigated for treating familial Mediterranean fever
- (2016) Ruby Haviv et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-α, IL-β, IL-6 and IL-17A
- (2016) Rihab Charrad et al. IMMUNOBIOLOGY
- Pharmacokinetics and Tolerability of a Dual Variable Domain Immunoglobulin ABT-981 Against IL-1α and IL-1β in Healthy Subjects and Patients With Osteoarthritis of the Knee
- (2016) Matthew P. Kosloski et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Interleukin-37 suppresses tumor growth through inhibition of angiogenesis in non-small cell lung cancer
- (2016) Guanqun Ge et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- In Vivo Expansion of Activated Foxp3+Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis
- (2016) Jérôme Biton et al. JOURNAL OF IMMUNOLOGY
- Adjunctive therapies for Kawasaki disease
- (2016) Anita J. Campbell et al. JOURNAL OF INFECTION
- Anti-interleukin-1 treatment in 26 patients with refractory familial mediterranean fever
- (2016) Orhan Kucuksahin et al. Modern Rheumatology
- Interleukin 1α and the inflammatory process
- (2016) Nelson C Di Paolo et al. NATURE IMMUNOLOGY
- Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation
- (2016) Giulio Cavalli et al. RHEUMATOLOGY
- Elevated serum levels of free interleukin-18 in adult-onset Still’s disease
- (2016) Charlotte Girard et al. RHEUMATOLOGY
- Elevated serum interleukin-38 level at baseline predicts virological response in telbivudine-treated patients with chronic hepatitis B
- (2016) Hong-Juan Wang WORLD JOURNAL OF GASTROENTEROLOGY
- Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses
- (2016) Javier Mora et al. Journal of Molecular Cell Biology
- Safety and Efficacy of Anakinra in Severe Hidradenitis Suppurativa
- (2016) Vassiliki Tzanetakou et al. JAMA Dermatology
- A Snapshot on the On-Label and Off-Label Use of the Interleukin-1 Inhibitors in Italy among Rheumatologists and Pediatric Rheumatologists: A Nationwide Multi-Center Retrospective Observational Study
- (2016) Antonio Vitale et al. Frontiers in Pharmacology
- IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice
- (2015) L. Lunding et al. ALLERGY
- Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra
- (2015) Leo A B Joosten et al. ANNALS OF THE RHEUMATIC DISEASES
- Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra
- (2015) Tania O Crișan et al. ANNALS OF THE RHEUMATIC DISEASES
- Pathogenesis of Macrophage Activation Syndrome and Potential for Cytokine- Directed Therapies
- (2015) Grant S. Schulert et al. Annual Review of Medicine
- Elevated serum levels of Interleukin-37 are associated with inflammatory cytokines and disease activity in rheumatoid arthritis
- (2015) Libin Yang et al. APMIS
- Emerging clinical phenotypes associated with anti-cytokine autoantibodies
- (2015) Thierry Vincent et al. AUTOIMMUNITY REVIEWS
- Interleukin-36α axis is modulated in patients with primary Sjögren's syndrome
- (2015) F. Ciccia et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Elevated serum and synovial fluid levels of interleukin-37 in patients with rheumatoid arthritis: Attenuated the production of inflammatory cytokines
- (2015) Liping Xia et al. CYTOKINE
- Interleukin-37 gene variants segregated anciently coexist during hominid evolution
- (2015) Bin Kang et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Interleukin-37 expression is decreased in Behçet's disease and is associated with inflammation
- (2015) Eya Bouali et al. IMMUNOLOGY LETTERS
- Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer
- (2015) David S. Hong et al. INVESTIGATIONAL NEW DRUGS
- Expression of IL-36 family cytokines and IL-37 but not IL-38 is altered in psoriatic skin
- (2015) Maris Keermann et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β
- (2015) Susan E Lacy et al. mAbs
- IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
- (2015) Claudia A Nold-Petry et al. NATURE IMMUNOLOGY
- Interleukin-1 function and role in rheumatic disease
- (2015) Georg Schett et al. Nature Reviews Rheumatology
- Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey
- (2015) Linda Rossi-Semerano et al. Orphanet Journal of Rare Diseases
- Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8
- (2015) Suzhao Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
- (2015) Michael J. Ombrello et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-33 and soluble ST2 levels as novel predictors for remission and progression of carotid plaque in early rheumatoid arthritis: A prospective study
- (2015) Jiayun Shen et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- The role of interleukin-1 beta in the pathophysiology of Schnitzler’s syndrome
- (2015) Heleen D. de Koning et al. ARTHRITIS RESEARCH & THERAPY
- Open-Label Trial of MABp1, a True Human Monoclonal Antibody Targeting Interleukin 1α, for the Treatment of Psoriasis
- (2015) Kyle M. Coleman et al. JAMA Dermatology
- Ability of Interleukin-33- and Immune Complex-Triggered Activation of Human Mast Cells to Down-Regulate Monocyte-Mediated Immune Responses
- (2015) Felice Rivellese et al. Arthritis & Rheumatology
- Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes
- (2015) Heba M. Ismail et al. Arthritis & Rheumatology
- Brief Report: Interleukin-38 Exerts Antiinflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus
- (2015) Ina Rudloff et al. Arthritis & Rheumatology
- Interleukin-18 mediates interleukin-1-induced cardiac dysfunction
- (2014) Stefano Toldo et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- IFN- causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation
- (2014) F.-c. Lin et al. BLOOD
- Anakinra treatment in patients with gout and type 2 diabetes
- (2014) Antonio Vitale et al. CLINICAL RHEUMATOLOGY
- A Possible Role for Interleukin 37 in the Pathogenesis of Behcet's Disease
- (2014) Z. Ye et al. CURRENT MOLECULAR MEDICINE
- Association of Interleukin 1 Family with Systemic Sclerosis
- (2014) Li Zhang et al. INFLAMMATION
- Interleukin-1 blockade in rheumatoid arthritis and heart failure: A missed opportunity?
- (2014) Antonio Abbate et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation
- (2014) Juliana Bessa et al. JOURNAL OF AUTOIMMUNITY
- Levels of interleukin-37 in gingival crevicular fluid, saliva, or plasma in periodontal disease
- (2014) M. Sağlam et al. JOURNAL OF PERIODONTAL RESEARCH
- MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study
- (2014) David S Hong et al. LANCET ONCOLOGY
- An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
- (2014) Scott W Canna et al. NATURE GENETICS
- Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells
- (2014) Yuchun Luo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The structural basis for receptor recognition of human interleukin-18
- (2014) Naotaka Tsutsumi et al. Nature Communications
- IL-37 protects against obesity-induced inflammation and insulin resistance
- (2014) Dov B. Ballak et al. Nature Communications
- Clinical Features, Treatment, and Outcome of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A Multinational, Multicenter Study of 362 Patients
- (2014) Francesca Minoia et al. Arthritis & Rheumatology
- Resistant Behçet Disease Responsive to Anakinra
- (2013) Costantino Botsios et al. ANNALS OF INTERNAL MEDICINE
- Anakinra treatment in patients with refractory inflammatory myopathies and possible predictive response biomarkers: a mechanistic study with 12 months follow-up
- (2013) Mei Zong et al. ANNALS OF THE RHEUMATIC DISEASES
- Interferon-γ Mediates Anemia but Is Dispensable for Fulminant Toll-like Receptor 9-Induced Macrophage Activation Syndrome and Hemophagocytosis in Mice
- (2013) Scott W. Canna et al. ARTHRITIS AND RHEUMATISM
- Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency
- (2013) Taizo Wada et al. CYTOKINE
- Canakinumab in pediatric rheumatic diseases
- (2013) Nico M Wulffraat et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Interleukin-18 gene polymorphisms and rheumatoid arthritis: A meta-analysis
- (2013) Jong Dae Ji et al. GENE
- Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation
- (2013) Yue Zheng et al. IMMUNITY
- The Interleukin-1 Family: Back to the Future
- (2013) Cecilia Garlanda et al. IMMUNITY
- Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis
- (2013) Steven M. Opal et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Uric acid, chronic kidney disease and type 2 diabetes: A cluster of vascular risk factors
- (2013) Vasilios G. Athyros et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis
- (2013) Arrigo F.G. Cicero et al. JOURNAL OF HYPERTENSION
- Refractory macrophage activation syndrome in a patient with SLE and APLA syndrome – Successful use of PET- CT and Anakinra in its diagnosis and treatment
- (2013) Oshrat E. Tayer-Shifman et al. Modern Rheumatology
- Structural insights into the interaction of IL-33 with its receptors
- (2013) X. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Treating inflammation by blocking interleukin-1 in humans
- (2013) Charles A. Dinarello et al. SEMINARS IN IMMUNOLOGY
- Interleukin-1α
- (2013) Peleg Rider et al. SEMINARS IN IMMUNOLOGY
- Negative regulatory receptors of the IL-1 family
- (2013) Cecilia Garlanda et al. SEMINARS IN IMMUNOLOGY
- Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency
- (2013) Praxedis Martin et al. ARTHRITIS RESEARCH & THERAPY
- A genetic role for macrophage migration inhibitory factor (MIF) in adult-onset Still's disease
- (2013) Fang-Fang Wang et al. ARTHRITIS RESEARCH & THERAPY
- Correlation between single nucleotide polymorphism of rs3811047 in IL-1 F7 gene and rheumatoid arthritis susceptibility among Han population in central plains of China
- (2013) Li-Pu Shi et al. Asian Pacific Journal of Tropical Medicine
- The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
- (2013) David Gustafsson et al. BMC Nephrology
- IL-1 Trap rilonacept in refractory adult onset Still's disease
- (2012) Olga Petryna et al. ANNALS OF THE RHEUMATIC DISEASES
- Canakinumab for acute gouty arthritis in patients with limited treatment options: results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions
- (2012) Naomi Schlesinger et al. ANNALS OF THE RHEUMATIC DISEASES
- Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome
- (2012) Heleen D de Koning et al. ANNALS OF THE RHEUMATIC DISEASES
- Interleukin-1 and tumor necrosis factor α blockade treatment of experimental polymyositis in mice
- (2012) Takahiko Sugihara et al. ARTHRITIS AND RHEUMATISM
- IL-36 in psoriasis
- (2012) JE Towne et al. CURRENT OPINION IN PHARMACOLOGY
- Serum cytokine profile in patients with active lupus nephritis
- (2012) Katrin Franzika Koenig et al. CYTOKINE
- Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes
- (2012) C. Cavelti-Weder et al. DIABETES CARE
- Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment
- (2012) A Ravelli et al. GENES AND IMMUNITY
- Associations of theIL-1F7gene polymorphisms with rheumatoid arthritis in Chinese Han population
- (2012) B. Pei et al. International Journal of Immunogenetics
- IL-33 regulates TNF-α dependent effects in synovial fibroblasts
- (2012) ELKE KUNISCH et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Glucocorticoid Regulates Interleukin-37 in Systemic Lupus Erythematosus
- (2012) Lijun Song et al. JOURNAL OF CLINICAL IMMUNOLOGY
- IL-33: A Novel Danger Signal System in Atopic Dermatitis
- (2012) Ferda Cevikbas et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
- (2012) Charles A. Dinarello et al. NATURE REVIEWS DRUG DISCOVERY
- Structure of the activating IL-1 receptor signaling complex
- (2012) Christoph Thomas et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
- (2012) F. L. van de Veerdonk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
- (2012) E. Lefrancais et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phase 2 enzyme inducer sulphoraphane blocks prostaglandin and nitric oxide synthesis in human articular chondrocytes and inhibits cartilage matrix degradation
- (2012) H.-A. Kim et al. RHEUMATOLOGY
- TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity
- (2012) Federica Riva et al. Frontiers in Immunology
- Mutations in IL36RN/IL1F5 Are Associated with the Severe Episodic Inflammatory Skin Disease Known as Generalized Pustular Psoriasis
- (2011) Alexandros Onoufriadis et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behçet's disease: an open-label pilot study
- (2011) Ahmet Gül et al. ANNALS OF THE RHEUMATIC DISEASES
- Familial and Acquired Hemophagocytic Lymphohistiocytosis
- (2011) G.E. Janka Annual Review of Medicine
- Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
- (2011) Jelena Vojinovic et al. ARTHRITIS AND RHEUMATISM
- A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features
- (2011) Nicolino Ruperto et al. ARTHRITIS AND RHEUMATISM
- IL-36R ligands are potent regulators of dendritic and T cells
- (2011) S. Vigne et al. BLOOD
- Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, phase II, dose-finding study
- (2011) Rieke Alten et al. BMC MUSCULOSKELETAL DISORDERS
- Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
- (2011) Abbas Dehghan et al. CIRCULATION
- IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+T cells
- (2011) Qianting Yang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity
- (2011) Jennifer E. Towne et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-1 and IL-1 Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation
- (2011) P. Rider et al. JOURNAL OF IMMUNOLOGY
- Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis
- (2011) Yeon-Sik Hong et al. JOURNAL OF KOREAN MEDICAL SCIENCE
- Unknown
- (2011) Antonio Furlan et al. MOLECULAR MEDICINE
- Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis
- (2011) Slaheddine Marrakchi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Global metabolic profiling of human osteoarthritic synovium
- (2011) S.B. Adams et al. OSTEOARTHRITIS AND CARTILAGE
- Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1
- (2011) Y. Berda-Haddad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sustained elevation of interleukin-33 in sera and synovial fluids from patients with rheumatoid arthritis non-responsive to anti-tumor necrosis factor: possible association with persistent IL-1β signaling and a poor clinical response
- (2011) Yasushi Matsuyama et al. RHEUMATOLOGY INTERNATIONAL
- A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
- (2011) Stanley B Cohen et al. ARTHRITIS RESEARCH & THERAPY
- A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)
- (2010) P. Quartier et al. ANNALS OF THE RHEUMATIC DISEASES
- Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
- (2010) Leo A. B. Joosten et al. ARTHRITIS AND RHEUMATISM
- Why not treat human cancer with interleukin-1 blockade?
- (2010) Charles A. Dinarello CANCER AND METASTASIS REVIEWS
- Autoinflammatory Disease Reloaded: A Clinical Perspective
- (2010) Daniel L. Kastner et al. CELL
- Macrophage activation syndrome: advances towards understanding pathogenesis
- (2010) Alexei A Grom et al. CURRENT OPINION IN RHEUMATOLOGY
- Cytokine Profiles of Macrophage Activation Syndrome Associated with Rheumatic Diseases
- (2010) J. MARUYAMA et al. JOURNAL OF RHEUMATOLOGY
- Structural insights into the assembly and activation of IL-1β with its receptors
- (2010) Dongli Wang et al. NATURE IMMUNOLOGY
- IL-37 is a fundamental inhibitor of innate immunity
- (2010) Marcel F Nold et al. NATURE IMMUNOLOGY
- Low innate production of interleukin-1β and interleukin-6 is associated with the absence of osteoarthritis in old age
- (2010) R.J. Goekoop et al. OSTEOARTHRITIS AND CARTILAGE
- Differential release of chromatin-bound IL-1 discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
- (2010) I. Cohen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis
- (2010) M. Shimizu et al. RHEUMATOLOGY
- A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis
- (2010) Mario H Cardiel et al. ARTHRITIS RESEARCH & THERAPY
- IL-18 Activity in Systemic Lupus Erythematosus
- (2009) Flavia Favilli et al. Annals of the New York Academy of Sciences
- The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study
- (2009) R Terkeltaub et al. ANNALS OF THE RHEUMATIC DISEASES
- Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
- (2009) Seth L. Masters et al. Annual Review of Immunology
- Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis
- (2009) Gaby Palmer et al. ARTHRITIS AND RHEUMATISM
- Inflammatory arthritis in caspase 1 geneâdeficient mice: Contribution of proteinase 3 to caspase 1âindependent production of bioactive interleukin-1β
- (2009) Leo A. B. Joosten et al. ARTHRITIS AND RHEUMATISM
- Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study
- (2009) X. Chevalier et al. ARTHRITIS AND RHEUMATISM
- Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS)
- (2009) Hal M Hoffman EXPERT OPINION ON BIOLOGICAL THERAPY
- High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein
- (2009) Daniela Novick et al. JOURNAL OF AUTOIMMUNITY
- In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes
- (2009) Helen J. Lachmann et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response
- (2009) K. Bulek et al. JOURNAL OF IMMUNOLOGY
- Pyroptosis: host cell death and inflammation
- (2009) Tessa Bergsbaken et al. NATURE REVIEWS MICROBIOLOGY
- Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome
- (2009) Helen J. Lachmann et al. NEW ENGLAND JOURNAL OF MEDICINE
- The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
- (2009) C. Cayrol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phase 2 enzyme inducer sulphoraphane blocks matrix metalloproteinase production in articular chondrocytes
- (2009) H. Ah Kim et al. RHEUMATOLOGY
- Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes
- (2009) Andreas Lingel et al. STRUCTURE
- Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 by mononuclear cells through a caspase 1-mediated process
- (2008) E J Giamarellos-Bourboulis et al. ANNALS OF THE RHEUMATIC DISEASES
- Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice
- (2008) Marije I. Koenders et al. ARTHRITIS AND RHEUMATISM
- The pattern of response to anti–interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis
- (2008) Marco Gattorno et al. ARTHRITIS AND RHEUMATISM
- Differential requirement for the activation of the inflammasome for processing and release of IL-1 in monocytes and macrophages
- (2008) M. G. Netea et al. BLOOD
- Interleukin-18 Binding Protein in the Sera of Patients with Wegener’s Granulomatosis
- (2008) D. Novick et al. JOURNAL OF CLINICAL IMMUNOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now