IL-1 and IL-1 regulatory pathways in cancer progression and therapy

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

(2017) Wen Pan et al.   IMMUNITY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

(2017) Martina Molgora et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer

(2016) Maria Rosaria Galdiero et al.   INTERNATIONAL JOURNAL OF CANCER

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Regulatory Role of IL-1R8 in Immunity and Disease

(2016) Martina Molgora et al.   Frontiers in Immunology

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

(2015) Claudia A Nold-Petry et al.   NATURE IMMUNOLOGY

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

(2015) Suzhao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis

(2014) Kepeng Wang et al.   IMMUNITY

MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study

(2014) David S Hong et al.   LANCET ONCOLOGY

The role IL-1 in tumor-mediated angiogenesis

(2014) Elena Voronov et al.   Frontiers in Physiology

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

MyD88 and its divergent toll in carcinogenesis

(2013) Rosalba Salcedo et al.   TRENDS IN IMMUNOLOGY

IL-1R–MyD88 signaling in keratinocyte transformation and carcinogenesis

(2012) Christophe Cataisson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

The growing diversity and spectrum of action of myeloid-derived suppressor cells

(2010) Alberto Mantovani   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function

(2010) Moshe Elkabets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Host-Derived Interleukin-1  Is Important in Determining the Immunogenicity of 3-Methylcholantrene Tumor Cells

(2009) M. Elkabets et al.   JOURNAL OF IMMUNOLOGY

The Role of Macrophage-Derived IL-1 in Induction and Maintenance of Angiogenesis

(2009) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1β-Induced Interleukin 6 Production and the Myeloma Proliferative Component

(2009) John A. Lust et al.   MAYO CLINIC PROCEEDINGS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE