An ER translocon for multi-pass membrane protein biogenesis

Structural basis for membrane insertion by the human ER membrane protein complex

(2020) Tino Pleiner et al.   SCIENCE

Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking and activity of the nonselective cation channel TRPC6

(2019) Brianna E. Talbot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites

(2019) Natalia A. Cherepanova et al.   JOURNAL OF CELL BIOLOGY

TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling

(2019) Jianwei Li et al.   Nature Communications

Distance-based protein folding powered by deep learning

(2019) Jinbo Xu   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex

(2019) Songhai Tian et al.   Cell Reports

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum

(2018) Katharina Braunger et al.   SCIENCE

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy

(2018) Khampaseuth Thapa et al.   Cell and Bioscience

Bi-allelic CCDC47 Variants Cause a Disorder Characterized by Woolly Hair, Liver Dysfunction, Dysmorphic Features, and Global Developmental Delay

(2018) Marie Morimoto et al.   AMERICAN JOURNAL OF HUMAN GENETICS

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis

(2018) Norbert Volkmar et al.   JOURNAL OF CELL SCIENCE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Structure and allosteric inhibition of excitatory amino acid transporter 1

(2017) Juan C. Canul-Tec et al.   NATURE

Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

(2017) Stefan Schoebel et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum

(2017) S. Andrei Anghel et al.   Cell Reports

Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model

(2017) Sheng Wang et al.   PLoS Computational Biology

Diagnostic Yield and Novel Candidate Genes by Exome Sequencing in 152 Consanguineous Families With Neurodevelopmental Disorders

(2017) Miriam S. Reuter et al.   JAMA Psychiatry

TMCO1 Is an ER Ca 2+ Load-Activated Ca 2+ Channel

(2016) Qiao-Chu Wang et al.   CELL

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of a substrate-engaged SecY protein-translocation channel

(2016) Long Li et al.   NATURE

YidC assists the stepwise and stochastic folding of membrane proteins

(2016) Tetiana Serdiuk et al.   Nature Chemical Biology

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis

(2016) Alexej Kedrov et al.   Cell Reports

Global, quantitative and dynamic mapping of protein subcellular localization

(2016) Daniel N Itzhak et al.   eLife

Mechanisms of Integral Membrane Protein Insertion and Folding

(2015) Florian Cymer et al.   JOURNAL OF MOLECULAR BIOLOGY

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events

(2015) Brian J. Conti et al.   MOLECULAR CELL

Structure of the human 80S ribosome

(2015) Heena Khatter et al.   NATURE

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

A YidC-like Protein in the Archaeal Plasma Membrane

(2015) Marta T. Borowska et al.   STRUCTURE

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity

(2014) Shinichiro Yamamoto et al.   DEVELOPMENTAL BIOLOGY

NRA-2, a Nicalin Homolog, Regulates Neuronal Death by Controlling Surface Localization of ToxicCaenorhabditis elegansDEG/ENaC Channels

(2014) Shaunak Kamat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of Sec-independent membrane protein insertion by YidC

(2014) Kaoru Kumazaki et al.   NATURE

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

(2014) Fei Wang et al.   NATURE

TMCO1 deficiency causes autosomal recessive cerebrofaciothoracic dysplasia

(2013) Yasemin Alanay et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Whole-exome sequencing identified a patient with TMCO1 defect syndrome and expands the phenotic spectrum

(2013) AO Caglayan et al.   CLINICAL GENETICS

Matching Cross-linked Peptide Spectra: Only as Good as the Worse Identification

(2013) Michael J. Trnka et al.   MOLECULAR & CELLULAR PROTEOMICS

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Expanding the Chemical Cross-Linking Toolbox by the Use of Multiple Proteases and Enrichment by Size Exclusion Chromatography

(2012) Alexander Leitner et al.   MOLECULAR & CELLULAR PROTEOMICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Calumin, a Ca2+-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca2+ release-activated Ca2+ (CRAC) channels

(2011) Masakazu Konno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

(2011) Kathryn P Burdon et al.   NATURE GENETICS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex

(2010) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of M3 Muscarinic Receptor Expression and Function by Transmembrane Protein 147

(2010) E. Rosemond et al.   MOLECULAR PHARMACOLOGY

An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse

(2009) Ruta B Almedom et al.   EMBO JOURNAL

Cellular mechanisms of membrane protein folding

(2009) William R Skach   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Homozygous frameshift mutation in TMCO1 causes a syndrome with craniofacial dysmorphism, skeletal anomalies, and mental retardation

(2009) B. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

The Pf3 coat protein contacts TM1 and TM3 of YidC during membrane biogenesis

(2008) Christian Klenner et al.   FEBS LETTERS

The Conserved Third Transmembrane Segment of YidC Contacts NascentEscherichia coliInner Membrane Proteins

(2008) Zhong Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY