The ER membrane protein complex is a transmembrane domain insertase

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

(2017) Sarah Haßdenteufel et al.   FEBS LETTERS

Mechanistic basis for a molecular triage reaction

(2017) Sichen Shao et al.   SCIENCE

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum

(2017) S. Andrei Anghel et al.   Cell Reports

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

(2016) Eisuke Itakura et al.   MOLECULAR CELL

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

Multiple selection filters ensure accurate tail-anchored membrane protein targeting

(2016) Meera Rao et al.   eLife

Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo

(2016) Jhon Rivera-Monroy et al.   Scientific Reports

Structure of the Get3 targeting factor in complex with its membrane protein cargo

(2015) A. Mateja et al.   SCIENCE

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

(2015) Takunori Satoh et al.   eLife

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

(2014) Fei Wang et al.   NATURE

A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria

(2014) Sujoy Lahiri et al.   PLOS BIOLOGY

Deubiquitinases Sharpen Substrate Discrimination during Membrane Protein Degradation from the ER

(2013) Zai-Rong Zhang et al.   CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

(2013) Magali Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis

(2012) Raymond J Louie et al.   Genome Medicine

A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins

(2011) Sichen Shao et al.   CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

(2011) S. Stefer et al.   SCIENCE

A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic Reticulum

(2010) Fei Wang et al.   MOLECULAR CELL

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Functional Depletion of Mahogunin by Cytosolically Exposed Prion Protein Contributes to Neurodegeneration

(2009) Oishee Chakrabarti et al.   CELL

Strong Correlation Between Statistical Transmembrane Tendency and Experimental Hydrophobicity Scales for Identification of Transmembrane Helices

(2009) Gang Zhao et al.   JOURNAL OF MEMBRANE BIOLOGY

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE