The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

Defining the physiological role of SRP in protein-targeting efficiency and specificity

(2018) Elizabeth A. Costa et al.   SCIENCE

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

(2017) Xiaofang Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Performance Evaluation of the Q Exactive HF-X for Shotgun Proteomics

(2017) Christian D. Kelstrup et al.   JOURNAL OF PROTEOME RESEARCH

Transcriptome-wide measurement of translation by ribosome profiling

(2017) Nicholas J. McGlincy et al.   METHODS

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum

(2017) S. Andrei Anghel et al.   Cell Reports

A Proteomics Approach to the Protein Normalization Problem: Selection of Unvarying Proteins for MS-Based Proteomics and Western Blotting

(2016) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

(2016) Rong Zhang et al.   NATURE

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

EMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy

(2016) X Shen et al.   Cell Death & Disease

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus

(2016) Parikshit Bagchi et al.   eLife

Global, quantitative and dynamic mapping of protein subcellular localization

(2016) Daniel N Itzhak et al.   eLife

Mechanisms of Integral Membrane Protein Insertion and Folding

(2015) Florian Cymer et al.   JOURNAL OF MOLECULAR BIOLOGY

A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

(2015) Hongming Ma et al.   Cell Reports

Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast

(2015) Jeffrey A. Hussmann et al.   PLoS Genetics

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

(2015) Takunori Satoh et al.   eLife

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria

(2014) Sujoy Lahiri et al.   PLOS BIOLOGY

A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial

(2014) Michael P Boyle et al.   Lancet Respiratory Medicine

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

(2013) Magali Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy

(2012) Yanjun Li et al.   Autophagy

1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data

(2012) Juergen Cox et al.   BMC BIOINFORMATICS

A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis

(2012) Raymond J Louie et al.   Genome Medicine

Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis

(2011) Peter W. Bircham et al.   Molecular BioSystems

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling

(2011) G. A. Brar et al.   SCIENCE

A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties

(2010) Hayley J. Sharpe et al.   CELL

Precision Mapping of an In Vivo N-Glycoproteome Reveals Rigid Topological and Sequence Constraints

(2010) Dorota F. Zielinska et al.   CELL

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Niemann-Pick Type C1 I1061T Mutant Encodes a Functional Protein That Is Selected for Endoplasmic Reticulum-associated Degradation Due to Protein Misfolding

(2008) Mark E. Gelsthorpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA interference screen for human genes associated with West Nile virus infection

(2008) Manoj N. Krishnan et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY