标题
GDF15, an update of the physiological and pathological roles it plays: a review
作者
关键词
-
出版物
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 472, Issue 11, Pages 1535-1546
出版商
Springer Science and Business Media LLC
发表日期
2020-09-16
DOI
10.1007/s00424-020-02459-1
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress
- (2020) Mario Ost et al. EMBO REPORTS
- GDF15: A hormone conveying somatic distress to the brain
- (2020) Samuel M Lockhart et al. ENDOCRINE REVIEWS
- Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
- (2020) Jörg Wischhusen et al. Frontiers in Immunology
- GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
- (2019) Satish Patel et al. Cell Metabolism
- Elevated Serum Growth Differentiation Factor 15 Levels in Hyperthyroid Patients
- (2019) Jiejie Zhao et al. Frontiers in Endocrinology
- Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases
- (2019) Seung Joon Baek et al. PHARMACOLOGY & THERAPEUTICS
- Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion
- (2019) Wenchu Wang et al. ONCOGENE
- mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism
- (2019) Huibin Tang et al. AGING CELL
- Circulating levels of growth differentiation factor 15 and sex hormones in male patients with HBV-associated hepatocellular carcinoma
- (2019) Juanjuan Chen et al. BIOMEDICINE & PHARMACOTHERAPY
- GDF15 mediates the effects of metformin on body weight and energy balance
- (2019) Anthony P. Coll et al. NATURE
- Plasma proteomic signature of age in healthy humans
- (2018) Toshiko Tanaka et al. AGING CELL
- Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse
- (2018) Takashi Ito et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2
- (2018) Shan Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Human Aging and Longevity Are Characterized by High Levels of Mitokines
- (2018) Maria Conte et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- CRP Stimulates GDF15 Expression in Endothelial Cells through p53
- (2018) Yoonseo Kim et al. MEDIATORS OF INFLAMMATION
- Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond
- (2018) Shannon E. Mullican et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
- (2018) Marlena S. Fejzo et al. Nature Communications
- Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice
- (2018) Kook Hwan Kim et al. Scientific Reports
- Exercise increases circulating GDF15 in humans
- (2018) Maximilian Kleinert et al. Molecular Metabolism
- A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood
- (2018) Jiyang Jiang et al. Frontiers in Genetics
- GDF15 maturation requires proteolytic cleavage by PCSK3, 5 and 6
- (2018) Jing Jing Li et al. MOLECULAR AND CELLULAR BIOLOGY
- GDF15 deficiency promotes high fat diet-induced obesity in mice
- (2018) Thanhvien Tran et al. PLoS One
- GDF15 and Growth Control
- (2018) Paul J. Emmerson et al. Frontiers in Physiology
- GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation
- (2018) Yixin Zhang et al. Frontiers in Immunology
- Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity
- (2017) V W Tsai et al. INTERNATIONAL JOURNAL OF OBESITY
- Growth Differentiation Factor–15 and Risk of CKD Progression
- (2017) Viji Nair et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
- (2017) Jer-Yuan Hsu et al. NATURE
- GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
- (2017) Linda Yang et al. NATURE MEDICINE
- GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
- (2017) Shannon E Mullican et al. NATURE MEDICINE
- The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
- (2017) Paul J Emmerson et al. NATURE MEDICINE
- Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys
- (2017) Yumei Xiong et al. Science Translational Medicine
- CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer
- (2017) Mengjiao Han et al. Oncotarget
- Over-expression of growth differentiation factor 15 (GDF15) preventing cold ischemia reperfusion (I/R) injury in heart transplantation through Foxo3a signaling
- (2017) Yixin Zhang et al. Oncotarget
- An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
- (2017) Asako Sasahara et al. Oncotarget
- Elevated serum growth differentiation factor 15 levels are associated with thyroid nodules in type 2 diabetes aged over 60 years
- (2017) Hongmei Zhang et al. Oncotarget
- Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide
- (2017) Palida Abulizi et al. Scientific Reports
- GDF-15 enhances intracellular Ca2+ by increasing Cav1.3 expression in rat cerebellar granule neurons
- (2016) J.-M. Lu et al. BIOCHEMICAL JOURNAL
- GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF- RII heterodimer
- (2016) A. Artz et al. BLOOD
- Macrophage inhibitory cytokine-1/growth differentiation factor 15 as a marker of cognitive ageing and dementia
- (2016) Jiyang Jiang et al. CURRENT OPINION IN PSYCHIATRY
- Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders
- (2016) Yasunori Fujita et al. Geriatrics & Gerontology International
- Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
- (2016) Hyo Kyun Chung et al. JOURNAL OF CELL BIOLOGY
- Growth differentiation factor-15 and white matter hyperintensities in cognitive impairment and dementia
- (2016) Yuek Ling Chai et al. MEDICINE
- Growth/differentiation factor-15 deficiency compromises dopaminergic neuron survival and microglial response in the 6-hydroxydopamine mouse model of Parkinson's disease
- (2016) Venissa Machado et al. NEUROBIOLOGY OF DISEASE
- A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases
- (2016) Ryan L. Davis et al. NEUROLOGY
- GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and Lewy Body Dementia
- (2016) Walter Maetzler et al. PLoS One
- TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
- (2016) Masato Morikawa et al. Cold Spring Harbor Perspectives in Biology
- Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels
- (2016) Dong-Dong Liu et al. Scientific Reports
- Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting
- (2016) Zhize Yuan et al. Scientific Reports
- The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies
- (2015) Betül Ünal et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
- NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway
- (2015) K-W Min et al. ONCOGENE
- Mutant GDF15 presents a poor prognostic outcome for patients with oral squamous cell carcinoma
- (2015) Jie Ma et al. Oncotarget
- Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation, invasion, and tumorigenesis in bladder carcinoma cells
- (2015) Ke-Hung Tsui et al. Scientific Reports
- MAP3K11/GDF15 axis is a critical driver of cancer cachexia
- (2015) Lorena Lerner et al. Journal of Cachexia Sarcopenia and Muscle
- Growth Differentiation Factor 15 Expression in Astrocytes After Excitotoxic Lesion in the Mouse Hippocampus
- (2015) Min-Hee Yi et al. Experimental Neurobiology
- Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI
- (2015) Vicky Wang-Wei Tsai et al. PLoS One
- NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
- (2014) K Chrysovergis et al. INTERNATIONAL JOURNAL OF OBESITY
- Growth Differentiation Factor (GDF)-15 Blocks Norepinephrine-induced Myocardial Hypertrophy via a Novel Pathway Involving Inhibition of Epidermal Growth Factor Receptor Transactivation
- (2014) Xin-ye Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Opposing Effects of PI3K/Akt and Smad-Dependent Signaling Pathways in NAG-1-Induced Glioblastoma Cell Apoptosis
- (2014) Zhiguo Zhang et al. PLoS One
- Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate
- (2014) James R. Lambert et al. PROSTATE
- The regulation of TGF-β/SMAD signaling by protein deubiquitination
- (2014) Juan Zhang et al. Protein & Cell
- SMAD regulatory networks construct a balanced immune system
- (2013) Nidhi Malhotra et al. IMMUNOLOGY
- TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator
- (2013) Vicky Wang-Wei Tsai et al. PLoS One
- Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer
- (2013) Long Zhang et al. TRENDS IN BIOCHEMICAL SCIENCES
- The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer
- (2012) Xingya Wang et al. BIOCHEMICAL PHARMACOLOGY
- Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?
- (2012) D. A. Brown et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Promiscuity and specificity in BMP receptor activation
- (2012) Thomas D. Mueller et al. FEBS LETTERS
- TGFβ signalling in context
- (2012) Joan Massagué NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets
- (2012) Laurence Macia et al. PLoS One
- The TGFbeta Superfamily Signaling Pathway
- (2012) Alexander Weiss et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Non-Smad signaling pathways
- (2011) Yabing Mu et al. CELL AND TISSUE RESEARCH
- TGF-β/TGF-β receptor system and its role in physiological and pathological conditions
- (2011) Juan F. Santibañez et al. CLINICAL SCIENCE
- Wild-Type p53 Attenuates Cancer Cell Motility by Inducing Growth Differentiation Factor-15 Expression
- (2011) Jung-Chien Cheng et al. ENDOCRINOLOGY
- Latent TGF-β structure and activation
- (2011) Minlong Shi et al. NATURE
- GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
- (2011) Tibor Kempf et al. NATURE MEDICINE
- Role of TGF-β signaling in inherited and acquired myopathies
- (2011) Tyesha N Burks et al. Skeletal Muscle
- GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas
- (2010) P. Roth et al. CLINICAL CANCER RESEARCH
- Growth differentiation factor 15 in erythroid health and disease
- (2010) Toshihiko Tanno et al. CURRENT OPINION IN HEMATOLOGY
- Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer
- (2010) Murielle Mimeault et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The TGF-β Superfamily Cytokine MIC-1/GDF15: Secretory Mechanisms Facilitate Creation of Latent Stromal Stores
- (2010) Asne R. Bauskin et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15
- (2009) J. Strelau et al. JOURNAL OF NEUROSCIENCE
- Role of transforming growth factor-β superfamily signaling pathways in human disease
- (2008) Kelly J. Gordon et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- TGFβ in Cancer
- (2008) Joan Massagué CELL
- Brain Area-Specific Effect of TGF-β Signaling on Wnt-Dependent Neural Stem Cell Expansion
- (2008) Sven Falk et al. Cell Stem Cell
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