TGFβ signalling in context

Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling

(2012) Ki-Sook Park et al.   DEVELOPMENTAL BIOLOGY

Phosphatases in SMAD regulation

(2012) David L. Bruce et al.   FEBS LETTERS

Regulation of Transcription Factor Twist Expression by the DNA Architectural Protein High Mobility Group A2 during Epithelial-to-Mesenchymal Transition

(2012) E-Jean Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: Role of fibrillins and fibronectin

(2012) Lior Zilberberg et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TGF-β-Dependent Active Demethylation and Expression of the p15ink4b Tumor Suppressor Are Impaired by the ZNF217/CoREST Complex

(2012) Gobi Thillainadesan et al.   MOLECULAR CELL

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

(2012) Long Zhang et al.   NATURE CELL BIOLOGY

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

(2012) Pieter J A Eichhorn et al.   NATURE MEDICINE

Premature Senescence and Increased TGFβ Signaling in the Absence of Tgif1

(2012) Brad J. Zerlanko et al.   PLoS One

Differential Diffusivity of Nodal and Lefty Underlies a Reaction-Diffusion Patterning System

(2012) P. Muller et al.   SCIENCE

USP11 augments TGF  signalling by deubiquitylating ALK5

(2012) M. A. Al-Salihi et al.   Open Biology

Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway

(2012) Kenichiro Taniguchi et al.   PLoS Genetics

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

A Poised Chromatin Platform for TGF-β Access to Master Regulators

(2011) Qiaoran Xi et al.   CELL

Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration

(2011) Eirini Trompouki et al.   CELL

Chromatin Connections to Pluripotency and Cellular Reprogramming

(2011) Stuart H. Orkin et al.   CELL

Control of the Embryonic Stem Cell State

(2011) Richard A. Young   CELL

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

Systems control of BMP morphogen flow in vertebrate embryos

(2011) Jean-Louis Plouhinec et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

HEB and E2A function as SMAD/FOXH1 cofactors

(2011) S.-J. Yoon et al.   GENES & DEVELOPMENT

A comprehensive review of reported heritable noggin-associated syndromes and proposed clinical utility of one broadly inclusive diagnostic term: NOG-related-symphalangism spectrum disorder (NOG-SSD)

(2011) Tommy A. Potti et al.   HUMAN MUTATION

Recruitment of TIF1γ to Chromatin via Its PHD Finger-Bromodomain Activates Its Ubiquitin Ligase and Transcriptional Repressor Activities

(2011) Eleonora Agricola et al.   MOLECULAR CELL

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Lessons on the pathogenesis of aneurysm from heritable conditions

(2011) Mark E. Lindsay et al.   NATURE

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

(2011) Oliver G McDonald et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

(2011) Masato Morikawa et al.   NUCLEIC ACIDS RESEARCH

Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development

(2011) M. Paulsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

Coordinating developmental signaling: novel roles for the Hippo pathway

(2011) Xaralabos Varelas et al.   TRENDS IN CELL BIOLOGY

Overlapping spectra ofSMAD4mutations in juvenile polyposis (JP) and JP-HHT syndrome

(2010) Carol Gallione et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

HER2 Silences Tumor Suppression in Breast Cancer Cells by Switching Expression of C/EBP  Isoforms

(2010) A. Arnal-Estape et al.   CANCER RESEARCH

TGF- -RI Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases

(2010) K. S. Mohammad et al.   CANCER RESEARCH

TGF-β Signaling Specifies Axons during Brain Development

(2010) Jason J. Yi et al.   CELL

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

Extracellular regulation of BMP signaling

(2010) Lise Zakin et al.   CURRENT BIOLOGY

Negative control of Smad activity by ectodermin/Tif1  patterns the mammalian embryo

(2010) L. Morsut et al.   DEVELOPMENT

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

Requirement of TCF7L2 for TGF-β-dependent Transcriptional Activation of the TMEPAI Gene

(2010) Naoko Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Nucleoporin Requirement for Smad Nuclear Translocation

(2010) X. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

PARP-1 Attenuates Smad-Mediated Transcription

(2010) Peter Lönn et al.   MOLECULAR CELL

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors

(2010) Nithya BabuRajendran et al.   NUCLEIC ACIDS RESEARCH

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

(2009) Lukasz Huminiecki et al.   BMC EVOLUTIONARY BIOLOGY

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

(2009) Silvia Peñuelas et al.   CANCER CELL

Promoter-wide analysis of Smad4 binding sites in human epithelial cells

(2009) Daizo Koinuma et al.   CANCER SCIENCE

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

(2009) Justin K. Ichida et al.   Cell Stem Cell

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc

(2009) Nimet Maherali et al.   CURRENT BIOLOGY

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

(2009) Carl-Henrik Heldin et al.   CURRENT OPINION IN CELL BIOLOGY

The regulation of TGF  signal transduction

(2009) A. Moustakas et al.   DEVELOPMENT

Nuclear Export of Smad2 and Smad3 by RanBP3 Facilitates Termination of TGF-β Signaling

(2009) Fangyan Dai et al.   DEVELOPMENTAL CELL

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination

(2009) T. Fei et al.   GENOME RESEARCH

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

A role for the TGF -Par6 polarity pathway in breast cancer progression

(2009) A. M. Viloria-Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nodal Morphogens

(2009) A. F. Schier   Cold Spring Harbor Perspectives in Biology

Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas

(2009) David F. Vincent et al.   PLoS Genetics

TGF-β: A Master of All T Cell Trades

(2008) Ming O. Li et al.   CELL

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

(2008) Xi Chen et al.   CELL

Nucleocytoplasmic shuttling of Smad proteins

(2008) Caroline S Hill   CELL RESEARCH

The Decapentaplegic morphogen gradient: a precise definition

(2008) Anna Kicheva et al.   CURRENT OPINION IN CELL BIOLOGY

HMGA2 and Smads Co-regulate SNAIL1 Expression during Induction of Epithelial-to-Mesenchymal Transition

(2008) Sylvie Thuault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin Immunoprecipitation on Microarray Analysis of Smad2/3 Binding Sites Reveals Roles of ETS1 and TFAP2A in Transforming Growth Factor   Signaling

(2008) D. Koinuma et al.   MOLECULAR AND CELLULAR BIOLOGY

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

(2008) Agnidipta Ghosh et al.   MOLECULAR CELL

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE