Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

(2016) Xingya Wang et al.   Aging-US

Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15

(2015) V W W Tsai et al.   INTERNATIONAL JOURNAL OF OBESITY

GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective

(2015) Ramu Adela et al.   Journal of Diabetes Research

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

(2014) K Chrysovergis et al.   INTERNATIONAL JOURNAL OF OBESITY

The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract

(2014) Vicky Wang-Wei Tsai et al.   PLoS One

Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity

(2013) Xingya Wang et al.   Obesity

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

(2013) Vicky Wang-Wei Tsai et al.   PLoS One

Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/− mice from the development of atherosclerosis

(2012) Heiko Johnen et al.   CARDIOVASCULAR PATHOLOGY

Adiponectin Corrects High-Fat Diet-Induced Disturbances in Muscle Metabolomic Profile and Whole-Body Glucose Homeostasis

(2012) Y. Liu et al.   DIABETES

Growth-Differentiation Factor 15 Predicts Worsening of Albuminuria in Patients With Type 2 Diabetes

(2012) M. E. Hellemons et al.   DIABETES CARE

Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial

(2012) Tibor Kempf et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

(2012) Laurence Macia et al.   PLoS One

Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15

(2012) Vicky W. W. Tsai et al.   Journal of Cachexia Sarcopenia and Muscle

The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

(2011) Samuel N. Breit et al.   GROWTH FACTORS

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease

(2011) S. N. Breit et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality

(2010) Fredrik E. Wiklund et al.   AGING CELL

Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis

(2010) N. Luo et al.   DIABETES

Plasma Growth Differentiation Factor-15 Independently Predicts All-Cause and Cardiovascular Mortality As Well As Deterioration of Kidney Function in Type 1 Diabetic Patients With Nephropathy

(2010) M. Lajer et al.   DIABETES CARE

Macrophage inhibitory cytokine-1 is increased in individuals before type 2 diabetes diagnosis but is not an independent predictor of type 2 diabetes: the Whitehall II study

(2010) Maren Carstensen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Macrophage Inhibitory Cytokine 1: A New Prognostic Marker in Prostate Cancer

(2009) D. A. Brown et al.   CLINICAL CANCER RESEARCH

Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet

(2009) Ivana Dostálová et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Growth-Differentiation Factor-15 in Heart Failure

(2009) Tibor Kempf et al.   Heart Failure Clinics

Effect of Peroxisome Proliferator–activated Receptor-α Ligands in the Interaction Between Adipocytes and Macrophages in Obese Adipose Tissue

(2008) Takuya Toyoda et al.   Obesity