MAP3K11/GDF15 axis is a critical driver of cancer cachexia

Targeting molecular addictions in cancer

(2014) I Vivanco   BRITISH JOURNAL OF CANCER

The energy balance in cancer cachexia revisited

(2014) Judith de Vos-Geelen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer

(2014) Moisés Blanco-Calvo et al.   Future Oncology

Growth-differentiation factor 15 for long-term prognostication in patients with non-ST-elevation acute coronary syndrome: An Invasive versus Conservative Treatment in Unstable coronary Syndromes (ICTUS) substudy

(2014) Peter Damman et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pharmacological Inhibition of Myostatin and Changes in Lean Body Mass and Lower Extremity Muscle Size in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer

(2014) Desmond Padhi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Abridged Patient-Generated Subjective Global Assessment Is a Useful Tool for Early Detection and Characterization of Cancer Cachexia

(2014) Antonio L. Vigano et al.   Journal of the Academy of Nutrition and Dietetics

Inflammation Based Regulation of Cancer Cachexia

(2014) Jill K. Onesti et al.   Biomed Research International

Cachexia: a problem of energetic inefficiency

(2014) Josep M. Argilés et al.   Journal of Cachexia Sarcopenia and Muscle

Biomarkers of Cardiovascular Stress and Incident Chronic Kidney Disease

(2013) J. E. Ho et al.   CLINICAL CHEMISTRY

The Role of Inflammatory Pathways in Cancer-Associated Cachexia and Radiation Resistance

(2013) A. Laine et al.   MOLECULAR CANCER RESEARCH

GDF-15 for Prognostication of Cardiovascular and Cancer Morbidity and Mortality in Men

(2013) Lars Wallentin et al.   PLoS One

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

(2012) Kenneth C.H. Fearon et al.   Cell Metabolism

P-selectin genotype is associated with the development of cancer cachexia

(2012) Benjamin H. L. Tan et al.   EMBO Molecular Medicine

Resting Energy Expenditure and Energetic Cost of Feeding Are Augmented after Roux-en-Y Gastric Bypass in Obese Mice

(2012) Eirini Nestoridi et al.   ENDOCRINOLOGY

Understanding the mechanisms and treatment options in cancer cachexia

(2012) Kenneth Fearon et al.   Nature Reviews Clinical Oncology

Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15

(2012) Vicky W. W. Tsai et al.   Journal of Cachexia Sarcopenia and Muscle

Biologic and Clinical Activity of Tivozanib (AV-951, KRN-951), a Selective Inhibitor of VEGF Receptor-1, -2, and -3 Tyrosine Kinases, in a 4-Week-On, 2-Week-Off Schedule in Patients with Advanced Solid Tumors

(2011) F. A. L. M. Eskens et al.   CLINICAL CANCER RESEARCH

Elevated Plasma Growth Differentiation Factor-15 Correlates with Lymph Node Metastases and Poor Survival in Endometrial Cancer

(2011) A. C. Staff et al.   CLINICAL CANCER RESEARCH

Association of Growth Differentiation Factor-15 with Coronary Atherosclerosis and Mortality in a Young, Multiethnic Population: Observations from the Dallas Heart Study

(2011) A. Rohatgi et al.   CLINICAL CHEMISTRY

Is IL-6 the best pro-inflammatory biomarker of clinical outcomes of cancer cachexia?

(2011) Celena Scheede-Bergdahl et al.   CLINICAL NUTRITION

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease

(2011) S. N. Breit et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Cancer Cachexia: Mechanisms and Clinical Implications

(2011) Claire L. Donohoe et al.   Gastroenterology Research and Practice

Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance

(2011) Sílvia Busquets et al.   Journal of Cachexia Sarcopenia and Muscle

Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality

(2010) Fredrik E. Wiklund et al.   AGING CELL

Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer

(2010) R J E Skipworth et al.   BRITISH JOURNAL OF CANCER

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

(2010) E. Buck et al.   MOLECULAR CANCER THERAPEUTICS

Mixed Lineage Kinase-3/JNK1 Axis Promotes Migration of Human Gastric Cancer Cells following Gastrin Stimulation

(2010) Prajna Mishra et al.   MOLECULAR ENDOCRINOLOGY

Cancer as a metabolic disease

(2010) Thomas N Seyfried et al.   Nutrition & Metabolism

Cachexia as a major underestimated and unmet medical need: facts and numbers

(2010) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

(2009) Margaret E. Benny Klimek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Roux-en-Y Gastric Bypass Enhances Energy Expenditure and Extends Lifespan in Diet-induced Obese Rats

(2009) Nicholas Stylopoulos et al.   Obesity

Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: A MLK-3-MKK7-dependent mechanism

(2007) Harish Muniyappa et al.   CELLULAR SIGNALLING