Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS

(2019) Vicky Wang-Wei Tsai et al.   INTERNATIONAL JOURNAL OF OBESITY

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

(2019) Saara Forsström et al.   Cell Metabolism

Metabolic implications of organelle–mitochondria communication

(2019) Isabel Gordaliza‐Alaguero et al.   EMBO REPORTS

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

(2018) Elizabeth F. Sutton et al.   Cell Metabolism

Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance

(2018) Shylesh Bhaskaran et al.   EMBO REPORTS

CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis

(2018) Christina Becker et al.   EMBO REPORTS

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Human Aging and Longevity Are Characterized by High Levels of Mitokines

(2018) Maria Conte et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

(2018) Marlena S. Fejzo et al.   Nature Communications

Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling

(2018) Verena Coleman et al.   Scientific Reports

Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

(2018) Amandine Chaix et al.   Cell Metabolism

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Mitochondrial diseases: the contribution of organelle stress responses to pathology

(2017) Anu Suomalainen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity

(2017) Ryan M. Morrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway

(2017) Samuel N. Breit et al.   TRENDS IN MOLECULAR MEDICINE

Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers

(2017) Hélène Lemieux et al.   Scientific Reports

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

(2016) Joni Nikkanen et al.   Cell Metabolism

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

(2016) Jenni M. Lehtonen et al.   NEUROLOGY

A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases

(2016) Ryan L. Davis et al.   NEUROLOGY

Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle

(2016) Bolormaa Vandanmagsar et al.   Cell Reports

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

(2016) Mario Ost et al.   Molecular Metabolism

GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction

(2016) Raquel Montero et al.   PLoS One

A stringent validation of mouse adipose tissue identity markers

(2015) Jasper M. A. de Jong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux

(2015) Mario Ost et al.   FASEB JOURNAL

High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice

(2015) Christopher E. Wall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

(2015) Lucie Geurts et al.   Nature Communications

MAP3K11/GDF15 axis is a critical driver of cancer cachexia

(2015) Lorena Lerner et al.   Journal of Cachexia Sarcopenia and Muscle

Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients

(2015) Lorena Lerner et al.   Journal of Cachexia Sarcopenia and Muscle

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

(2015) Vicky Wang-Wei Tsai et al.   PLoS One

Metabolic remodeling of white adipose tissue in obesity

(2014) Timothy D. Cummins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

(2014) Susana Kalko et al.   BMC GENOMICS

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

(2014) K Chrysovergis et al.   INTERNATIONAL JOURNAL OF OBESITY

Activation of AMPKα2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity

(2014) Mario Ost et al.   PLoS One

The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract

(2014) Vicky Wang-Wei Tsai et al.   PLoS One

Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

(2013) S. Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

(2013) Vicky Wang-Wei Tsai et al.   PLoS One

Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?

(2013) Jill Corre et al.   Stem Cells Translational Medicine

Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes

(2012) Maria H. Holmström et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

(2012) Laurence Macia et al.   PLoS One

Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15

(2012) Vicky W. W. Tsai et al.   Journal of Cachexia Sarcopenia and Muscle

Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting

(2012) John J McCarthy et al.   Skeletal Muscle

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

(2011) Samuel N. Breit et al.   GROWTH FACTORS

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

The TGF-β Superfamily Cytokine MIC-1/GDF15: Secretory Mechanisms Facilitate Creation of Latent Stromal Stores

(2010) Asne R. Bauskin et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production

(2009) Susanne Keipert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo

(2008) Susanne Neschen et al.   PHYSIOLOGICAL GENOMICS

Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1

(2007) Yvonne Katterle et al.   PHYSIOLOGICAL GENOMICS