Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
出版年份 2019 全文链接
标题
Chromatin‐bound
cGAS
is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
作者
关键词
-
出版物
EMBO JOURNAL
Volume -, Issue -, Pages -
出版商
EMBO
发表日期
2019-09-23
DOI
10.15252/embj.2019102718
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
- (2019) Matteo Gentili et al. Cell Reports
- Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
- (2019) Katherine C. Barnett et al. CELL
- The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?
- (2019) Nelson O. Gekara et al. Science Signaling
- The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
- (2019) Christian Zierhut et al. CELL
- NGL viewer: web-based molecular graphics for large complexes
- (2018) Alexander S Rose et al. BIOINFORMATICS
- Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance
- (2018) Wen Zhou et al. CELL
- A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion
- (2018) Pengyan Xia et al. IMMUNITY
- Chromosomal instability drives metastasis through a cytosolic DNA response
- (2018) Samuel F. Bakhoum et al. NATURE
- DNA-induced liquid phase condensation of cGAS activates innate immune signaling
- (2018) Mingjian Du et al. SCIENCE
- Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
- (2018) Haipeng Liu et al. NATURE
- The allosteric activation of cGAS underpins its dynamic signaling landscape
- (2018) Richard M Hooy et al. eLife
- A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1
- (2017) Erkin Erdal et al. GENES & DEVELOPMENT
- Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy
- (2017) Kareen Bartsch et al. HUMAN MOLECULAR GENETICS
- DNA damage-induced immune response: Micronuclei provide key platform
- (2017) Nelson O. Gekara JOURNAL OF CELL BIOLOGY
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Mitotic progression following DNA damage enables pattern recognition within micronuclei
- (2017) Shane M. Harding et al. NATURE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders
- (2017) Liudmila Andreeva et al. NATURE
- cGAS is essential for the antitumor effect of immune checkpoint blockade
- (2017) Hua Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity
- (2016) Saskia F. Erttmann et al. IMMUNITY
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
- (2016) M. Raab et al. SCIENCE
- Repair Pathway Choices and Consequences at the Double-Strand Break
- (2016) Raphael Ceccaldi et al. TRENDS IN CELL BIOLOGY
- DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
- (2015) Anetta Härtlova et al. IMMUNITY
- Mitochondrial DNA stress primes the antiviral innate immune response
- (2015) A. Phillip West et al. NATURE
- Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis
- (2015) Weixing Zhao et al. NUCLEIC ACIDS RESEARCH
- STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
- (2014) Seng-Ryong Woo et al. IMMUNITY
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
- (2014) Liufu Deng et al. IMMUNITY
- The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes
- (2014) Qi Zhao et al. Nature Communications
- Inflammation-driven carcinogenesis is mediated through STING
- (2014) Jeonghyun Ahn et al. Nature Communications
- Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1
- (2014) Shinichi Machida et al. Scientific Reports
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
- (2013) Xin Li et al. IMMUNITY
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
- (2013) Xu Zhang et al. MOLECULAR CELL
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- (2013) Andrea Ablasser et al. NATURE
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
- (2013) John W. Schoggins et al. NATURE
- Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
- (2013) D. Gao et al. SCIENCE
- Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
- (2013) Philip J. Kranzusch et al. Cell Reports
- The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
- (2013) Elie J. Diner et al. Cell Reports
- Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
- (2012) J. Ross Chapman et al. MOLECULAR CELL
- DNA breaks and chromosome pulverization from errors in mitosis
- (2012) Karen Crasta et al. NATURE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- Mitotic catastrophe: a mechanism for avoiding genomic instability
- (2011) Ilio Vitale et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
- (2010) Niraj M. Shanbhag et al. CELL
- TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides
- (2010) John-Demian Sauer et al. INFECTION AND IMMUNITY
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
- Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
- (2008) Nicole Bennardo et al. PLoS Genetics
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