Article
Biochemistry & Molecular Biology
Jie Zeng, Si-Li He, Li-Jie Li, Chen Wang
Summary: The study found that Hsp90 expression is up-regulated in HPV16(+) cervical cancer tissues and cells, and knockdown of Hsp90 inhibited the proliferation and migration of cervical cancer cells. PD-L1 expression in cervical cancer tissues was positively correlated with Hsp90 expression, and Hsp90 regulated PD-L1 expression via the HER2/PI3K/AKT signaling pathway. The results suggest that Hsp90 knockdown has therapeutic potential in treating HPV16(+) cervical cancers.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Siddhi Omkar, Tasaduq H. Wani, Bo Zheng, Megan M. Mitchem, Andrew W. Truman
Summary: This study shows that APE2 and Apn2 proteins depend on the chaperone system in yeast and mammalian cells, and suggests that inhibiting chaperones may be a potential anticancer therapy targeting APE2-mediated processes.
Article
Biochemistry & Molecular Biology
Mahamat Babagana, Lorin R. Brown, Hannah Z. Slabodkin, Julia V. Kichina, Eugene S. Kandel
Summary: Hyperactivity of AKT in cancer cells leads to increased sensitivity to proteotoxic stress, manifested by heightened response to heat shock and greater dependence on XBP1 for growth. This stress-induced vulnerability can be exploited for therapeutic targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Rachel E. Lackie, Aline S. de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madrer, Nadun C. Karunatilleke, Benjamin S. Rutledge, Stephanie Tullo, Anne Brickenden, Matthew E. R. Maitland, David Greenberg, Daniel Gallino, Wen Luo, Anoosha Attaran, Irina Shlaifer, Esther Del Cid Pellitero, Caroline Schild-Poulter, Thomas M. Durcan, Edward A. Fon, Martin Duennwald, Flavio H. Beraldo, M. Mallar Chakravarty, Timothy J. Bussey, Lisa M. Saksida, Hermona Soreq, Wing-Yiu Choy, Vania F. Prado, Marco A. M. Prado
Summary: The co-chaperone STI1 interacts with alpha-synuclein and plays a role in its misfolding and aggregation. Decreased STI1 function can reduce protein inclusion formation and improve motor and cognitive deficits caused by alpha-synuclein overexpression.
ACTA NEUROPATHOLOGICA
(2022)
Article
Medicine, Research & Experimental
Weichen Wang, Qing Yin, Shanshan Guo, Jun Wang
Summary: In liver cancer, high NEIL3 expression is associated with tumor grade and survival time. NEIL3 is abundantly expressed in liver cancer cell lines, and its knockdown impairs cell functions, causes cell cycle arrest at G2 phase, and increases apoptotic rate. Additionally, NEIL3 regulates the PI3K/Akt/mTOR signaling pathway in liver cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yan Cheng, Fumou Sun, Krista Thornton, Xuefang Jing, Jing Dong, Grant Yun, Michael Pisano, Fenghuang Zhan, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Parameswaran Hari, Siegfried Janz
Summary: FOXM1 plays a crucial role in myeloma metabolism by regulating glycolysis and oxidative phosphorylation pathways. Inhibiting FOXM1 can effectively suppress myeloma growth, offering potential new approaches for therapy and prevention.
Article
Environmental Sciences
Chien-Chang Kao, Yi-Ching Cheng, Ming-Hsin Yang, Tai-Lung Cha, Guang-Huan Sun, Chi-Tang Ho, Ying-Chao Lin, Hao-Kuang Wang, Sheng-Tang Wu, Tzong-Der Way
Summary: Curcuminoids have shown inhibitory effects on HER2-overexpressing bladder cancer cells, and can be used in combination with chemotherapeutic agents to exhibit additive activity, indicating their potential as a new candidate for anti-tumor drug development.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Taylor Arhar, Arielle Shkedi, Cory M. Nadel, Jason E. Gestwicki
Summary: Molecular chaperones, despite their diverse sequences, sizes, and shapes, all bind to unfolded proteins to assist in their folding. Recent advancements in NMR spectroscopy have allowed for detailed studies on how different chaperones interact with client proteins. These studies have revealed both similarities and differences in how chaperones release clients and how ATP cycling affects the folding process.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Song-Hua Hu, Xia-Di He, Ji Nie, Jun-Li Hou, Jiang Wu, Xiao-Yan Liu, Yun Wei, Hui-Ru Tang, Wen-Xing Sun, Shu-Xian Zhou, Yi-Yuan Yuan, Yan-Peng An, Guo-Quan Yan, Yan Lin, Peng-Cheng Lin, Jean J. Zhao, Ming-Liang Ye, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao
Summary: This study reveals that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) regulate cell signaling pathways by modifying specific proteins, and identifies the underlying mechanisms of their effects on the PI3K-AKT signaling pathway.
Article
Oncology
Ji Song, Yanshi Li, Tao Lu, Min Pan, Zhihai Wang, Chuan Liu, Yang Liao, Guohua Hu
Summary: This study investigated the expression of SPHK2 and miR-19a-3p in patients with HSCC and their impact on HSCC invasion and metastasis. It was found that elevated levels of SPHK2 were associated with lymph node metastasis and poor prognosis. Furthermore, miR-19a-3p was found to regulate tumor proliferation and invasion through the PI3K/AKT axis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jinming Zhang, Wenshan Zhong, Yuanyuan Liu, Weimou Chen, Ye Lu, Zhaojin Zeng, Yujie Qiao, Haohua Huang, Xuan Wan, Wei Li, Xiaojing Meng, Fei Zou, Shaoxi Cai, Hangming Dong
Summary: The interaction between extracellular HSP90 alpha and endoplasmic reticulum stress plays a crucial role in pulmonary fibrosis, promoting lung fibroblast differentiation by activating ER stress. Inhibiting ER stress can effectively block the effects of eHSP90 alpha. The induction of ER stress by eHSP90 alpha in fibroblasts occurs through the PI3K/AKT signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Rui Zhang, Ye Hua Wang, Xin Shi, Jiang Ji, Fu Qin Zhan, Hong Leng
Summary: In this study, it was found that suppressed sortilin expression can inhibit keratinocyte proliferation in HaCaT cells by inactivating the PI3K/AKT signaling pathway, providing a new target for the therapy of psoriasis. Additionally, sortilin silencing was shown to alleviate the characteristic changes associated with psoriasis-like skin lesions.
Article
Cell Biology
Jiangyan Chen, Lin Huang, Jin Quan, Debing Xiang
Summary: Abnormal upregulation of TRIM14 in melanoma may promote malignant transformation, while silencing of TRIM14 may inhibit proliferation and invasion of melanoma cells.
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
S. Mark Roe, Zsolt Toeroek, Andrew McGown, Ibolya Horvath, John Spencer, Tamas Pazmany, Laszlo Vigh, Chrisostomos Prodromou
Summary: Functional changes in chaperone systems have a role in the decline of cognition and contribute to neurological diseases like Alzheimer's disease (AD). Amyloid-β (Aβ) plaque formation leads to tau hyperphosphorylation, resulting in neurofibrillary tangle formation and neurotoxicity. FKBP51, FKBP52, and PP5 are co-chaperones that can influence tau phosphorylation. LA1011 can disrupt the binding of FKBP51 to rebalance Hsp90-FKBP51 machinery and provide a favorable prognosis for AD.
Article
Oncology
Susann Weissbach, Sofia Catalina Heredia-Guerrero, Stefanie Barnsteiner, Lukas Grosshans, Jochen Bodem, Hanna Starz, Christian Langer, Silke Appenzeller, Stefan Knop, Torsten Steinbrunn, Simone Rost, Hermann Einsele, Ralf Christian Bargou, Andreas Rosenwald, Thorsten Stuehmer, Ellen Leich
Article
Hematology
Antonio G. Solimando, Matteo C. Da Via, Patrizia Leone, Paola Borrelli, Giorgio A. Croci, Paula Tabares, Andreas Brandl, Giuseppe Di Lernia, Francesco P. Bianchi, Silvio Tafuri, Torsten Steinbrunn, Alessandra Balduini, Assunta Melaccio, Simona De Summa, Antonella Argentiero, Hilka Rauert-Wunderlich, Maria A. Frassanito, Paolo Ditonno, Erik Henke, Wolfram Klapper, Roberto Ria, Carolina Terragna, Leo Rasche, Andreas Rosenwald, K. Martin Kortum, Michele Cavo, Domenico Ribatti, Vito Racanelli, Hermann Einsele, Angelo Vacca, Andreas Beilhack
Summary: The interaction between malignant multiple myeloma (MM) plasma cells and the microenvironment, particularly bone marrow MM endothelial cells expressing junctional adhesion molecule-A (JAM-A), plays a crucial role in regulating MM progression. Elevated expression of JAM-A in MM endothelial cells is associated with poor clinical outcomes and advanced disease. Blocking JAM-A has shown to restrict angiogenesis and impede MM progression, suggesting it as a potential therapeutic target for halting neo-angiogenesis in MM.
Article
Oncology
Torsten Steinbrunn, Stefan Knop, Hermann Einsele
Letter
Oncology
Ellen Leich, Martin Schreder, Jordan Pischimarov, Thorsten Stuhmer, Torsten Steinbrunn, Martina Rudelius, Daniela Bruennert, Manik Chatterjee, Christian Langer, Sarah Keppler, Sofia Catalina Heredia-Guerrero, Hermann Einsele, Stefan Knop, Ralf Christian Bargou, Andreas Rosenwald
BLOOD CANCER JOURNAL
(2021)
Article
Oncology
Gunhild Mechtersheimer, Mindaugas Andrulis, Klaus-Wolfgang Delank, Anna-Lena Volckmar, Lei Zhang, Moritz von Winterfeld, Albrecht Stenzinger, Cristina Antonescu
Summary: Biphenotypic sinonasal sarcoma (BSNS) is a rare low-grade spindle cell sarcoma characterized by dual myogenic and neural differentiation and recurrent gene fusions. A new RREB1-MKL2 fusion gene insertion was identified in a BSNS lesion, adding to the known genetic events associated with this tumor type.
GENES CHROMOSOMES & CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sabrina Kraus, Alexander Dierks, Leo Rasche, Olivia Kertels, Malte Kircher, Andreas Schirbel, Josip Zovko, Torsten Steinbrunn, Raoul Tibes, Hans-Jurgen Wester, Andreas K. Buck, Hermann Einsele, K. Martin Kortum, Andreas Rosenwald, Constantin Lapa
Summary: This study investigated the feasibility of CXCR4-directed imaging with Ga-68-pentixafor PET/CT in MPNs. The results showed that this method can noninvasively detect and quantify the extent of disease involvement in MPNs, and the dynamic changes in CXCR4 expression corresponded with treatment response.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Meeting Abstract
Hematology
Pooja Shah, Thorsten Stuehmer, Daniela Bruennert, Umair Munawar, Ellen Leich, Sabrina Kraus, Michael Hudecek, Manik Chatterjee, Andreas Schlosser, Ralf C. Bargou, Hermann Einsele, Friederike Berberich-Siebelt, Torsten Steinbrunn
Review
Oncology
Antonio Giovanni Solimando, Matteo Claudio Da Via, Niccolo Bolli, Torsten Steinbrunn
Summary: This article summarizes the interaction between multiple myeloma and the bone marrow microenvironment, and provides new treatment approaches for multiple myeloma. The study also reveals the role of tumor-stromal cells in immune microenvironment regulation and how to improve therapeutic outcomes.
Meeting Abstract
Oncology
P. Shah, T. Stuehmer, L. Haertle, D. Bruennert, U. Munawar, E. Leich, S. Kraus, M. Hudecek, M. Chatterjee, A. Schlosser, K. M. Kortuem, R. C. Bargou, H. Einsele, F. Berberich-Siebelt, T. Steinbrunn
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Meeting Abstract
Oncology
P. Shah, T. Stuehmer, D. Bruennert, U. Munawar, M. Chatterjee, R. C. Bargou, H. Einsele, F. Berberich-Siebelt, T. Steinbrunn
ONCOLOGY RESEARCH AND TREATMENT
(2021)
Article
Medicine, General & Internal
Ieva Dimiene, Kristina Bieksiene, Jurgita Zaveckiene, Mindaugas Andrulis, Daiva-Elzbieta Optazaite, Neringa Vaguliene, Marius Zemaitis, Skaidrius Miliauskas
Summary: Diffuse pulmonary lymphangiomatosis (DPL) is an exceptionally rare benign disease that mainly occurs in children and young adults. Due to its rarity, little guidance on diagnosis and treatment is available, posing a challenge for clinicians working with patients with DPL.
MEDICINA-LITHUANIA
(2021)
Meeting Abstract
Oncology
Pooja Shah, Thorsten Stuehmer, Daniela Bruennert, Umair Munawar, Ellen Leich, Sabrina Kraus, Manik Chatterjee, Andreas Schlosser, Ralf C. Bargou, Hermann Einsele, Friederike Berberich-Siebelt, Torsten Steinbrunn
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2021)
Meeting Abstract
Oncology
Antonio Solimando, Matteo Da Via, Giorgio Croci, Paola Borrelli, Paula Tabares, Andreas Brandl, Umair Munawar, Torsten Steinbrunn, Alessandra Balduini, Hilka Rauert-Wunderlich, Hannah Manz, Paolo Ditonno, Roberto Ria, Carolina Terragna, Nora Trinks, Ulrich Terpitz, Leo Rasche, Andreas Rosenwald, Martin Kortuem, Michele Cavo, Antonino Neri, Niccolo Bolli, Hermann Einsele, Angelo Vacca, Andreas Beilhack
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2021)
Review
Rheumatology
Torsten Steinbrunn, Josip Zovko, Sabrina Kraus
AKTUELLE RHEUMATOLOGIE
(2020)
Meeting Abstract
Oncology
P. Shah, T. Stuehmer, D. Bruennert, U. Munawar, M. Hudecek, E. Leich, M. Chatterjee, F. Berberich-Siebelt, R. C. Bargou, H. Einsele, T. Steinbrunn
ONCOLOGY RESEARCH AND TREATMENT
(2020)