期刊
FEBS JOURNAL
卷 286, 期 2, 页码 297-310出版社
WILEY
DOI: 10.1111/febs.14391
关键词
dendritic cells; endoplasmic reticulum; inflammation; innate immunity; unfolded protein response
资金
- CIML
- AVIESAN
- SANOFI
- 'Equipe de la Fondation de la Recherche Medicale' (FRM) [DEQ20140329536]
- l'Agence Nationale de la Recherche (ANR) [ANR-12-BSV2-0025-01, ANR-FCT12-ISV3-0002-01, INFORM Labex ANR-11-LABX-0054, DCBIOL Labex ANR-11-LABEX-0043, ANR-11-IDEX-0001-02, A*M-AAP-INME-14-01-140512-19.06-PIERRE-MLS]
- Ilidio Pinho foundation
- FCT - Fundacao para a Ciencia e a Tecnologia
- Programa Operacional Competitividade e Internacionalizacao - Compete2020 (FEDER) [PTDC/IMI-IMU/3615/2014, POCI-01-0145-FEDER-016768]
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV2-0025] Funding Source: Agence Nationale de la Recherche (ANR)
- Fundação para a Ciência e a Tecnologia [PTDC/IMI-IMU/3615/2014] Funding Source: FCT
Immune cells detect specific microbes or damage to tissue integrity in order to initiate efficient immune responses. Abnormal accumulation of proteins in the endoplasmic reticulum (ER) can be seen as a sign of cellular malfunction and stress that triggers a collection of conserved emergency rescue programs. These different signaling cascades, which favor ER proteostasis and promote cell survival, are collectively known as the unfolded protein response (UPR). In recent years, a synergy between the UPR and inflammatory cytokine production has been unraveled, with different branches of the UPR entering in a cross-talk with specialized microbe sensing pathways, which turns on or amplify inflammatory cytokines production. Complementary to this synergetic activity, UPR induction alone, can itself be seen as a danger signal, and triggers directly or indirectly inflammation in different cellular and pathological models, this independently of the presence of pathogens. Here, we discuss recent advances on the nature of these cross-talks and how innate immunity, metabolism dysregulation, and ER-signaling pathways intersect in specialized immune cells, such as dendritic cells (DCs), and contribute to the pathogenesis of inflammatory diseases.
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