Degradation of mutant p53H175 protein by Zn(II) through autophagy

Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis

(2015) Akinori Morita et al.   Oncotarget

Dissecting the pathways that destabilize mutant p53: The proteasome or autophagy?

(2013) Sujata Choundhury et al.   CELL CYCLE

Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

(2013) W Hanel et al.   CELL DEATH AND DIFFERENTIATION

Improving the bioactivity of Zn(ii)-curcumin based complexes

(2013) Daniela Pucci et al.   DALTON TRANSACTIONS

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

(2013) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The mutant p53 mouse as a pre-clinical model

(2013) J G Jackson et al.   ONCOGENE

Allele-Specific p53 Mutant Reactivation

(2012) Xin Yu et al.   CANCER CELL

p53 reactivation

(2012) Gabriella D’Orazi et al.   CELL CYCLE

Dietary downregulation of mutant p53 levels via glucose restriction

(2012) Olga Catalina Rodriguez et al.   CELL CYCLE

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

DNA binding and cytotoxicity of fluorescent curcumin-based Zn(ii) complexes

(2012) Daniela Pucci et al.   MedChemComm

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53

(2011) Kaipeng Jing et al.   Autophagy

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Mutant p53 rescue and modulation of p53 redox state

(2011) Vladimir J.N. Bykov et al.   CELL CYCLE

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs

(2011) Rosa Puca et al.   CELL CYCLE

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function

(2011) Ofer Margalit et al.   INTERNATIONAL JOURNAL OF CANCER

Mutant p53 Protein Is Targeted by Arsenic for Degradation and Plays a Role in Arsenic-mediated Growth Suppression

(2011) Wensheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Depletion of Mutant p53 by Cancer Chemopreventive Isothiocyanates and Their Structure−Activity Relationships

(2011) Xiantao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hidden order revealed

(2011) Michael E. Flatté   Nature Physics

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy

(2010) Gianluca Bossi et al.   CELL CYCLE

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

The missing Zinc: p53 misfolding and cancer

(2010) Stewart N. Loh   Metallomics

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

(2010) K G Wiman   ONCOGENE

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Targeting Hypoxia in Cancer Cells by Restoring Homeodomain Interacting Protein-Kinase 2 and p53 Activity and Suppressing HIF-1α

(2009) Lavinia Nardinocchi et al.   PLoS One

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown

(2008) R. Puca et al.   CANCER RESEARCH

Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc

(2008) Rosa Puca et al.   EXPERIMENTAL CELL RESEARCH