IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model

Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk

(2019) Amanda McQuade et al.   JOURNAL OF MOLECULAR BIOLOGY

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

(2018) Sreemathi Logan et al.   Molecular Metabolism

Involvement of Insulin-Like Growth Factor 1 Receptor Signaling in the Amyloid-β Peptide Oligomers-Induced p75 Neurotrophin Receptor Protein Expression in Mouse Hippocampus

(2018) Shingo Ito et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-Like Growth Factor-I Receptor Stimulating Activity is Associated with Dementia

(2018) Renée F.A.G. de Bruijn et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction

(2017) Rigo Cintron-Colon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer’s Disease

(2016) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

An improved approach to align and embed multiple brain samples in a gelatin-based matrix for simultaneous histological processing

(2016) Kumi Nagamoto-Combs et al.   JOURNAL OF NEUROSCIENCE METHODS

The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice

(2016) Kendra L. Puig et al.   NEUROBIOLOGY OF AGING

Association between Cognition and Serum Insulin-Like Growth Factor-1 in Middle-Aged & Older Men: An 8 Year Follow-Up Study

(2016) Shankar Tumati et al.   PLoS One

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

(2015) Evie van der Spoel et al.   Aging-US

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

(2015) Maria L. Giuffrida et al.   Frontiers in Cellular Neuroscience

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

The age factor in Alzheimer’s disease

(2015) Rita Guerreiro et al.   Genome Medicine

A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis

(2015) Sylvia Ortega-Martínez   Frontiers in Molecular Neuroscience

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

(2014) Sofiya Milman et al.   AGING CELL

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy

(2014) A. J. Westwood et al.   NEUROLOGY

A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity

(2013) Tayir El-Ami et al.   AGING CELL

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model

(2013) Edoardo Parrella et al.   AGING CELL

Longevity effect of IGF-1R+/−mutation depends on genetic background-specific receptor activation

(2013) Jie Xu et al.   AGING CELL

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Insulin-like growth factor–1 and risk of late-onset Alzheimer's disease: findings from a family study

(2013) E. van Exel et al.   NEUROBIOLOGY OF AGING

Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease

(2013) Per Johansson et al.   PSYCHONEUROENDOCRINOLOGY

Targeting the insulin-like growth factor-1 receptor in human cancer

(2013) Alexandre Arcaro   Frontiers in Pharmacology

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease

(2012) Sang-Ho Choi et al.   JOURNAL OF NEUROCHEMISTRY

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

(2011) Smita Majumder et al.   AGING CELL

Insulin/Insulin-Like Growth Factor-1 Signaling and Cognitive Function in Humans

(2011) S. M. Euser et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma

(2011) S. Yin et al.   NEURO-ONCOLOGY

Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism

(2011) Gunjan Dhawan et al.   NEUROBIOLOGY OF AGING

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

The proliferating role of insulin and insulin-like growth factors in cancer

(2010) Emily Jane Gallagher et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I

(2009) Michelle M. Adams et al.   GROWTH FACTORS

mTOR-dependent signalling in Alzheimer's disease

(2008) Jin-Jing Pei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Growth hormone secretagogue MK-677: No clinical effect on AD progression in a randomized trial

(2008) J. J. Sevigny et al.   NEUROLOGY

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY

Peripheral elevation of IGF-1 fails to alter Aβ clearance in multiple in vivo models

(2007) Thomas A. Lanz et al.   BIOCHEMICAL PHARMACOLOGY