Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

(2010) C. Lee et al.   CANCER RESEARCH

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism

(2009) Federica Madia et al.   JOURNAL OF CELL BIOLOGY

Longevity in Untreated Congenital Growth Hormone Deficiency Due to a Homozygous Mutation in the GHRH Receptor Gene

(2009) Manuel H. Aguiar-Oliveira et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes

(2008) Lydie Hlavatá et al.   AGING CELL

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

Longevity mutation inSCH9prevents recombination errors and premature genomic instability in a Werner/Bloom model system

(2008) Federica Madia et al.   JOURNAL OF CELL BIOLOGY

Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues

(2008) Ana Maria Garcia et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Turning anti-ageing genes against cancer

(2008) Valter D. Longo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA