A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity

Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment

(2013) H. Reuveni et al.   CANCER RESEARCH

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

(2013) Peichuan Zhang et al.   Cell Metabolism

A Neuronal GPCR is Critical for the Induction of the Heat Shock Response in the Nematode C. elegans

(2013) M. Maman et al.   JOURNAL OF NEUROSCIENCE

Temporal requirements of heat shock factor-1 for longevity assurance

(2012) Yuli Volovik et al.   AGING CELL

HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity

(2012) Wei-Chung Chiang et al.   CELL

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling

(2011) Tao Zhang et al.   HUMAN MOLECULAR GENETICS

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins

(2011) V. Prahlad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Extending Network of FOXO Transcriptional Target Genes

(2010) Kristan E. van der Vos et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity

(2010) Tjakko J. van Ham et al.   CELL

Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans

(2010) Gawain McColl et al.   Cell Metabolism

Countering neurodegeneration by reducing the activity of the insulin/IGF signaling pathway: Current knowledge and future prospects

(2010) Ehud Cohen   EXPERIMENTAL GERONTOLOGY

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

(2010) Jinling Wang et al.   PLoS Genetics

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

(2009) Ehud Cohen et al.   AGING CELL

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

The IRS2 Gly1057Asp Variant Is Associated With Human Longevity

(2009) M. Barbieri et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR

(2009) J. M. Carboni et al.   MOLECULAR CANCER THERAPEUTICS

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Forkhead transcription factors and ageing

(2008) L Partridge et al.   ONCOGENE

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA