The human motor cortex microcircuit: insights for neurodegenerative disease

A systematic review of MEG-based studies in Parkinson's disease: The motor system and beyond

(2019) Lennard I. Boon et al.   HUMAN BRAIN MAPPING

Targeting Huntingtin Expression in Patients with Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Layer-specific activation of sensory input and predictive feedback in the human primary somatosensory cortex

(2019) Yinghua Yu et al.   Science Advances

In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies

(2019) Alexander D Shaw et al.   CEREBRAL CORTEX

Layer-dependent activity in human prefrontal cortex during working memory

(2019) Emily S. Finn et al.   NATURE NEUROSCIENCE

A dynamical model of the laminar BOLD response

(2019) Martin Havlicek et al.   NEUROIMAGE

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model

(2019) Hans-Peter Müller et al.   Translational Neurodegeneration

Brain Regions Showing White Matter Loss in Huntington’s Disease Are Enriched for Synaptic and Metabolic Genes

(2018) Peter McColgan et al.   BIOLOGICAL PSYCHIATRY

Reorganization of cortical oscillatory dynamics underlying disinhibition in frontotemporal dementia

(2018) Laura E Hughes et al.   BRAIN

Localizing parkinsonism based on focal brain lesions

(2018) Juho Joutsa et al.   BRAIN

Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis

(2018) Malcolm Proudfoot et al.   CLINICAL NEUROPHYSIOLOGY

Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

(2018) Alex McCampbell et al.   JOURNAL OF CLINICAL INVESTIGATION

Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences

(2018) Arielle Baker et al.   JOURNAL OF NEUROSCIENCE

Glutathione and glutamate in schizophrenia: a 7T MRS study

(2018) Jyothika Kumar et al.   MOLECULAR PSYCHIATRY

Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

(2018) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Microstructural imaging of human neocortex in vivo

(2018) Luke J. Edwards et al.   NEUROIMAGE

Key clinical benefits of neuroimaging at 7 T

(2018) Siegfried Trattnig et al.   NEUROIMAGE

Clinical Reasoning: A 23-year-old woman with fever and vertical diplopia

(2018) David J. Lin et al.   NEUROLOGY

Laminar recordings in frontal cortex suggest distinct layers for maintenance and control of working memory

(2018) André M. Bastos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pros and cons of ultra-high-field MRI/MRS for human application

(2018) Mark E. Ladd et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode Schizophrenia

(2018) Meredith A Reid et al.   SCHIZOPHRENIA BULLETIN

Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS

(2018) Rebecca J Broad et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease

(2018) Ian O. Bledsoe et al.   NEUROLOGY

Cracking the Function of Layers in the Sensory Cortex

(2018) Hillel Adesnik et al.   NEURON

Lamina-specific cortical dynamics in human visual and sensorimotor cortices

(2018) James J Bonaiuto et al.   eLife

Huntington's disease: a clinical review

(2017) P. McColgan et al.   EUROPEAN JOURNAL OF NEUROLOGY

Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease

(2017) Peter McColgan et al.   HUMAN BRAIN MAPPING

Expression of Kv3.1b potassium channel is widespread in macaque motor cortex pyramidal cells: A histological comparison between rat and macaque

(2017) David Soares et al.   JOURNAL OF COMPARATIVE NEUROLOGY

An Ultrastructural Study of the Thalamic Input to Layer 4 of Primary Motor and Primary Somatosensory Cortex in the Mouse

(2017) Rita Bopp et al.   JOURNAL OF NEUROSCIENCE

Magnetoencephalography for brain electrophysiology and imaging

(2017) Sylvain Baillet   NATURE NEUROSCIENCE

Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases

(2017) Scott T. Brady et al.   NEUROBIOLOGY OF DISEASE

In-vivo magnetic resonance imaging (MRI) of laminae in the human cortex

(2017) Robert Trampel et al.   NEUROIMAGE

Cortical layers: Cyto-, myelo-, receptor- and synaptic architecture in human cortical areas

(2017) Nicola Palomero-Gallagher et al.   NEUROIMAGE

High-Resolution CBV-fMRI Allows Mapping of Laminar Activity and Connectivity of Cortical Input and Output in Human M1

(2017) Laurentius Huber et al.   NEURON

Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines

(2017) Michelle Tjia et al.   Frontiers in Neural Circuits

Spine Enlargement of Pyramidal Tract-Type Neurons in the Motor Cortex of a Rat Model of Levodopa-Induced Dyskinesia

(2017) Tatsuya Ueno et al.   Frontiers in Neuroscience

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

(2017) Hien Tran Zhao et al.   Molecular Therapy-Nucleic Acids

Pathology of callosal damage in ALS: An ex-vivo , 7 T diffusion tensor MRI study

(2017) Agustin M. Cardenas et al.   NeuroImage-Clinical

White matter predicts functional connectivity in premanifest Huntington's disease

(2017) Peter McColgan et al.   Annals of Clinical and Translational Neurology

Ultra high-field (7tesla) magnetic resonance spectroscopy in Amyotrophic Lateral Sclerosis

(2017) Nazem Atassi et al.   PLoS One

Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis

(2016) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Huntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain

(2016) U. Rüb et al.   BRAIN PATHOLOGY

Laminar Differences in Dendritic Structure of Pyramidal Neurons in the Juvenile Rat Somatosensory Cortex

(2016) Concepción Rojo et al.   CEREBRAL CORTEX

Altered cortical beta-band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis

(2016) Malcolm Proudfoot et al.   HUMAN BRAIN MAPPING

Aberrant interhemispheric homotopic functional and structural connectivity in amyotrophic lateral sclerosis

(2016) Jiuquan Zhang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyotrophic lateral sclerosis: moving towards a new classification system

(2016) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Cross-sectional and longitudinal multimodal structural imaging in prodromal Huntington's disease

(2016) Deborah L. Harrington et al.   MOVEMENT DISORDERS

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex

(2016) Nasim F. Mehrabi et al.   NEUROBIOLOGY OF DISEASE

Lamina-dependent calibrated BOLD response in human primary motor cortex

(2016) Maria Guidi et al.   NEUROIMAGE

Computational modelling of movement-related beta-oscillatory dynamics in human motor cortex

(2016) Mrudul B. Bhatt et al.   NEUROIMAGE

Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A 1H MRS Study at 7Tesla

(2016) Allison S. Brandt et al.   SCHIZOPHRENIA RESEARCH

Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson’s Disease

(2016) Janina Grosch et al.   Frontiers in Cellular Neuroscience

Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis

(2016) Matthew J. Fogarty et al.   Scientific Reports

Primary motor cortex of the parkinsonian monkey: altered encoding of active movement

(2015) Benjamin Pasquereau et al.   BRAIN

Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington’s disease

(2015) Peter McColgan et al.   BRAIN

Huntington's Disease (HD): Neurodegeneration of Brodmann's Primary Visual Area 17 (BA17)

(2015) Udo Rüb et al.   BRAIN PATHOLOGY

Prefrontal cortex white matter tracts in prodromal Huntington disease

(2015) Joy T. Matsui et al.   HUMAN BRAIN MAPPING

Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease

(2015) Rodolfo G. Gatto et al.   HUMAN MOLECULAR GENETICS

Synaptic Circuit Organization of Motor Corticothalamic Neurons

(2015) N. Yamawaki et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson's disease

(2015) Lili Guo et al.   NATURE NEUROSCIENCE

The neocortical circuit: themes and variations

(2015) Kenneth D Harris et al.   NATURE NEUROSCIENCE

Visual Areas Exert Feedforward and Feedback Influences through Distinct Frequency Channels

(2015) André Moraes Bastos et al.   NEURON

Motor cortex layer 4: less is more

(2015) Helen Barbas et al.   TRENDS IN NEUROSCIENCES

What graph theory actually tells us about resting state interictal MEG epileptic activity

(2015) Guiomar Niso et al.   NeuroImage-Clinical

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

(2015) Jacqueline C Mitchell et al.   Acta Neuropathologica Communications

Cortical interneuron loss and symptom heterogeneity in Huntington disease

(2014) Eric H. Kim et al.   ANNALS OF NEUROLOGY

Area 4 has layer IV in adult primates

(2014) Miguel Ángel García-Cabezas et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes

(2014) Adriano Chiò et al.   LANCET NEUROLOGY

Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task

(2014) Yoshito Masamizu et al.   NATURE NEUROSCIENCE

Morphological and electrophysiological changes in intratelencephalic-type pyramidal neurons in the motor cortex of a rat model of levodopa-induced dyskinesia

(2014) Tatsuya Ueno et al.   NEUROBIOLOGY OF DISEASE

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis

(2014) C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmaco-MEG evidence for attention related hyper-connectivity between auditory and prefrontal cortices in ADHD

(2014) Elizabeth Heinrichs-Graham et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Diverse cellular and molecular modes of axon degeneration

(2014) Lukas J. Neukomm et al.   TRENDS IN CELL BIOLOGY

A genuine layer 4 in motor cortex with prototypical synaptic circuit connectivity

(2014) Naoki Yamawaki et al.   eLife

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

(2013) Johannes Brettschneider et al.   ANNALS OF NEUROLOGY

Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson′s disease

(2013) Amélie C. Lanoue et al.   BRAIN RESEARCH

Synchronized neural oscillations and the pathophysiology of Parkinsonʼs disease

(2013) Ashwini Oswal et al.   CURRENT OPINION IN NEUROLOGY

Reproducibility of brain spectroscopy at 7T using conventional localization and spectral editing techniques

(2013) S. Andrea Wijtenburg et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Systematic Regional Variations of GABA, Glutamine, and Glutamate Concentrations Follow Receptor Fingerprints of Human Cingulate Cortex

(2013) W. Dou et al.   JOURNAL OF NEUROSCIENCE

Organization of Cortical and Thalamic Input to Pyramidal Neurons in Mouse Motor Cortex

(2013) B. M. Hooks et al.   JOURNAL OF NEUROSCIENCE

Prestimulus Oscillatory Activity over Motor Cortex Reflects Perceptual Expectations

(2013) F. P. de Lange et al.   JOURNAL OF NEUROSCIENCE

Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

(2013) Heiko Braak et al.   Nature Reviews Neurology

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Region-specific modulations in oscillatory alpha activity serve to facilitate processing in the visual and auditory modalities

(2013) Ali Mazaheri et al.   NEUROIMAGE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Reflections on agranular architecture: predictive coding in the motor cortex

(2013) Stewart Shipp et al.   TRENDS IN NEUROSCIENCES

Quantitative multi-parameter mapping of R1, PD*, MT, and R2* at 3T: a multi-center validation

(2013) Nikolaus Weiskopf et al.   Frontiers in Neuroscience

Prefrontal Dopamine Levels Determine the Balance between Cognitive Stability and Flexibility

(2012) S. J. Fallon et al.   CEREBRAL CORTEX

Layer-Specific Entrainment of Gamma-Band Neural Activity by the Alpha Rhythm in Monkey Visual Cortex

(2012) Eelke Spaak et al.   CURRENT BIOLOGY

Axonopathy in Huntington's disease

(2012) Jia-Yi Li et al.   EXPERIMENTAL NEUROLOGY

Hierarchical Connectivity and Connection-Specific Dynamics in the Corticospinal-Corticostriatal Microcircuit in Mouse Motor Cortex

(2012) T. Kiritani et al.   JOURNAL OF NEUROSCIENCE

Laminarly Orthogonal Excitation of Fast-Spiking and Low-Threshold-Spiking Interneurons in Mouse Motor Cortex

(2012) A. J. Apicella et al.   JOURNAL OF NEUROSCIENCE

Motor-cortical oscillations in early stages of Parkinson's disease

(2012) B. Pollok et al.   JOURNAL OF PHYSIOLOGY-LONDON

Interneuron dysfunction in psychiatric disorders

(2012) Oscar Marín   NATURE REVIEWS NEUROSCIENCE

Visual gamma oscillations: The effects of stimulus type, visual field coverage and stimulus motion on MEG and EEG recordings

(2012) S.D. Muthukumaraswamy et al.   NEUROIMAGE

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

(2012) Holly B. Kordasiewicz et al.   NEURON

Therapeutic Deep Brain Stimulation in Parkinsonian Rats Directly Influences Motor Cortex

(2012) Qian Li et al.   NEURON

Canonical Microcircuits for Predictive Coding

(2012) Andre M. Bastos et al.   NEURON

The Logic of Inhibitory Connectivity in the Neocortex

(2012) Elodie Fino et al.   NEUROSCIENTIST

Laminar analysis of visually evoked activity in the primary visual cortex

(2012) D. Xing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploratory 7-Tesla magnetic resonance spectroscopy in Huntington’s disease provides in vivo evidence for impaired energy metabolism

(2011) Simon J. A. den Bogaard et al.   JOURNAL OF NEUROLOGY

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

(2011) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease

(2011) Jeffrey B. Carroll et al.   NEUROBIOLOGY OF DISEASE

Relating MEG measured motor cortical oscillations to resting γ-Aminobutyric acid (GABA) concentration

(2011) W. Gaetz et al.   NEUROIMAGE

Dense Inhibitory Connectivity in Neocortex

(2011) Elodie Fino et al.   NEURON

Beta oscillations in the monkey sensorimotor network reflect somatosensory decision making

(2011) S. Haegens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laminar differences in gamma and alpha coherence in the ventral stream

(2011) E. A. Buffalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Oscillations in the monkey sensorimotor network influence discrimination performance by rhythmical inhibition of neuronal spiking

(2011) S. Haegens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington’s disease

(2010) Doris C. V. Thu et al.   BRAIN

GABAergic Interneuron Lineages Selectively Sort into Specific Cortical Layers during Early Postnatal Development

(2010) Goichi Miyoshi et al.   CEREBRAL CORTEX

Primary Motor Cortex of the Parkinsonian Monkey: Differential Effects on the Spontaneous Activity of Pyramidal Tract-Type Neurons

(2010) Benjamin Pasquereau et al.   CEREBRAL CORTEX

Slowing of M1 activity in Parkinson’s disease during rest and movement – An MEG study

(2010) Alistair N. Vardy et al.   CLINICAL NEUROPHYSIOLOGY

The “Dying-Back” Phenomenon of Motor Neurons in ALS

(2010) Michal Dadon-Nachum et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

(2010) Ian RA Mackenzie et al.   LANCET NEUROLOGY

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

(2010) Sarah J Tabrizi et al.   LANCET NEUROLOGY

The columnar and laminar organization of inhibitory connections to neocortical excitatory cells

(2010) Dennis Kätzel et al.   NATURE NEUROSCIENCE

Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex

(2010) Charles T Anderson et al.   NATURE NEUROSCIENCE

Intracortical cartography in an agranular area

(2010) Gordon M. G. Shepherd   Frontiers in Neuroscience

Two Types of Thalamocortical Projections from the Motor Thalamic Nuclei of the Rat: A Single Neuron-Tracing Study Using Viral Vectors

(2009) Eriko Kuramoto et al.   CEREBRAL CORTEX

Buildup of Choice-Predictive Activity in Human Motor Cortex during Perceptual Decision Making

(2009) Tobias H. Donner et al.   CURRENT BIOLOGY

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

(2009) Sarah J Tabrizi et al.   LANCET NEUROLOGY

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology of Parkinsonism

(2008) Adriana Galvan et al.   CLINICAL NEUROPHYSIOLOGY

Top-down laminar organization of the excitatory network in motor cortex

(2008) Nicholas Weiler et al.   NATURE NEUROSCIENCE

Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease

(2008) J. Spampanato et al.   NEUROSCIENCE

Pharmacologically induced and stimulus evoked rhythmic neuronal oscillatory activity in the primary motor cortex in vitro

(2007) N. Yamawaki et al.   NEUROSCIENCE