Article
Neurosciences
Molly Simmonite, Clara J. Steeby, Stephan F. Taylor
Summary: GABA abnormalities may contribute to the pathophysiology of psychosis spectrum and mood disorders. Lower GABA levels were found in the mid- and posterior medial frontal cortex of schizophrenia patients, while increased GABA levels were observed in the rostral medial frontal cortex of bipolar disorder patients.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Behavioral Sciences
Simon Maier, Ansgard Lena Dueppers, Kimon Runge, Michael Dacko, Thomas Lange, Thomas Fangmeier, Andreas Riedel, Dieter Ebert, Dominique Endres, Katharina Domschke, Evgeniy Perlov, Kathrin Nickel, Ludger Tebartz van Elst
Summary: Adults with autism spectrum disorders have elevated levels of the inhibitory neurotransmitter GABA in the left dorsolateral prefrontal cortex. This finding supports the hypothesis of an imbalance between excitatory and inhibitory equilibrium in patients with autism spectrum disorders.
Article
Neurosciences
Meng Li, Lena Vera Danyeli, Lejla Colic, Gerd Wagner, Stefan Smesny, Tara Chand, Xin Di, Bharat B. Biswal, Jorn Kaufmann, Juergen R. Reichenbach, Oliver Speck, Martin Walter, Zuemruet Duygu Sen
Summary: Reproducible resting-state functional connectivity patterns and their alterations have significant implications in neuropsychiatric research. This study utilizes multimodal imaging and magnetic resonance spectroscopy to investigate the correlation between regional neurotransmitter levels and rsFC strength, providing insights into the modulation of interaction between brain regions at a macroscopic level.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Dana Marafi, Jawid M. Fatih, Rauan Kaiyrzhanov, Matteo P. Ferla, Charul Gijavanekar, Aljazi Al-Maraghi, Ning Liu, Emily Sites, Hessa S. Alsaif, Mohammad Al-Owain, Mohamed Zakkariah, Ehab El-Anany, Ulviyya Guliyeva, Sughra Guliyeva, Colette Gaba, Ateeq Haseeb, Amal M. Alhashem, Enam Danish, Vasiliki Karageorgou, Christian Beetz, Alaa A. Subhi, Sureni Mullegama, Erin Torti, Monisha Sebastin, Margo Sheck Breilyn, Susan Duberstein, Mohamed S. Abdel-Hamid, Tadahiro Mitani, Haowei Du, Jill A. Rosenfeld, Shalini N. Jhangiani, Zeynep Coban Akdemir, Richard A. Gibbs, Jenny C. Taylor, Khalid A. Fakhro, Jill Hunter, Davut Pehlivan, Maha S. Zaki, Joseph G. Gleeson, Reza Maroofian, Henry Houlden, Jennifer E. Posey, V. Reid Sutton, Fowzan S. Alkuraya, Sarah H. Elsea, James R. Lupski
Summary: SLC38A3 is a novel disease gene for developmental and epileptic encephalopathy, and the likely pathophysiology of the disease is perturbations in glutamine homeostasis.
Article
Biochemistry & Molecular Biology
Corinne S. Wilson, Preeti Dohare, Shaina Orbeta, Julia W. Nalwalk, Yunfei Huang, Russell J. Ferland, Rajan Sah, Annalisa Scimemi, Alexander A. Mongin
Summary: The knockout of the LRRC8A gene in mice leads to seizures in adolescence, as well as abnormalities in neurons and astrocytes in the brain. These abnormalities are associated with reactive astrogliosis, as well as dysregulation of amino acid neurotransmitter uptake and supply by astrocytes.
Article
Pharmacology & Pharmacy
Chuqiao Pan, Shijie Mao, Zeping Xiong, Zhao Chen, Ning Xu
Summary: Glutamate dehydrogenase (GDH) is a key enzyme in mammalian glutamate metabolism, participating in multiple metabolic pathways and cellular activities. Its dysfunction may lead to various neurodegenerative diseases. Activators and gene therapy targeting GDH have shown potential in protecting neurons and improving motor disorders caused by glutamate metabolism disorders. This approach offers new insights and treatment strategies for neurodegenerative diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Jens Andersen, Sofie K. Christensen, Emil W. Westi, Marta Diaz-delCastillo, Heikki Tanila, Arne Schousboe, Blanca Aldana, Helle S. Waagepetersen
Summary: This study found that in Alzheimer's disease (AD), there is prominent neuronal hypometabolism in the hippocampal slices of affected mice, while a reduction in glutamine synthesis in astrocytes directly impedes neuronal GABA synthesis.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Petr Bednarik, Benjamin Spurny, Leo R. Silberbauer, Alena Svatkova, Patricia A. Handschuh, Birgit Reiter, Melisande E. Konadu, Thomas Stimpfl, Marie Spies, Wolfgang Bogner, Rupert Lanzenberger
Summary: This study utilized state-of-the-art H-1-MRS methodology to assess the effects of ketamine on neurochemicals in the posterior cingulate cortex (PCC). While no delayed glutamatergic responses to ketamine were detected in PCC within 3 hours, the study provides valuable insights into the relationship between ketamine's antidepressant effect and disturbed connectivity patterns in this brain region.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Narayan D. Soni, Akila Ramesh, Dipak Roy, Anant B. Patel
Summary: Alzheimer's disease is a common neurodegenerative disorder, and the ICV-STZ model exhibits typical neurometabolic deficits observed in AD, suggesting its utility in understanding the mechanism of sporadic AD.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Psychiatry
Balwinder Singh, John D. Port, Jennifer L. Vande Voort, Brandon J. Coombes, Jennifer R. Geske, Ian R. Lanza, Robert J. Morgan, Mark A. Frye
Summary: The neurotransmitters GABA and glutamate have been linked to depression and the antidepressant response to ketamine. A study on treatment-resistant depression patients showed a correlation between ketamine's effectiveness and GABA levels in the anterior cingulate cortex, suggesting a potential biomarker for ketamine response.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, General & Internal
Juan Guo, Mingzi Ran, Zilong Gao, Xinxin Zhang, Dan Wang, Huiming Li, Shiyi Zhao, Wenzhi Sun, Hailong Dong, Ji Hu
Summary: The study reveals that during anaesthetic-induced loss of consciousness, there is a general decrease in cortical GABA transmission and variations in glutamate transmission among different cell types, indicating a disrupted excitatory-inhibitory network leading to consciousness loss.
Article
Behavioral Sciences
Ilias Chaibi, Otmane Bouchatta, Mohamed Bennis, Saadia Ba-M'hamed
Summary: Aggression is a complex social behavior that evolves from the need to defend territory, compete for resources and mates. While aggression is considered negative, it is essential for many species. Understanding the neural basis of aggression, specifically the involvement of the anterior cingulate cortex (ACC), is important. This review summarizes current knowledge on the neurobiology of aggression and impulsivity related to the ACC, including structural, neuroanatomical, neurochemical, and neuropharmacological studies.
BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Xiaona Fu, Mengting Qin, Xiaoming Liu, Lan Cheng, Lan Zhang, Xinli Zhang, Yu Lei, Qidong Zhou, Peng Sun, Liangjie Lin, Ying Su, Jing Wang
Summary: This study investigated the relationship between GABA levels, cortical thickness, and executive function in MCI patients. The results showed that MCI patients had lower GABA+/Cr levels in the ACC and PCC, while there were no differences in cortical thickness between the two groups. Therefore, GABA in the ACC and PCC could be a potential diagnostic marker for the decline in executive function in MCI.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Ilias Chaibi, Mohamed Bennis, Saadia Ba-Mhamed
Summary: The study revealed the role of GABA-A receptor in the anterior cingulate cortex in regulating aggression, social, and anxiety-related behaviors in socially isolated mice. Muscimol increased these behaviors, while bicuculline reduced hyper-aggressive behavior and enhanced social behavior.
Article
Clinical Neurology
Niels T. de Joode, Anders L. Thorsen, Eline L. Vester, Chris Vriend, Petra J. W. Pouwels, Kristen Hagen, Olga T. Ousdal, Bjarne Hansen, Gerd Kvale, Odile A. van den Heuvel
Summary: The study found no abnormalities in neurometabolites in the dACC of OCD patients before treatment or over time, and the changes induced by ERP treatment seem to depend more on comorbid mood disorders and disease stage rather than OCD itself.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Stefanie Schreiber, Anna-Charlotte John, Cornelius J. Werner, Stefan Vielhaber, Hans-Jochen Heinze, Oliver Speck, Jens Wuerfel, Daniel Behme, Hendrik Mattern
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Melanie Storch, Maria Kanthack, Till Amelung, Klaus M. Beier, Tillmann H. C. Krueger, Christopher Sinke, Henrik Walter, Martin Walter, Boris Schiffer, Stephanie Schindler, Peter Schoenknecht
Summary: The study highlights the importance of differentiating between sexual offending and paraphilic sexual preferences, as a deviant hypothalamic structure was found to be a neurobiological correlate of child sexual offenses in pedophiles but not in individuals with pedophilia who have not committed offenses.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Saskia Esmee Nijmeijer, Marie-Jose van Tol, Andre Aleman, Merel Keijzer
Summary: This study investigates the relationship between musical and multilingual experiences and cognition and well-being in older adults. It found that high multilingual experience is related to better cognitive performance, but not to more positive affect. However, combining musical and high multilingual experiences is related to better cognitive performance and more positive affect, independently of age, education level, and socioeconomic status.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Biophysics
Johannes Petzold, Sebastian Schmitter, Berk Silemek, Lukas Winter, Oliver Speck, Bernd Ittermann, Frank Seifert
Summary: This study integrates the safety assessment of implant carriers in MRI with pTx technology. It proposes a comprehensive safety concept that combines real-time monitoring with physical sensors for quantifying implant-related heating. Simulation experiments and optimization algorithms are used to find the best excitation scheme that ensures both overall and local safety.
NMR IN BIOMEDICINE
(2023)
Article
Biology
Hana Haseljic, Soumick Chatterjeeb, Robert Frysch, Vojtech Kulvait, Vladimir Semshchikov, Bennet Hensenj, Frank Wackerj, Inga Brueschk, Thomas Wernckej, Oliver Speck, Andreas Nuernberger, Georg Rose
Summary: Model-based reconstruction with TST improves dynamic perfusion imaging of the liver using CBCT. Accurate liver segmentation is required for applying TST with prior knowledge from CT perfusion data. Turbolift learning sequentially trains a modified Attention UNet on different liver segmentation tasks, achieving significant improvement in liver segmentation from CBCT TST. This research demonstrates the potential of segmenting the liver from CT, CBCT, and CBCT TST for visualizing and evaluating perfusion maps in liver disease treatment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Thania Balducci, Eduardo A. Garza-Villarreal, Alely Valencia, Andre Aleman, Marie-Jose van Tol
Summary: This study aimed to investigate brain activation and functional connectivity during processing of emotional stimuli in patients with fibromyalgia. The results showed that the left superior lateral occipital cortex exhibited higher activation in fibromyalgia patients compared to healthy controls during emotion processing. Additionally, there was an interaction effect between the left pregenual anterior cingulate cortex and several other brain regions. These findings suggest abnormal brain activation and connectivity underlying emotion processing in fibromyalgia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Review
Health Care Sciences & Services
Wenrui Deng, Rianne M. J. J. van der Kleij, Hongxia Shen, Junjie Wei, Evelyn A. Brakema, Nick Guldemond, Xiaoyue Song, Xiaoming Li, Marie-Jose van Tol, Andre Aleman, Niels H. Chavannes
Summary: Insomnia is a prevalent public health problem worldwide. eHealth-based psychosocial interventions have been found to be effective in reducing insomnia severity and improving sleep quality. The integration of eHealth interventions in a stepped-care model and the use of blended care can further enhance treatment effectiveness.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychiatry
Rozemarijn S. van Kleef, Pallavi Kaushik, Marlijn Besten, Jan-Bernard C. Marsman, Claudi L. H. Bockting, Marieke van Vugt, Andre Aleman, Marie-Jose van Tol
Summary: This study investigated the persistence of abnormalities in self-referential cognitions and functioning of associated brain networks in remitted recurrent MDD patients and their predictive value for relapse. The results showed no significant differences between remitted patients and controls in self-associations and resting-state functional connectivity. However, relapse was related to baseline functional connectivity, implicit self-associations, and uncontrollability of ruminative thinking. These findings suggest that variations in self-related processing play a role in the vulnerability to developing recurrent depressive episodes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Philipp Ernst, Soumick Chatterjee, Georg Rose, Oliver Speck, Andreas Nuernberger
Summary: Computed tomography (CT) and magnetic resonance imaging (MRI) are widely used clinical imaging modalities for non-invasive diagnosis, but both have certain problems. This paper proposes a unified solution for sparse CT and undersampled radial MRI reconstruction and improves the accuracy and reconstruction speed of the Primal-Dual network.
Article
Neurosciences
Luisa Herrmann, Johanna Ade, Anne Kuehnel, Annina Widmann, Liliana Ramona Demenescu, Meng Li, Nils Opel, Oliver Speck, Martin Walter, Lejla Colic
Summary: High childhood emotional maltreatment (CM-EMO) is associated with an increased risk for psychopathology, potentially through alterations in gamma-Aminobutyric acid (GABA). The pregenual anterior cingulate cortex (pgACC) is an important brain region for emotion processing, and its' GABA levels are implicated in mood and anxiety disorders. This study examined the association between self-reported CM-EMO in adulthood and GABA+ levels in the pgACC, finding a negative relationship between CM-EMO-NEG and GABA+/tCr in the pgACC.
NEUROBIOLOGY OF STRESS
(2023)
Article
Psychology, Clinical
Marlijn E. Besten, Marie-Jose van Tol, Jacolien van Rij, Marieke K. van Vugt
Summary: This study combined paradigms and techniques from cognitive sciences and experimental clinical psychology to investigate the adjustability of repetitive negative thinking. The findings suggest that the use of positive fantasizing may help counter stress-induced negative thinking, which could be useful in the treatment of depression and other disorders characterized by maladaptive thinking.
JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Petzold, Sebastian Schmitter, Berk Silemek, Lukas Winter, Oliver Speck, Bernd Ittermann, Frank Seifert
Summary: This study investigates the safety and performance aspects of parallel-transmit RF control modes for a body coil at B-0 <= 3T using electromagnetic simulations. The results show that PTx body coils can be used safely at B-0 <= 3T, but uncertainties in patient anatomy must be taken into account.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Respiratory System
Mariia Anikeeva, Maitreyi Sangal, Oliver Speck, Graham Norquay, Maaz Zuhayra, Ulf Luetzen, Josh Peters, Olav Jansen, Jan-Bernd Hoevener
Summary: This article reviews the methods and applications of pulmonary MRI using hyperpolarized xenon-129 (Xe-MRI). Hyperpolarization amplifies the signal from xenon-129, and special programming allows for visualization of ventilation, microstructure, and gas exchange in the lungs. Xe-MRI provides noninvasive, in vivo, and rapid assessment of lung health.
ZEITSCHRIFT FUR PNEUMOLOGIE
(2022)