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Neurosciences
Tracy S. Gertler, Suraj Cherian, Jean-Marc Dekeyser, Jennifer A. Kearney, Alfred L. George
Summary: Pathogenic variants in KCNT1 gene are associated with intractable epilepsy and may drive the development of epilepsy through alterations in inhibitory signaling and neuronal excitability.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biology
Ling Kang, Jonas Ranft, Vincent Hakim
Summary: This article presents a simple model of motor cortex that accurately reproduces the statistical characteristics of recorded data during movement preparation. The model suggests that traveling waves in the motor cortex are result of the dephasing caused by external inputs rather than solely a product of recurrent connectivity.
Article
Biology
Ludovica Bachschmid-Romano, Nicholas G. Hatsopoulos, Nicolas Brunel, Joern Diedrichsen
Summary: This study develops a recurrent neural network model to explain the covariation patterns between neuronal activity and motion direction in the primary motor cortex. The preferred directions of neurons and the strength of recurrent connections play crucial roles in shaping these patterns. The model suggests that external inputs drive the dynamics during movement preparation, while strong direction-specific recurrent connectivity dominates during movement execution.
Article
Biology
Sergio Oscar Verduzco-Flores, Erik De Schutter
Summary: In this paper, the importance of feedback control in understanding neural dynamics of sensorimotor control is demonstrated using a minimal model. The model shows the ability to learn and perform reaching movements, and exhibits emergent properties such as directional tuning and oscillatory dynamics.
Article
Cell Biology
E. Dominguez-Sala, L. Valdes-Sanchez, S. Canals, O. Reiner, A. Pombero, R. Garcia-Lopez, A. Estirado, D. Pastor, E. Geijo-Barrientos, S. Martinez
Summary: LIS1 (PAFAH1B1) plays a major role in the developing cerebral cortex and mutations in this gene can cause lissencephaly type 1. Research on mutant mice with a deletion in the first exon of the Lis1 gene revealed abnormal distribution and functional abnormalities in cortical GABAergic interneurons. Additionally, these mice exhibited altered oscillatory activity and abnormalities in the fast spiking inhibitory GABAergic interneurons. These findings suggest that certain mutations in the Lis1 gene can lead to phenotypes similar to those observed in patients with schizophrenia and autism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Shreya Saxena, Abigail A. Russo, John Cunningham, Mark M. Churchland
Summary: Learned movements can be performed at different speeds, and the flexibility of these movements can be predicted and understood through neural strategies and network modeling. The study found that neural signals in the motor cortex reflect network-level strategies for generating muscle activity, rather than the muscle activity itself. This understanding of cortical activity is crucial for achieving smooth and precise control over movement speed.
Article
Psychiatry
Maria L. Serradas, Valentin Stein, Anne-Kathrin Gellner
Summary: Chronic stress is a major risk factor for mental illnesses and cognitive deficiencies. This study establishes a connection between chronic social defeat stress and impaired motor learning abilities in mice. Structural changes in the interneuronal circuits of the primary motor cortex were observed, suggesting a role in controlling excitatory output and spine dynamics.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Sonia Maatoug, Amani Cheikh, Oussema Khamessi, Hager Tabka, Zied Landoulsi, Jean-Marie Guigonis, Sylvie Diochot, Said Bendahhou, Rym Benkhalifa
Summary: This study focused on the characterization of the component in the scorpion venom AahG50 that selectively blocks Kv3.1 channels, identifying the peptide alpha-KTx 15.1 as the first scorpion venom toxin inhibiting Kv3.1 current. By occluding the Kv3.1 channel pore through the lysine 27 lateral chain, alpha-KTx 15.1 demonstrates potential as a starting compound for developing therapeutic biomolecules against Kv3.1-associated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Cecilia Gallego-Carracedo, Matthew G. Perich, Raeed H. Chowdhury, Lee E. Miller, Juan alvaro Gallego, Srdjan Ostojic
Summary: This study investigates the relationship between latent dynamics and local field potentials (LFPs), and finds that this relationship remains stable throughout behavior, bridging the gap between studies on neural correlates of behavior using different types of recordings.
Article
Neurosciences
Zuzanna Z. Balewski, Eric B. Knudsen, Joni D. Wallis
Summary: This study reveals that animals use both fast and slow decision-making processes when making value-based decisions. Rapid orienting eye movements are guided by a signal in the caudate nucleus, while a deliberative system in the orbitofrontal cortex represents the values of available options. These two processes are largely independent from each other.
Article
Biology
Fadi A. Issa, M. Kristen Hall, Cody J. Hatchett, Douglas A. Weidner, Alexandria C. Fiorenza, Ruth A. Schwalbe
Summary: This study investigates the role of N-glycans in modulating potassium channel function in highly repetitive firing neurons, showing that N-glycosylation processing of Kv3.1b regulates neuronal development and excitability, thereby controlling motor activity. The replacement of complex N-glycans with oligomannose on Kv3.1b results in slowed opening and closing rates of Kv3 channels, suggesting a reduction in intrinsic dynamics of the Kv3.1b alpha-subunit.
Article
Biology
Lucija Rapan, Sean Froudist-Walsh, Meiqi Niu, Ting Xu, Ling Zhao, Thomas Funck, Xiao-Jing Wang, Katrin Amunts, Nicola Palomero-Gallagher
Summary: Based on quantitative analyses, this study identified 35 prefrontal areas and revealed regional differences in receptor densities. Additionally, functional connectivity analyses showed distinct patterns in frontal lobe areas. The study provides comprehensive insights into the molecular structure underlying the organization of the cortex and reconciles discrepancies between structural and functional organization.
Article
Neurosciences
Kanghoon Jung, Minhyeok Chang, Andre Steinecke, Benjamin Burke, Youngjin Choi, Yasuhiro Oisi, David Fitzpatrick, Hiroki Taniguchi, Hyung-Bae Kwon
Summary: Chandelier cells (ChCs), a type of inhibitory interneurons, establish cortical microcircuits to organize neural coding through selective synaptic plasticity. They contribute to organized motor control by enhancing population coding of direction-tuned premotor neurons, with tuning refined through suppression of irrelevant activity. ChCs mediate learning by establishing inhibitory circuit motifs over individual pyramidal neurons and redistributing inhibitory weights during learning, allowing for efficient cortical computation.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Catherine Fleitas, Pau Marfull-Oromi, Disha Chauhan, Daniel del Toro, Blanca Peguera, Bahira Zammou, Daniel Rocandio, Rudiger Klein, Carme Espinet, Joaquim Egea
Summary: Neuron migration is important in nervous system development, with FLRTs controlling the distribution of cortical inhibitory interneurons through Unc5 receptors, potentially impacting the development of psychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ildiko Piszar, Magor L. Lorincz
Summary: Serotonin plays an important role in regulating sensory inputs in the olfactory cortex by modulating synaptic transmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Stephan Waldert, Ganesh Vigneswaran, Roland Philipp, Roger N. Lemon, Alexander Kraskov
JOURNAL OF NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Florian Mormann, Simon Kornblith, Moran Cerf, Matias J. Ison, Alexander Kraskov, Michelle Tran, Simeon Knieling, Rodrigo Quian Quiroga, Christof Koch, Itzhak Fried
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemistry & Molecular Biology
Ganesh Vigneswaran, Roland Philipp, Roger N. Lemon, Alexander Kraskov
Article
Neurosciences
J. M. Kilner, A. Kraskov, R. N. Lemon
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Article
Neurosciences
L. Firmin, P. Field, M. A. Maier, A. Kraskov, P. A. Kirkwood, K. Nakajima, R. N. Lemon, M. Glickstein
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Article
Neurosciences
Marsha M. Quallo, Alexander Kraskov, Roger N. Lemon
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Stephan Waldert, Roger N. Lemon, Alexander Kraskov
JOURNAL OF PHYSIOLOGY-LONDON
(2013)
Article
Neurosciences
Rodrigo Quian Quiroga, Alexander Kraskov, Florian Mormann, Itzhak Fried, Christof Koch
Article
Biology
A. Kraskov, R. Philipp, S. Waldert, G. Vigneswaran, M. M. Quallo, R. N. Lemon
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2014)
Article
Neurosciences
Alexander Kraskov, Stuart Baker, Demetris Soteropoulos, Peter Kirkwood, Roger Lemon
Article
Neurosciences
Jonathan D. Clayden, David L. Thomas, Alexander Kraskov
Article
Biology
Steven Jack Jerjian, Maneesh Sahani, Alexander Kraskov
Article
Neurosciences
Roger N. Lemon, Stuart N. Baker, Alexander Kraskov
Summary: Many investigators are using spike shape parameters, particularly spike duration, to classify different neuronal sub-types. Direct validation of spike characteristics belonging to specific types of neurons is difficult, especially with nonhuman primates. Further studies are needed to validate spike duration as a means of cell classification and relate it to histological differences in cell types.
Article
Neurosciences
A. Kraskov, D. S. Soteropoulos, I. S. Glover, R. N. Lemon, S. N. Baker