Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models

(2017) Xiaomin Su et al.   MOLECULAR THERAPY

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial

(2015) C. Warren Olanow et al.   ANNALS OF NEUROLOGY

Cell-based therapies for Parkinson disease—past insights and future potential

(2015) Roger A. Barker et al.   Nature Reviews Neurology

Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies

(2015) R.T. Bartus et al.   NEUROBIOLOGY OF DISEASE

Treatment of Parkinson's disease using cell transplantation

(2015) Olle Lindvall   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rebuilding the nigrostriatal dopamine pathway: 30 years and counting

(2014) Timothy J. Collier   EXPERIMENTAL NEUROLOGY

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Trophic Factor Gene Therapy for Parkinson's Disease

(2013) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration

(2011) Sang Ryong Kim et al.   ANNALS OF NEUROLOGY

Neuronal Intrinsic Mechanisms of Axon Regeneration

(2011) Kai Liu et al.   Annual Review of Neuroscience

AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth

(2011) Sang Ryong Kim et al.   MOLECULAR THERAPY

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors

(2010) Xiaomin Su et al.   MOLECULAR THERAPY

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Establishment of Axon-Dendrite Polarity in Developing Neurons

(2009) Anthony P. Barnes et al.   Annual Review of Neuroscience

Involvement of Akt in neurite outgrowth

(2009) Danielle E. Read et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain

(2009) Lachlan H. Thompson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants

(2009) Afsaneh Gaillard et al.   NEUROBIOLOGY OF DISEASE

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

(2008) Vincent Ries et al.   JOURNAL OF NEUROCHEMISTRY

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

(2008) William J Marks et al.   LANCET NEUROLOGY

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE