Selectins—The Two Dr. Jekyll and Mr. Hyde Faces of Adhesion Molecules—A Review

Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

(2019) Geert van Weelden et al.   Marine Drugs

A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation

(2019) Zhishuai Ye et al.   MEDIATORS OF INFLAMMATION

PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions

(2019) Xiaona Huang et al.   Protein & Cell

Design and synthesis of glycomimetics: Recent advances

(2019) Alice Tamburrini et al.   MEDICINAL RESEARCH REVIEWS

Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment

(2019) Heidi Harjunpää et al.   Frontiers in Immunology

Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis

(2019) Heinz Läubli et al.   Frontiers in Immunology

Cancer glycan epitopes: biosynthesis, structure and function

(2018) Oliver M T Pearce   GLYCOBIOLOGY

E-Selectin Ligands in the Human Mononuclear Phagocyte System: Implications for Infection, Inflammation, and Immunotherapy

(2018) Mariana Silva et al.   Frontiers in Immunology

Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids

(2018) Torben Heise et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sialylation is involved in cell fate decision during development, reprogramming and cancer progression

(2018) Fenjie Li et al.   Protein & Cell

Selectins in cancer immunity

(2017) Lubor Borsig   GLYCOBIOLOGY

Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology

(2017) Mariana Silva et al.   JOURNAL OF IMMUNOLOGY

Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide

(2017) Jian Guo et al.   JOURNAL OF MEDICINAL CHEMISTRY

PSGL-1: A New Player in the Immune Checkpoint Landscape

(2017) Roberto Tinoco et al.   TRENDS IN IMMUNOLOGY

P-, but not E- or L-, selectin-mediated rolling adhesion persistence in hemodynamic flow diverges between metastatic and leukocytic cells

(2017) Erin Elizabeth Edwards et al.   Oncotarget

Polymeric Selectin Ligands Mimicking Complex Carbohydrates: From Selectin Binders to Modifiers of Macrophage Migration

(2016) Kai E. Moog et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sialyltransferase inhibition and recent advances

(2016) Libo Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Binding free energy calculations on E-selectin complexes with sLex oligosaccharide analogs

(2016) Pabla A. Barra et al.   Chemical Biology & Drug Design

Uncharged nucleoside inhibitors of β-1,4-galactosyltransferase with activity in cells

(2016) Jingqian Jiang et al.   CHEMICAL COMMUNICATIONS

Discovery of New E-Selectin Inhibitors by Virtual Screening, Fluorescence Binding Assays, and STD NMR Experiments

(2016) Pabla A. Barra et al.   ChemMedChem

Aceclofenac: Species-Dependent Metabolism and Newer Paradigm Shift from Oral to Non-oral Delivery

(2016) Gajanand Sharma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force

(2016) Padmaja Mehta-D'souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different QM/MM Approaches To Elucidate Enzymatic Reactions: Case Study on ppGalNAcT2

(2016) Pavel Janoš et al.   Journal of Chemical Theory and Computation

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities

(2016) Rémi Szabo et al.   MEDICINAL RESEARCH REVIEWS

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

(2016) Y. Shamay et al.   Science Translational Medicine

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

(2016) Trevor T. Price et al.   Science Translational Medicine

Targeting Selectins and Their Ligands in Cancer

(2016) Alessandro Natoni et al.   Frontiers in Oncology

Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer

(2016) Alejandro J. Cagnoni et al.   Frontiers in Oncology

Transition States and Transition State Analogue Interactions with Enzymes

(2015) Vern L. Schramm   ACCOUNTS OF CHEMICAL RESEARCH

Transition state theory for enzyme kinetics

(2015) Donald G. Truhlar   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Computational Evidence for the Catalytic Mechanism of Tyrosylprotein Sulfotransferases: A Density Functional Theory Investigation

(2015) Tainah Dorina Marforio et al.   BIOCHEMISTRY

Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

(2015) M. J. Telen et al.   BLOOD

Atomistic insight into the catalytic mechanism of glycosyltransferases by combined quantum mechanics/molecular mechanics (QM/MM) methods

(2015) Igor Tvaroška   CARBOHYDRATE RESEARCH

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice

(2015) Reza Abdi et al.   STEM CELLS

E-selectin ligand complexes adopt an extended high-affinity conformation

(2015) Roland C. Preston et al.   Journal of Molecular Cell Biology

Stepwise Catalytic Mechanism via Short-Lived Intermediate Inferred from Combined QM/MM MERP and PES Calculations on Retaining Glycosyltransferase ppGalNAcT2

(2015) Tomáš Trnka et al.   PLoS Computational Biology

Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity

(2014) Dibyendu Samanta et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

(2014) Samy Cecioni et al.   CHEMICAL REVIEWS

Systemic Blockade of Sialylation in Mice with a Global Inhibitor of Sialyltransferases

(2014) Matthew S. Macauley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fucoidan as a Marine Anticancer Agent in Preclinical Development

(2014) Jong-Young Kwak   Marine Drugs

Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases

(2014) Lauren Tedaldi et al.   MedChemComm

Acyclic Tethers Mimicking Subunits of Polysaccharide Ligands: Selectin Antagonists

(2014) Mickael Calosso et al.   ACS Medicinal Chemistry Letters

Topical Delivery of Aceclofenac: Challenges and Promises of Novel Drug Delivery Systems

(2014) Kaisar Raza et al.   Biomed Research International

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans

(2013) Bernd Kuhn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Selective inhibition of glycosyltransferases by bivalent imidazolium salts

(2013) Yin Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

Development of fucosyltransferase and fucosidase inhibitors

(2013) Zhijay Tu et al.   CHEMICAL SOCIETY REVIEWS

A QM/MM Investigation of the Catalytic Mechanism of Metal-Ion-Independent Core 2 β1,6-N-Acetylglucosaminyltransferase

(2013) Igor Tvaroška et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Exposure assessment of lovastatin in Pu-erh tea

(2013) Zhen-Jun Zhao et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Competition between Core-2 GlcNAc-transferase and ST6GalNAc-transferase Regulates the Synthesis of the Leukocyte Selectin Ligand on Human P-selectin Glycoprotein Ligand-1

(2013) Chi Y. Lo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Base-modified Donor Analogues Reveal Novel Dynamic Features of a Glycosyltransferase

(2013) René Jørgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic Basis forN-Glycan Sialylation

(2013) Lu Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metastasis-promoting roles of tumor-associated immune cells

(2013) Heath A. Smith et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Understanding Selectin Counter-Receptor Binding from Electrostatic Energy Computations and Experimental Binding Studies

(2013) Anna Lena Woelke et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Nanomolar E-Selectin Antagonists with Prolonged Half-Lives by a Fragment-Based Approach

(2013) Jonas Egger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction

(2013) Takamasa Teramoto et al.   Nature Communications

Chemoenzymatic Synthesis of GDP-L-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors

(2012) Yu-Nong Lin et al.   ADVANCED SYNTHESIS & CATALYSIS

Sialyl Lewisx: A “Pre-Organized Water Oligomer”?

(2012) Florian P. C. Binder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer

(2012) Katrin Stübke et al.   CANCER LETTERS

Metabolic Inhibition of Sialyl-Lewis X Biosynthesis by 5-Thiofucose Remodels the Cell Surface and Impairs Selectin-Mediated Cell Adhesion

(2012) Wesley F. Zandberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Galactosyltransferases by a Novel Class of Donor Analogues

(2012) Karine Descroix et al.   JOURNAL OF MEDICINAL CHEMISTRY

Upregulation of β-1,4-Galactosyltransferase I in Rat Spinal Cord with Experimental Autoimmune Encephalomyelitis

(2012) Jianmei Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Recent Progress on Fucosyltransferase Inhibitors

(2012) Pedro Merino et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

(2012) Cory D Rillahan et al.   Nature Chemical Biology

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

(2012) Tracey M Gloster et al.   Nature Chemical Biology

Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD

(2012) Henrik Watz et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

A New Approach to Explore the Binding Space of Polysaccharide-Based Ligands: Selectin Antagonists

(2012) Mickael Calosso et al.   ACS Medicinal Chemistry Letters

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

(2012) M. Labelle et al.   Cancer Discovery

Neutrophil arrest by LFA-1 activation

(2012) Craig T. Lefort et al.   Frontiers in Immunology

Glycomechanics of the Metastatic Cascade: Tumor Cell–Endothelial Cell Interactions in the Circulation

(2011) Yue Geng et al.   ANNALS OF BIOMEDICAL ENGINEERING

Glycoengineering of HCELL, the Human Bone Marrow Homing Receptor: Sweetly Programming Cell Migration

(2011) Robert Sackstein   ANNALS OF BIOMEDICAL ENGINEERING

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells

(2011) J. S. Merzaban et al.   BLOOD

Pre-organization of the Core Structure of E-Selectin Antagonists

(2011) Daniel Schwizer et al.   CHEMISTRY-A EUROPEAN JOURNAL

The biology of CD44 and HCELL in hematopoiesis: the ‘step 2-bypass pathway’ and other emerging perspectives

(2011) Robert Sackstein   CURRENT OPINION IN HEMATOLOGY

Interactions between endothelial selectins and cancer cells regulate metastasis

(2011) Catherine A. et al.   Frontiers in Bioscience-Landmark

Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin

(2011) E. O. KOZLOWSKI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation

(2011) Sachie Hiratsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bases moleculares de las interacciones leucocito-endotelio durante la respuesta inflamatoria

(2011) Olga Barreiro et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Rolling Cell Adhesion

(2010) Rodger P. McEver et al.   Annual Review of Cell and Developmental Biology

The Synergy of 6-O-Sulfation andN- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion

(2010) Ruifei WANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

(2010) Y. Kuwano et al.   BLOOD

Thermodynamics and chemical characterization of protein–carbohydrate interactions: The multivalency issue

(2010) Michael Reynolds et al.   COMPTES RENDUS CHIMIE

Selectin inhibitors: a patent review

(2010) Patricia W Bedard et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Current trends in the structure-activity relationships of sialyltransferases

(2010) M. Audry et al.   GLYCOBIOLOGY

A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling

(2010) Chi-Hsiang Chiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An Efficient Approach to the Discovery of Potent Inhibitors against Glycosyltransferases

(2010) Kensaku Hosoguchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

(2010) Thomas Pesnot et al.   Nature Chemical Biology

Selectins promote tumor metastasis

(2010) Heinz Läubli et al.   SEMINARS IN CANCER BIOLOGY

Cancer Cells in Transit: The Vascular Interactions of Tumor Cells

(2009) Konstantinos Konstantopoulos et al.   Annual Review of Biomedical Engineering

Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans

(2009) G. H. Mir et al.   BLOOD

Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes

(2009) H. Laubli et al.   BLOOD

Bisubstrate Analogues as Glycosyltransferase Inhibitors

(2009) Masayuki Izumi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration

(2009) Robert Sackstein   IMMUNOLOGICAL REVIEWS

Glycosylation in immune cell trafficking

(2009) Markus Sperandio et al.   IMMUNOLOGICAL REVIEWS

Lymphocytes in the Peritoneum Home to the Omentum and Are Activated by Resident Dendritic Cells

(2009) D. A. Carlow et al.   JOURNAL OF IMMUNOLOGY

Atomistic Simulation Combined with Analytic Theory To Study the Response of the P-Selectin/PSGL-1 Complex to an External Force

(2009) Kim N. Gunnerson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hybrid Quantum Mechanical/Molecular Mechanical Investigation of the β-1,4-Galactosyltransferase-I Mechanism

(2009) Martin Krupička et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Enzymatic transition states and dynamic motion in barrier crossing

(2009) Steven D Schwartz et al.   Nature Chemical Biology

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Structural insight into mammalian sialyltransferases

(2009) Francesco V Rao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transmission of allostery through the lectin domain in selectin-mediated cell adhesion

(2009) T. T. Waldron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for selectin mechanochemistry

(2009) T. A. Springer   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo

(2009) Christian Ostrau et al.   RADIOTHERAPY AND ONCOLOGY

Synthesis of Glycosyltransferase Inhibitors

(2009) Tetsuya Kajimoto et al.   SYNTHESIS-STUTTGART

Mechanisms for Flow-Enhanced Cell Adhesion

(2008) Cheng Zhu et al.   ANNALS OF BIOMEDICAL ENGINEERING

Catch Bonds in Adhesion

(2008) Wendy Thomas   Annual Review of Biomedical Engineering

Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets

(2008) Laure Bachelet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The selectin–selectin ligand axis in tumor progression

(2008) Isaac P. Witz   CANCER AND METASTASIS REVIEWS

DFT and Docking Study of Potential Transition State Analogue Inhibitors of Glycosyltransferases

(2008) Lucie Sihelniková et al.   COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

Replacing a Lectin Domain Residue in L-selectin Enhances Binding to P-selectin Glycoprotein Ligand-1 but Not to 6-Sulfo-sialyl Lewis x

(2008) Arkadiusz G. Klopocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deoxygenated Disaccharide Analogs as Specific Inhibitors of β1–4-Galactosyltransferase 1 and Selectin-mediated Tumor Metastasis

(2008) Jillian R. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel functions of the CD34 family

(2008) J. S. Nielsen et al.   JOURNAL OF CELL SCIENCE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH

Novel derivatives of UDP-glucose: concise synthesis and fluorescent properties

(2008) Thomas Pesnot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

CD44v4 Is a Major E-Selectin Ligand that Mediates Breast Cancer Cell Transendothelial Migration

(2008) Ke Zen et al.   PLoS One

Two-directional total synthesis of efomycine M and formal total synthesis of elaiolide

(2008) Roland Barth et al.   TETRAHEDRON

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry

Monitoring Receptor-Ligand Interactions between Surfaces by Thermal Fluctuations

(2007) Wei Chen et al.   BIOPHYSICAL JOURNAL