Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing

(2019) Satoshi Uchiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

(2019) Jun Wang et al.   NATURE MEDICINE

Neutrophils escort circulating tumour cells to enable cell cycle progression

(2019) Barbara Maria Szczerba et al.   NATURE

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

(2019) Mark Esposito et al.   NATURE CELL BIOLOGY

Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment

(2019) Quentin Haas et al.   Cancer Immunology Research

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

(2019) H. Angharad Watson et al.   Frontiers in Immunology

Sialic acid blockade suppresses tumor growth by enhancing T cell-mediated tumor immunity

(2018) Christian Büll et al.   CANCER RESEARCH

Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis

(2018) Joana G. Rodrigues et al.   CELLULAR IMMUNOLOGY

β4-Integrin/PI3K Signaling Promotes Tumor Progression through the Galectin-3–N-Glycan Complex

(2018) Yukiko Kariya et al.   MOLECULAR CANCER RESEARCH

Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities

(2018) Emily Rodrigues et al.   Cancers

A Cartography of Siglecs and Sialyltransferases in Gynecologic Malignancies: Is There a Road Towards a Sweet Future?

(2018) Quentin Haas et al.   Frontiers in Oncology

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

(2018) Michal A. Stanczak et al.   JOURNAL OF CLINICAL INVESTIGATION

Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs

(2018) Takashi Angata   Frontiers in Immunology

Targeting sialic acid–Siglec interactions to reverse immune suppression in cancer

(2017) Olivia Joan Adams et al.   GLYCOBIOLOGY

Selectins in cancer immunity

(2017) Lubor Borsig   GLYCOBIOLOGY

Viewing Siglecs through the lens of tumor immunology

(2017) Isabella Fraschilla et al.   IMMUNOLOGICAL REVIEWS

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

(2017) Byron H. Kwan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Roles of Integrin α6β4 Glycosylation in Cancer

(2017) Yoshinobu Kariya et al.   Cancers

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and LeukocytesSignificance

(2016) Norbert Gerdes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monocyte Induction of E-Selectin–Mediated Endothelial Activation Releases VE-Cadherin Junctions to Promote Tumor Cell Extravasation in the Metastasis Cascade

(2016) Irina Häuselmann et al.   CANCER RESEARCH

Glycosylation: a hallmark of cancer?

(2016) Bhairavi N. Vajaria et al.   GLYCOCONJUGATE JOURNAL

CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo

(2016) Gengwen Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of alpha 2,6 sialylation on integrin-mediated adhesion of breast cancer cells to fibronectin and collagen IV

(2016) Ye Yuan et al.   LIFE SCIENCES

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

(2016) Richard Beatson et al.   NATURE IMMUNOLOGY

Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8

(2016) Johannes M. Pröpster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precision glycocalyx editing as a strategy for cancer immunotherapy

(2016) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

(2016) Y. Shamay et al.   Science Translational Medicine

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

(2016) Maurizio Perdicchio et al.   Oncotarget

N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4

(2016) Qinglei Hang et al.   Scientific Reports

Contribution of very late antigen-4 (VLA-4) integrin to cancer progression and metastasis

(2015) Martin Schlesinger et al.   CANCER AND METASTASIS REVIEWS

Sialic acids in cancer biology and immunity

(2015) Oliver M T Pearce et al.   GLYCOBIOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense

(2014) Kayluz Frias Boligan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a Tumor-associated Immunomodulatory Ligand for CD33-related Siglecs

(2014) Heinz Läubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

(2014) Laetitia Seguin et al.   NATURE CELL BIOLOGY

C1GALT1 Promotes Invasive Phenotypes of Hepatocellular Carcinoma Cells by Modulating Integrin β1 Glycosylation and Activity

(2014) Chiung-Hui Liu et al.   PLoS One

Role of Siglec-7 in Apoptosis in Human Platelets

(2014) Kim Anh Nguyen et al.   PLoS One

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

(2014) Heinz Läubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Metastatic Growth Progression Caused by PSGL-1-Mediated Recruitment of Monocytes to Metastatic Sites

(2013) A. Hoos et al.   CANCER RESEARCH

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates

(2013) Vered Padler-Karavani et al.   FASEB JOURNAL

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

Inflammatory chemokines and metastasis—tracing the accessory

(2013) L Borsig et al.   ONCOGENE

PI3K  activates integrin  4 1 to establish a metastatic niche in lymph nodes

(2013) B. Garmy-Susini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

(2012) Monika Julia Wolf et al.   CANCER CELL

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Interactions between endothelial selectins and cancer cells regulate metastasis

(2011) Catherine A. et al.   Frontiers in Bioscience-Landmark

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Transiently Entrapped Circulating Tumor Cells Interact with Neutrophils to Facilitate Lung Metastasis Development

(2010) S. J. Huh et al.   CANCER RESEARCH

Selectins promote tumor metastasis

(2010) Heinz Läubli et al.   SEMINARS IN CANCER BIOLOGY

Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes

(2009) H. Laubli et al.   BLOOD

Extravasation of leukocytes in comparison to tumor cells

(2009) Carina Strell et al.   Cell Communication and Signaling

Deficiencies in the CD40 and CD154 receptor-ligand system reduce experimental lung metastasis

(2009) Susan Blaydes Ingersoll et al.   CLINICAL & EXPERIMENTAL METASTASIS

Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin β4

(2009) T Uemura et al.   ONCOGENE

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA