Review
Oncology
Xinyu Cheng, Huilan Wang, Zhongyu Wang, Bo Zhu, Haixia Long
Summary: Tumor-associated myeloid cells (TAMCs) are crucial immune cell populations in the tumor microenvironment and have a significant impact on immune checkpoint blockade efficacy. Understanding the origin of TAMCs is essential for determining their functional diversity and developing cancer immunotherapy strategies. This review article provides an overview of recent research progress on evaluating the heterogeneity of TAMC origins. It also summarizes major therapeutic strategies targeting TAMCs with diverse sources, shedding light on their implications for cancer immunotherapies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Samantha B. Kemp, Marina Pasca di Magliano, Howard C. Crawford
Summary: Pancreatic ductal adenocarcinoma (PDA) is a nearly universally lethal malignancy characterized by extensive infiltration of immunosuppressive myeloid cells, inhibiting normal immune functions and promoting carcinogenesis. Current immune checkpoint therapy has not been effective in PDA, highlighting the importance of understanding the mechanisms underlying immune suppression in this type of cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Cell Biology
Rodrigo Nalio Ramos, Samuel Campanelli Freitas Couto, Theo Gremen M. Oliveira, Paulo Klinger, Tarcio Teodoro Braga, Eduardo Magalhaes Rego, Jose Alexandre M. Barbuto, Vanderson Rocha
Summary: CAR engineering for T cells and NK cells shows promising results in hematologic cancers but has not proven effective for solid tumors. The scientific community is now looking into mononuclear phagocytes as potential candidates for CAR expression, due to their abilities to overcome barriers posed by solid tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Vijay Kumar, Caitlin Bauer, John H. Stewart
Summary: Myeloid immune cells (MICs) are powerful innate immune responders that recognize altered cellular homeostasis. cGAS/STING signaling plays a critical role in detecting cytosolic dsDNA and activating immune responses. This article explores tumor-supportive changes in the tumor immune microenvironment and discusses the potential of targeting MIC-specific cGAS/STING signaling for tumor immunotherapy.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Tomislav Caval, Frederico Alisson-Silva, Flavio Schwarz
Summary: Cell surface glycosylation plays important roles in cancer, including impaired signaling, metastasis, and evading immune responses. Several glycosyltransferases, such as B3GNT3, FUT8, and B3GNT2, have been linked to reduced anti-tumor immune responses. There is a need for unbiased methods to investigate cell surface glycosylation. The field of glycoproteomics has advanced to allow large-scale profiling of intact glycopeptides for discovering new targets against cancer.
Article
Multidisciplinary Sciences
Benedicte Sjo Tislevoll, Monica Hellesoy, Oda Helen Eck Fagerholt, Stein-Erik Gullaksen, Aashish Srivastava, Even Birkeland, Dimitrios Kleftogiannis, Pilar Ayuda-Duran, Laure Piechaczyk, Dagim Shiferaw Tadele, Jorn Skavland, Baliakas Panagiotis, Randi Hovland, Vibeke Andresen, Ole Morten Seternes, Tor Henrik Anderson Tvedt, Nima Aghaeepour, Sonia Gavasso, Kimmo Porkka, Inge Jonassen, Yngvar Floisand, Jorrit Enserink, Nello Blaser, Bjorn Tore Gjertsen
Summary: In this study, the initial signaling response to standard induction chemotherapy in 32 acute myeloid leukemia (AML) patients was investigated using 36-dimensional mass cytometry. The reduction of extracellular-signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation in the myeloid cell compartment 24 h post-chemotherapy was found to be a significant predictor of patient 5-year overall survival in this cohort. This study demonstrates the value of mass cytometry in early response evaluation in AML and highlights the potential of functional signaling analyses in precision oncology diagnostics.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Giuseppe Bronte, Alberto Verlicchi, Serena De Matteis, Alice Rossi, Alessandra Affatato, Francesco Giulio Sullo, Caterina Gianni, Matteo Canale, Marco Angelo Burgio, Angelo Delmonte, Michele Milella, Lucio Crino
Summary: Immune checkpoint inhibition has shown significant progress in treating non-small cell lung cancer patients, though resistance mechanisms like myeloid-derived suppressor cells and exhausted immune cells may limit effectiveness. Analyzing changes in immune cell subsets and disease progression during treatment could offer insights for developing new targets or biomarkers for cancer immunotherapy resistance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Lucia Sophie Kilian, Derk Frank, Ashraf Yusuf Rangrez
Summary: Cardiomyocytes release cardiocrine signaling molecules that activate immune cells and lead to chronic low-level inflammation, exacerbating a vicious cycle of cardiac inflammation. The small GTPase RhoA plays a key role in stress-mediated cardiomyocyte signal transduction and is considered a potential therapeutic target for immune-cell-mediated inflammatory diseases.
Article
Biochemistry & Molecular Biology
Manami Semba, Shinji Takamatsu, Sachiko Komazawa-Sakon, Eiji Miyoshi, Chiharu Nishiyama, Hiroyasu Nakano, Kenta Moriwaki
Summary: The study identified proscillaridin A as a promising agent that enhances the anti-cancer efficacy of TRAIL therapeutics, particularly in colon cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Lu Cao, Hong Fang, Dong Yan, Xiao Man Wu, Jie Zhang, Ming Xian Chang
Summary: The adhesion molecule CD44 drives host defense in zebrafish by regulating apoptosis and autophagy. CD44a variants mediate antibacterial responses through different mechanisms, with CD44a_tv1 promoting apoptosis and CD44a_tv2 inhibiting autophagy to fight against E. piscicida infection.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sami U. Khan, Ying Xia, David Goodale, Gabriella Schoettle, Alison L. Allan
Summary: The research found that lung-derived selectins can promote the metastatic behavior of TNBC, while selectin knockout can reduce the metastatic progression of TNBC in the lungs. Further studies are aimed at elucidating the pro-metastatic mechanisms of lung-derived selectins and developing a lung-directed therapeutic approach.
Article
Immunology
David Gomez Jimenez, Can Altunbulakli, Sabine Swoboda, Aastha Sobti, David Askmyr, Ashfaq Ali, Lennart Greiff, Malin Lindstedt
Summary: The incidence of HPV+ tonsillar cancer has increased significantly in recent decades. This study used single-cell RNA-sequencing to investigate the myeloid compartment in HPV+ tonsillar cancer. The researchers observed an expansion of the myeloid compartment and interferon-induced cellular responses in dendritic cells and monocyte-macrophages. They discovered four dendritic cell lineages, two macrophage polarization processes, and identified biomarkers that correlate with patient survival. This study contributes to understanding the role of myeloid cells in HPV-driven tonsillar cancer and provides potential prognostic markers.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Laura Barreyro, Avery M. Sampson, Chiharu Ishikawa, Kathleen M. Hueneman, Kwangmin Choi, Mario A. Pujato, Somchai Chutipongtanate, Michael Wyder, Wendy D. Haffey, Eric O'Brien, Mark Wunderlich, Vighnesh Ramesh, Ellen M. Kolb, Cem Meydan, Yaseswini Neelamraju, Lyndsey C. Bolanos, Susanne Christie, Molly A. Smith, Madeline Niederkorn, Tomoya Muto, Santosh Kesari, Francine E. Garrett-Bakelman, Boris Bartholdy, Britta Will, Matthew T. Weirauch, James C. Mulloy, Zartash Gul, Stephen Medlin, Rhett A. Kovall, Ari M. Melnick, John P. Perentesis, Kenneth D. Greis, Elmar Nurmemmedov, William L. Seibel, Daniel T. Starczynowski
Summary: This study found that dysregulation of immune signaling pathways is associated with oncogenic immune signaling states in acute myeloid leukemia (AML) hematopoietic stem and progenitor cells. Inhibition of the ubiquitin-conjugating enzyme UBE2N disrupted oncogenic immune signaling and promoted cell death in AML cells while sparing normal cells. These findings highlight the potential of interfering with UBE2N function as a therapeutic strategy for AML.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Cathrin L. C. Gudd, Lucia A. Possamai
Summary: Cancer treatments that modulate the immune system have been effective, but often result in liver injury. Researchers are studying the mechanisms behind liver inflammation to improve the safety of these treatments.
Article
Immunology
Paola Grazioli, Andrea Orlando, Nike Giordano, Claudia Noce, Giovanna Peruzzi, Behnaz Abdollahzadeh, Isabella Screpanti, Antonio Francesco Campese
Summary: This study reveals that dysregulation of the Notch signaling pathway in T cells promotes the production of MDSCs in a T-ALL mouse model. IL-6 is found to mediate the induction of MDSCs in both mouse and human models.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
L. Knopfova, E. Biglieri, N. Volodko, M. Masarik, M. Hermanova, J. F. Glaus Garzon, M. Ducka, T. Kucirkova, K. Soucek, J. Smarda, P. Benes, L. Borsig
Article
Gastroenterology & Hepatology
Eleonora Cremonesi, Valeria Governa, Jesus Francisco Glaus Garzon, Valentina Mele, Francesca Amicarella, Manuele Giuseppe Muraro, Emanuele Trella, Virginie Galati-Fournier, Daniel Oertli, Silvio Raffael Daster, Raoul A. Droeser, Benjamin Weixler, Martin Bolli, Raffaele Rosso, Ulrich Nitsche, Nina Khanna, Adrian Egli, Simone Keck, Julia Slotta-Huspenina, Luigi M. Terracciano, Paul Zajac, Giulio Cesare Spagnoli, Serenella Eppenberger-Castori, Klaus-Peter Janssen, Lubor Borsig, Giandomenica Iezzi
Article
Multidisciplinary Sciences
Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O'Connor, Quentin Mueller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Gross, Jochen Utikal, Sebastian Haferkamp, Martin R. Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert Hueser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A. Klein, Bernhard Polzer, Lubor Borsig, Mathias Heikenwalder
NATURE COMMUNICATIONS
(2018)
Article
Oncology
Marko Roblek, Darya Protsyuk, Paul F. Becker, Cristina Stefanescu, Christian Gorzelanny, Jesus F. Glaus Garzon, Lucia Knopfova, Mathias Heikenwalder, Bruno Luckow, Stefan W. Schneider, Lubor Borsig
MOLECULAR CANCER RESEARCH
(2019)
Review
Immunology
Heinz Laubli, Lubor Borsig
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Nataliya Volodko, Taras Gutor, Orest Petronchak, Roman Huley, Monika Ducka, Jan Smarda, Lubor Borsig, Petr Benes, Lucia Knopfova
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Christiane F. S. Silva, Juliana M. Motta, Felipe C. O. B. Teixeira, Angelica M. Gomes, Eduardo Vilanova, Eliene O. Kozlowski, Lubor Borsig, Mauro S. G. Pavao
Article
Oncology
Monika Ducka, Martina Kucerikova, Filip Trcka, Jakub Cervinka, Elisabetta Biglieri, Jan Smarda, Lubor Borsig, Petr Benes, Lucia Knopfova
Summary: c-Myb is involved in the activation of genes with protumorigenic function, and its interaction with IL1 alpha and NF-kappa B signaling axis in tumor cells plays a critical role in regulating metastasis and inflammatory genes in breast cancer. This pathway presents a potential target for therapeutic interventions to mimic the antimetastatic effect of c-Myb.
Article
Oncology
Valentina Mele, Camilla Basso, Valeria Governa, Jesus F. Glaus Garzon, Manuele G. Muraro, Silvio Daester, Christian A. Nebiker, Robert Mechera, Martin Bolli, Alexander Schmidt, Roger Geiger, Giulio C. Spagnoli, Dimitri Christoforidis, Pietro E. Majno, Lubor Borsig, Giandomenica Iezzi
Summary: Non-transformed cells of the tumor microenvironment, such as cancer-associated fibroblasts (CAFs) or tumor-associated stromal cells (TASCs), play a role in the growth and prognosis of colon cancer. By comparing the proteome of TASCs derived from colon cancer tissue with that of healthy colon tissue, two novel markers highly associated with poor prognosis were identified.
Article
Multidisciplinary Sciences
Xiaobo Liu, Yuanyuan Wang, Alexander T. Bauer, Michael Kirschfink, Peipei Ding, Christoffer Gebhardt, Lubor Borsig, Thomas Tuting, Thomas Renne, Karsten Haffner, Weiguo Hu, Stefan W. Schneider, Christian Gorzelanny
Summary: The microenvironment of malignant melanomas plays a crucial role in the infiltration and vascular dissemination of immune and cancer cells. In this study, we found that the complement system is activated in melanoma patients and murine melanomas. Complement-derived C5a recruits neutrophils, and activated neutrophils release neutrophil extracellular traps (NETs), which open the endothelial barrier and facilitate the entrance of melanoma cells into circulation. Inhibition of neutrophil activation could prevent vascular intravasation of melanoma cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Merel van Gogh, Jesus F. Glaus Garzon, Dilara Sahin, Lucia Knopfova, Petr Benes, Onur Boyman, Igor Jurisica, Lubor Borsig
Summary: The authors demonstrate that c-Myb expression in tumor cells induces the expression of immune-related genes, leading to immunomodulation and inhibition of tumor growth.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tomas Bertok, Eduard Jane, Nikola Chrenekova, Stefania Hroncekova, Aniko Bertokova, Michal Hires, Alica Vikartovska, Petra Kubanikova, Roman Sokol, Juraj Fillo, Peter Kasak, Lubor Borsig, Jan Tkac
GLYCOCONJUGATE JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Felipe C. O. B. Teixeira, Eliene Oliveira Kozlowski, Kayene Vitoria de A Micheli, Ana Cristina E. S. Vilela-Silva, Lubor Borsig, Mauro S. G. Pavao
Article
Biochemistry & Molecular Biology
Marek W. J. Whitehead, Nikolay Khanzhin, Lubor Borsig, Thierry Hennet
CELL CHEMICAL BIOLOGY
(2017)