Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer
出版年份 2016 全文链接
标题
Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer
作者
关键词
-
出版物
Frontiers in Oncology
Volume 6, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2016-05-13
DOI
10.3389/fonc.2016.00109
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Short O-GalNAc glycans: regulation and role in tumor development and clinical perspectives
- (2016) Joanne Chia et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer
- (2016) Srividya Venkitachalam et al. Scientific Reports
- The Journey from Discoveries in Fundamental Immunology to Cancer Immunotherapy
- (2015) Jacques F.A.P. Miller et al. CANCER CELL
- Galectin-Binding O-Glycosylations as Regulators of Malignancy
- (2015) C. J. Dimitroff CANCER RESEARCH
- The role of active vaccination in cancer immunotherapy: lessons from clinical trials
- (2015) Haydn T Kissick et al. CURRENT OPINION IN IMMUNOLOGY
- Recent developments and future challenges in immune checkpoint inhibitory cancer treatment
- (2015) Bas D. Koster et al. CURRENT OPINION IN ONCOLOGY
- Inflammatory cytokines regulate the expression of glycosyltransferases involved in the biosynthesis of tumor-associated sialylated glycans in pancreatic cancer cell lines
- (2015) Sònia Bassagañas et al. CYTOKINE
- Investigational therapies targeting lymphocyte antigens for the treatment of non-Hodgkin’s lymphoma
- (2015) Michele Merli et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating several cell signaling pathways
- (2015) Yuqin Wang et al. FASEB JOURNAL
- Galectin-1 Regulates Tissue Exit of Specific Dendritic Cell Populations
- (2015) Sandra Thiemann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- G3-C12 Peptide Reverses Galectin-3 from Foe to Friend for Active Targeting Cancer Treatment
- (2015) Wei Sun et al. MOLECULAR PHARMACEUTICS
- Glycan variation and evolution in the eukaryotes
- (2015) Anthony P. Corfield et al. TRENDS IN BIOCHEMICAL SCIENCES
- Pectin in cancer therapy: A review
- (2015) Wenbo Zhang et al. TRENDS IN FOOD SCIENCE & TECHNOLOGY
- Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling
- (2015) Yosuke Harazono et al. Oncotarget
- Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer
- (2015) Andréia Vasconcelos-dos-Santos et al. Frontiers in Oncology
- Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells
- (2015) Yosuke Harazono et al. Oncotarget
- Synthetic Galectin-3 Inhibitor Increases Metastatic Cancer Cell Sensitivity to Taxol-Induced Apoptosis In Vitro and In Vivo
- (2015) Vladislav V. Glinsky et al. NEOPLASIA
- Inhibition of Prostate Cancer Bone Metastasis by Synthetic TF Antigen Mimic/Galectin-3 Inhibitor Lactulose-l-Leucine
- (2015) Olga V. Glinskii et al. NEOPLASIA
- Inhibitors of Galectins and Implications for Structure-Based Design of Galectin-Specific Therapeutics
- (2014) Helen Blanchard et al. AUSTRALIAN JOURNAL OF CHEMISTRY
- Abstract 33: OTX008 pharmacokinetics (PK) during the first-in-man phase I study in patients with advanced solid tumors .
- (2014) Keyvan Rezai et al. CANCER RESEARCH
- Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors
- (2014) Diego O. Croci et al. CELL
- Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense
- (2014) Kayluz Frias Boligan et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor-Infiltrating Lymphocytes
- (2014) N. Demotte et al. CLINICAL CANCER RESEARCH
- OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis
- (2014) Lucile Astorgues-Xerri et al. EUROPEAN JOURNAL OF CANCER
- Galectin-3 inhibitors: a patent review (2008–present)
- (2014) Helen Blanchard et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Galectin-3 inhibition suppresses drug resistance, motility, invasion and angiogenic potential in ovarian cancer
- (2014) Leonardo Mirandola et al. GYNECOLOGIC ONCOLOGY
- Silencing of galectin-3 represses osteosarcoma cell migration and invasion through inhibition of FAK/Src/Lyn activation and β-catenin expression and increases susceptibility to chemotherapeutic agents
- (2014) GA BIN PARK et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance
- (2014) Camilla Jandus et al. JOURNAL OF CLINICAL INVESTIGATION
- Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion
- (2014) S. R. Stowell et al. JOURNAL OF IMMUNOLOGY
- Design and Synthesis of Hydrolytically Stable Multivalent Ligands Bearing Thiodigalactoside Analogues for Peanut Lectin and Human Galectin-3 Binding
- (2014) Alejandro J. Cagnoni et al. JOURNAL OF ORGANIC CHEMISTRY
- Specific Glycosylation of Membrane Proteins in Epithelial Ovarian Cancer Cell Lines: Glycan Structures Reflect Gene Expression and DNA Methylation Status
- (2014) Merrina Anugraham et al. MOLECULAR & CELLULAR PROTEOMICS
- Targeting Prostate Carcinoma by G3-C12 Peptide Conjugated N-(2-Hydroxypropyl)methacrylamide Copolymers
- (2014) Yang Yang et al. MOLECULAR PHARMACEUTICS
- Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
- (2014) Matthew M. Gubin et al. NATURE
- Increased expression ofGCNT1is associated with alteredO-glycosylation of PSA, PAP, and MUC1 in human prostate cancers
- (2014) Zuxiong Chen et al. PROSTATE
- Glycosaminoglycans in cancer treatment
- (2014) Mattias Belting THROMBOSIS RESEARCH
- Altered Tumor-Cell Glycosylation Promotes Metastasis
- (2014) Irina Häuselmann et al. Frontiers in Oncology
- C-4 Modified Sialosides Enhance Binding to Siglec-2 (CD22): Towards Potent Siglec Inhibitors for Immunoglycotherapy
- (2013) Sørge Kelm et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Why anti-Bcl-2 clinical trials fail: a solution
- (2013) Y. Harazono et al. CANCER AND METASTASIS REVIEWS
- Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib
- (2013) Massimo Zucchetti et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Unraveling galectin-1 as a novel therapeutic target for cancer
- (2013) Lucile Astorgues-Xerri et al. CANCER TREATMENT REVIEWS
- Human Galectin-3 Selective and High Affinity Inhibitors. Present State and Future Perspectives
- (2013) R. Tellez-Sanz et al. CURRENT MEDICINAL CHEMISTRY
- Altered Glycosylation in Tumours Focused to Cancer Diagnosis
- (2013) Rosa Peracaula et al. DISEASE MARKERS
- Cell surface protein glycosylation in cancer
- (2013) Maja N. Christiansen et al. PROTEOMICS
- Anti-cancer activities of pH- or heat-modified pectin
- (2013) Lionel Leclere et al. Frontiers in Pharmacology
- Glycosylation of Glycolipids in Cancer: Basis for Development of Novel Therapeutic Approaches
- (2013) Jose L. Daniotti et al. Frontiers in Oncology
- Siglecs and Immune Regulation
- (2012) Shiv Pillai et al. Annual Review of Immunology
- Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment
- (2012) Koichi Ito et al. CANCER AND METASTASIS REVIEWS
- Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease
- (2012) T. Dalotto-Moreno et al. CANCER RESEARCH
- Inhibiting galectin-1 reduces murine lung metastasis with increased CD4+ and CD8+ T cells and reduced cancer cell adherence
- (2012) Koichi Ito et al. CLINICAL & EXPERIMENTAL METASTASIS
- Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide
- (2012) Jessica R. Newton-Northup et al. CLINICAL & EXPERIMENTAL METASTASIS
- GALNT9 Gene Expression Is a Prognostic Marker in Neuroblastoma Patients
- (2012) N. Berois et al. CLINICAL CHEMISTRY
- 5-AZA-2'-deoxycytidine induced demethylation influencesN-glycosylation of secreted glycoproteins in ovarian cancer
- (2012) Radka Saldova et al. Epigenetics
- The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF- secretion from monocytes/macrophages through the DAP12-Syk pathway
- (2012) R. Takamiya et al. GLYCOBIOLOGY
- Carbohydrate-based cancer vaccines: target cancer with sugar bullets
- (2012) Chang-Cheng Liu et al. GLYCOCONJUGATE JOURNAL
- Analysis of the neutral polysaccharide fraction of MCP and its inhibitory activity on galectin-3
- (2012) Xiaoge Gao et al. GLYCOCONJUGATE JOURNAL
- Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
- (2012) Gabriel A. Rabinovich et al. IMMUNITY
- Synergistic and Additive Effects of Modified Citrus Pectin With Two Polybotanical Compounds, in the Suppression of Invasive Behavior of Human Breast and Prostate Cancer Cells
- (2012) Jiahua Jiang et al. INTEGRATIVE CANCER THERAPIES
- Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma
- (2012) Diego O. Croci et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Advances and prospects of anginex as a promising anti-angiogenesis and anti-tumor agent
- (2012) Ju Bo Wang et al. PEPTIDES
- Defining putative glycan cancer biomarkers by MS
- (2012) Yehia Mechref et al. Bioanalysis
- Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress
- (2011) Koichi Ito et al. ANGIOGENESIS
- Treatment of prostate carcinoma with (Galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates
- (2011) Yang Yang et al. BIOMATERIALS
- Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders
- (2011) J. Ouyang et al. BLOOD
- High-Affinity Ligands of Siglec Receptors and their Therapeutic Potentials
- (2011) S. Magesh et al. CURRENT MEDICINAL CHEMISTRY
- A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans
- (2011) Shigeru Tsuboi et al. EMBO JOURNAL
- SIGLEC12, a Human-specific Segregating (Pseudo)gene, Encodes a Signaling Molecule Expressed in Prostate Carcinomas
- (2011) Nivedita Mitra et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins
- (2011) Emma Salomonsson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor Immunity
- (2011) Filiberto Cedeno-Laurent et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin
- (2011) E. O. KOZLOWSKI et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Synthesis of 3-amido-3-deoxy-β-d-talopyranosides: all-cis-substituted pyranosides as lectin inhibitors
- (2011) Christopher T. Öberg et al. TETRAHEDRON
- Synthesis of fluorinated C-mannopeptides as sialyl Lewisx mimics for E- and P-selectin inhibition
- (2010) Vanessa Gouge-Ibert et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The Synergy of 6-O-Sulfation andN- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion
- (2010) Ruifei WANG et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- In vivo targeting of B-cell lymphoma with glycan ligands of CD22
- (2010) W. C. Chen et al. BLOOD
- Tumor Cells Secrete Galectin-1 to Enhance Endothelial Cell Activity
- (2010) V. L. Thijssen et al. CANCER RESEARCH
- A Galectin-3 Ligand Corrects the Impaired Function of Human CD4 and CD8 Tumor-Infiltrating Lymphocytes and Favors Tumor Rejection in Mice
- (2010) N. Demotte et al. CANCER RESEARCH
- Glycomics Hits the Big Time
- (2010) Gerald W. Hart et al. CELL
- PectaSol-C Modified Citrus Pectin Induces Apoptosis and Inhibition of Proliferation in Human and Mouse Androgen-Dependent and- Independent Prostate Cancer Cells
- (2010) Jun Yan et al. INTEGRATIVE CANCER THERAPIES
- Chemically Modified Heparin Inhibits In Vitro L-Selectin-Mediated Human Ovarian Carcinoma Cell Adhesion
- (2010) Zhihong Chen et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Alterations in glycosylation as biomarkers for cancer detection
- (2010) C. A Reis et al. JOURNAL OF CLINICAL PATHOLOGY
- Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response
- (2010) Anna I. Markowska et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Lung Cancer-Derived Galectin-1 Mediates Dendritic Cell Anergy through Inhibitor of DNA Binding 3/IL-10 Signaling Pathway
- (2010) P.-L. Kuo et al. JOURNAL OF IMMUNOLOGY
- Galectins as Cancer Biomarkers
- (2010) Vitaly Balan et al. Cancers
- Using pulse field gradient NMR diffusion measurements to define molecular size distributions in glycan preparations
- (2009) Michelle C. Miller et al. CARBOHYDRATE RESEARCH
- The -galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain
- (2009) M. C Miller et al. GLYCOBIOLOGY
- Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer
- (2009) C.-I. Lin et al. MOLECULAR CANCER RESEARCH
- Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
- (2009) Juan M Ilarregui et al. NATURE IMMUNOLOGY
- Tumor targeting and SPECT imaging properties of an 111In-labeled galectin-3 binding peptide in prostate carcinoma
- (2009) Susan L. Deutscher et al. NUCLEAR MEDICINE AND BIOLOGY
- Proposal for a standard system for drawing structural diagrams ofN- andO-linked carbohydrates and related compounds
- (2009) David J. Harvey et al. PROTEOMICS
- Anti-cancer properties of low-molecular-weight heparin: Preclinical evidence
- (2009) Lars Petersen et al. THROMBOSIS AND HAEMOSTASIS
- Altered Glycosylation of Proteins in Cancer: What Is the Potential for New Anti-Tumour Strategies
- (2008) S. Brooks et al. Anti-Cancer Agents in Medicinal Chemistry
- Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8
- (2008) Christopher T. Öberg et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Double Affinity Amplification of Galectin–Ligand Interactions through Arginine–Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodigalactosides
- (2008) Ian Cumpstey et al. CHEMISTRY-A EUROPEAN JOURNAL
- Restoring the Association of the T Cell Receptor with CD8 Reverses Anergy in Human Tumor-Infiltrating Lymphocytes
- (2008) Nathalie Demotte et al. IMMUNITY
- Expression of UDP-N-acetyl-D-galactosamine: Polypeptide N-acetylgalactosaminyltransferase-6 in Gastric Mucosa, Intestinal Metaplasia, and Gastric Carcinoma
- (2008) Joana Gomes et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Galectin-1 Is a Novel Structural Component and a Major Regulator of H-Ras Nanoclusters
- (2008) Liron Belanis et al. MOLECULAR BIOLOGY OF THE CELL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now