Focus on the Role of NLRP3 Inflammasome in Diseases

Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome

(2020) Ramona D’Amico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus

(2019) Nathanne Santos Ferreira et al.   Cells

NLRP3: A promising therapeutic target for autoimmune diseases

(2018) Hui-Hui Shen et al.   AUTOIMMUNITY REVIEWS

Effects of chronically increased VEGF-A on the aging heart

(2018) Alexander G. Marneros   FASEB JOURNAL

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

(2018) Delphine Gomez et al.   NATURE MEDICINE

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

(2018) Agampodi Promoda Perera et al.   Scientific Reports

NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis

(2018) C Guo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Absence of formyl peptide receptor 1 causes endometriotic lesion regression in a mouse model of surgically-induced endometriosis

(2018) Roberta Fusco et al.   Oncotarget

A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation

(2018) Carolina Pellegrini et al.   Frontiers in Pharmacology

Anakinra Therapy for Non-cancer Inflammatory Diseases

(2018) Giulio Cavalli et al.   Frontiers in Pharmacology

Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy

(2017) Roberta Fusco et al.   FASEB JOURNAL

Regulation of the gut microbiome by inflammasomes

(2017) Grace Y. Chen   FREE RADICAL BIOLOGY AND MEDICINE

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

(2017) Mattia Cocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Zhen Qiu et al.   Oxidative Medicine and Cellular Longevity

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension

(2017) Hai-Jian Sun et al.   Cell Death & Disease

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis

(2017) Xiaomin Yao et al.   Nature Communications

NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy

(2017) Beibei Luo et al.   Frontiers in Physiology

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

(2017) Carolina Pellegrini et al.   Frontiers in Immunology

Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD

(2017) Irene Pierantonelli et al.   Scientific Reports

NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective

(2016) Ø. Sandanger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis

(2016) H Chung et al.   CELL DEATH AND DIFFERENTIATION

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway

(2016) Rojo A Ratsimandresy et al.   Cellular & Molecular Immunology

NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular DamageClinical Perspective

(2016) Thiago Bruder-Nascimento et al.   CIRCULATION

Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse

(2016) Stefano Toldo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans

(2016) Ling Liu et al.   Journal of Crohns & Colitis

HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation

(2016) Manmeet K. Mamik et al.   Journal of Neuroimmune Pharmacology

In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms

(2016) Hazim Kadhim et al.   MEDICAL HYPOTHESES

Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice

(2016) Marius Heitzer et al.   MOLECULAR NEUROBIOLOGY

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a pos

(2015) P. Ruscitti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating Th17 cell differentiation

(2015) Hui Zhang et al.   CLINICAL IMMUNOLOGY

NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins

(2015) Afrasyab Altaf et al.   CORONARY ARTERY DISEASE

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

Drivers of age-related inflammation and strategies for healthspan extension

(2015) Emily L. Goldberg et al.   IMMUNOLOGICAL REVIEWS

Monocyte and M1 Macrophage-induced Barrier Defect Contributes to Chronic Intestinal Inflammation in IBD

(2015) Donata Lissner et al.   INFLAMMATORY BOWEL DISEASES

Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation

(2015) Wenjie Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

InternalizedCryptococcus neoformansActivates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes

(2015) Mingkuan Chen et al.   JOURNAL OF IMMUNOLOGY

The NLRP1 Inflammasome Attenuates Colitis and Colitis-Associated Tumorigenesis

(2015) Tere M. Williams et al.   JOURNAL OF IMMUNOLOGY

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release

(2015) Andreas Hecker et al.   JOURNAL OF IMMUNOLOGY

Role of Genetic Alterations in theNLRP3andCARD8Genes in Health and Disease

(2015) G. V. Paramel et al.   MEDIATORS OF INFLAMMATION

Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis

(2015) E. Peelen et al.   MOLECULAR IMMUNOLOGY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

β-amyloid, microglia, and the inflammasome in Alzheimer’s disease

(2015) Maike Gold et al.   Seminars in Immunopathology

Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis

(2015) Christianna Choulaki et al.   ARTHRITIS RESEARCH & THERAPY

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

(2015) Shuiqing Hu et al.   Cell Reports

Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes

(2015) Mario Nuvolone et al.   PLoS One

Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis

(2014) Yan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages

(2014) Yun Wang et al.   ANNALS OF THE RHEUMATIC DISEASES

NLRP3 and downstream cytokine expression elevated in the monocytes of patients with coronary artery disease

(2014) Lili Wang et al.   Archives of Medical Science

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes

(2014) Sylvie Legrand-Poels et al.   BIOCHEMICAL PHARMACOLOGY

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression

(2014) Willeke M.C. Jong et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis

(2014) Paola Italiani et al.   Journal of Neuroinflammation

Controversies in HIV-associated neurocognitive disorders

(2014) Sam Nightingale et al.   LANCET NEUROLOGY

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation

(2014) Zheng Yin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases

(2014) Gregory R. Robbins et al.   MOLECULAR CELL

Inflammasome activation has an important role in the development of spontaneous colitis

(2014) J Zhang et al.   Mucosal Immunology

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Cardiac Fibroblasts Contribute to Myocardial Dysfunction in Mice with Sepsis: The Role of NLRP3 Inflammasome Activation

(2014) Wenbo Zhang et al.   PLoS One

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

(2014) John G Walsh et al.   Retrovirology

Activation of NLRP3 inflammasome by crystalline structures via cell surface contact

(2014) Aswin Hari et al.   Scientific Reports

The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis

(2014) Aline Dumas et al.   PLoS Pathogens

Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND)

(2014) Vasudev R Rao et al.   AIDS Research and Therapy

Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

(2013) Rebeccah J Mathews et al.   ANNALS OF THE RHEUMATIC DISEASES

Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury

(2013) Y. Zhan et al.   CANCER RESEARCH

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APPswe/PS1dE9 Transgenic Mice via Inhibition of Nuclear Factor-κB and NLRP3 Inflammasome Activation

(2013) Jian-Quan Shi et al.   CNS Neuroscience & Therapeutics

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation

(2013) Weiwei Liu et al.   INFLAMMATION RESEARCH

Obesity development in caspase-1-deficient mice

(2013) H Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Inflammasome induction in Rasmussen’s encephalitis: cortical and associated white matter pathogenesis

(2013) Vijay Ramaswamy et al.   Journal of Neuroinflammation

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Role of caspase-1 in regulation of triglyceride metabolism

(2013) M. E. Kotas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

(2013) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of HMGB1 release by inflammasomes

(2013) Ben Lu et al.   Protein & Cell

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β

(2012) Nathan A. Bracey et al.   EXPERIMENTAL PHYSIOLOGY

Complexity and dynamics of host–fungal interactions

(2012) Fabien Cottier et al.   IMMUNOLOGIC RESEARCH

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease

(2012) Sorina Georgiana Boaru et al.   Journal of Inflammation-London

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

(2012) Fushan Shi et al.   Journal of Neuroinflammation

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-  Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome

(2012) M. Inoue et al.   Science Signaling

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

(2011) Vinay Bhaskar et al.   ATHEROSCLEROSIS

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Misfolded α-synuclein and toll-like receptors: therapeutic targets for Parkinson's disease

(2011) Dawn Béraud et al.   PARKINSONISM & RELATED DISORDERS

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasome in Atherosclerosis and Type 2 Diabetes

(2011) S. L. Masters et al.   Science Translational Medicine

Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver

(2011) Michal Ganz   WORLD JOURNAL OF GASTROENTEROLOGY

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

(2011) P Menu et al.   Cell Death & Disease

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes

(2010) Ben P. Willing et al.   GASTROENTEROLOGY

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

Gene Silencing of NALP3 Protects Against Liver Ischemia–Reperfusion Injury in Mice

(2010) Ping Zhu et al.   HUMAN GENE THERAPY

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

(2010) Simon A. Hirota et al.   INFLAMMATORY BOWEL DISEASES

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

(2010) Rosalba Salcedo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis

(2010) P. J. Shaw et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Blockade of interleukin 1 in type 1 diabetes mellitus

(2010) Thomas Mandrup-Poulsen et al.   Nature Reviews Endocrinology

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

(2010) M. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury

(2010) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice

(2010) Hiroko Tsutsui et al.   Gastroenterology Research and Practice

IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome

(2009) Hong-wei Tan et al.   ATHEROSCLEROSIS

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

(2009) Avlin B. Imaeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Anakinra for Rheumatoid Arthritis: A Systematic Review

(2009) M. MERTENS et al.   JOURNAL OF RHEUMATOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY