Article
Endocrinology & Metabolism
Shanshan Qiao, Chang Liu, Li Sun, Tao Wang, Huanqin Dai, Kai Wang, Li Bao, Hantian Li, Wenzhao Wang, Shuang-Jiang Liu, Hongwei Liu
Summary: This study reveals that a Ganoderma meroterpene derivative can prevent atherosclerosis by increasing the abundance of Parabacteroides merdae in the gut, leading to enhanced branched-chain amino acid catabolism and cardiometabolic benefits.
Article
Immunology
Maria Botia-Sanchez, Georgina Galicia, Lorena Albaladejo-Marico, Daniel Toro-Dominguez, Maria Morell, Raquel Marcos-Fernandez, Abelardo Margolles, Marta E. Alarcon-Riquelme
Summary: Systemic lupus erythematosus is an autoimmune disease that can cause intestinal inflammation, leading to changes in the intestinal barrier and gut microbiota composition, which can in turn affect the interaction between the host immune system and gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Weiling Guo, Bingyong Mao, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Shumao Cui, Hao Zhang
Summary: Lactobacillus paracasei CCFM1223 pretreatment has beneficial effects in preventing lipopolysaccharide-induced acute liver injury and exerts hepatoprotective function through regulating the gut-liver axis.
Article
Nanoscience & Nanotechnology
Yaping Liu, Chengyan Wang, Ruixue Liu, Maoru Zhao, Xuefeng Ding, Tingjun Zhang, Rendong He, Shuang Zhu, Xinghua Dong, Jiani Xie, Zhanjun Gu, Yuliang Zhao
Summary: This study developed a facile but effective oral radioprotector, EGT@HA gel, to protect against radiation gastroenteritis by synergistically regulating oxidative stress, inflammation, and gut microbiota. In vitro and in vivo experiments verified the radioprotective efficacy of EGT@HA by inhibiting reactive oxidative species generation, DNA damage, apoptosis, and gut flora dysbiosis. This work not only advances the development of novel gastrointestinal radioprotectors but also provides a valuable paradigm for gastrointestinal radioprotection by synergistically modulating oxidative stress, inflammation, and gut microbiota disturbance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Kai Wang, Jiahuan Li, Liuwei Zhao, Xiyan Mu, Chen Wang, Miao Wang, Xiaofeng Xue, Suzhen Qi, Liming Wu
Summary: The exposure of polystyrene microplastics has been found to lead to a decrease in gut microbiota diversity, changes in core microbial population structure, and alterations in the expression of key genes in honey bees. The use of tetracycline can significantly increase the toxicity of microplastics.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Microbiology
Yan Zhao, Haoming Sun, Yiwei Chen, Qiang Niu, Yiting Dong, Mei Li, Ye Yuan, Xiaojun Yang, Qingzhu Sun
Summary: This study found a relationship between the reduction of butyrate-producing bacteria and MRSA infection, and supplementation of sodium butyrate has been shown to reduce bacterial colonization and pro-inflammatory cytokine expression, as well as improve lung tissue morphology in MRSA-treated mice. Through reducing the abundance of potential pathogenic bacteria in the gut and cell motility-related bacteria in the lung, sodium butyrate reshapes the gut and lung microbiota. Additionally, sodium butyrate increases the levels of butyrate in the gut and circulation, and alters alveolar macrophage polarization, leading to reduced inflammation.
Article
Immunology
Fei Li, Jiahao Lai, Fei Ma, Yao Cai, Sitao Li, Zhoushan Feng, Zhendong Lu, Xiao Liu, Qiong Ke, Hu Hao, Xin Xiao
Summary: Research indicates that maternal melatonin supplementation can alter the gut microbiota and metabolism of offspring and protect them against LPS-induced inflammation in early life.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Qianqian Ma, Jiaojiao Ma, Jinxiu Cui, Chenxu Zhang, Yuanzhe Li, Juan Liu, Kangning Xie, Erping Luo, Chi Tang, Mingming Zhai
Summary: Acute high-altitude hypoxia can cause intestinal damage and changes in gut microbiota. Oxygen enrichment can protect against intestinal damage caused by acute altitude hypoxia and restore the normal structure and microbiota of the gut.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xingdao Zhang, Yuni Zhang, Yu He, Xingwang Zhu, Qing Ai, Yuan Shi
Summary: The study found that pretreatment with beta-glucan can improve intestinal injury in neonatal mice with necrotizing enterocolitis (NEC). This is achieved by suppressing the TLR4-NF-kappa B signaling pathway, improving intestinal barrier function, and regulating the composition of intestinal microbiota.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Hussein Hamade, Jasmine T. Stamps, Dalton T. Stamps, Shyam K. More, Lisa S. Thomas, Anna Y. Blackwood, Nawele L. Lahcene, Sofi L. Castanon, Brenda C. Salumbides, Yosuke Shimodaira, Helen S. Goodridge, Stephan R. Targan, Kathrin S. Michelsen
Summary: Intestinal dendritic cells play an important role in metabolic syndrome by preserving beneficial microbiota and maintaining intestinal epithelial barrier function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xi Shu, Jing Wang, Liang Zhao, Jian Wang, Pengjie Wang, Feng Zhang, Ran Wang
Summary: This study investigates the preventive effect of Bifidobacterium lactis TY-S01 on alcohol-induced liver injury in mice. The results show that TY-S01 pretreatment effectively protects mice against alcohol-induced liver injury by maintaining the levels of liver enzymes and inflammatory cytokines, preserving the integrity of the intestinal barrier, and preventing gut microbiota dysbiosis. Spearman's correlation analysis reveals a clear correlation among serum indicators, inflammatory cytokines, and gut microbiota. Overall, TY-S01 attenuates alcohol-induced liver injury by preserving intestinal barrier integrity and maintaining gut microbiota balance.
Article
Immunology
Huixiang Yao, Yan Shi, Junqing Yuan, Ri Sa, Wei Chen, Xinjian Wan
Summary: This study demonstrated that matrine attenuated DSS-induced colitis by improving gut barrier integrity, inhibiting the PPAR-alpha signaling pathway, and modulating gut microbiota. These findings suggest that matrine may serve as a therapeutic agent for treating ulcerative colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Shalong Wang, Jingyu Zhou, Da Xiao, Guoshun Shu, Li Gu
Summary: This study demonstrates that bovine lactoferrin (BL) can alleviate colitis in mice by improving the inflammatory response and the structure of the colon barrier. Additionally, BL is able to change the composition and metabolites of the intestinal flora in colitis mice models.
FRONTIERS IN NUTRITION
(2021)
Article
Veterinary Sciences
Min-Jin Kwak, Sun-Woo Choi, Yong-Soon Choi, Hanbae Lee, Kwang-Youn Whang
Summary: This study demonstrates that adding appropriate SPL supplementation in early-weaned piglets can improve growth performance, histological indices, and gene expression levels related to mucin secretion and local inflammation. Furthermore, SPL supplementation increases the population of beneficial bacteria Prevotella and its short-chain fatty acid production, leading to a reduced occurrence of diarrhea in piglets after weaning.
BMC VETERINARY RESEARCH
(2022)
Review
Medicine, Research & Experimental
Jia-Yi Xu, Min-Ting Liu, Tao Tao, Xiao Zhu, Fang-Qin Fei
Summary: The gut microbiota plays a significant role in the occurrence, development, diagnosis, and treatment of tumors, influencing immune regulation and the efficacy of anti-tumor drugs. Understanding how gut microbiota affect tumors can lead to the development of more effective therapies for the disease.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Jingjing Meng, Santanu Banerjee, Dan Li, Gregory M. Sindberg, Fuyuan Wang, Jing Ma, Sabita Roy
SCIENTIFIC REPORTS
(2015)
Article
Immunology
S. Banerjee, G. Sindberg, F. Wang, J. Meng, U. Sharma, L. Zhang, P. Dauer, C. Chen, J. Dalluge, T. Johnson, S. Roy
MUCOSAL IMMUNOLOGY
(2016)
Article
Pathology
Fuyuan Wang, Sabita Roy
TOXICOLOGIC PATHOLOGY
(2017)
Article
Multidisciplinary Sciences
Fuyuan Wang, Jingjing Meng, Li Zhang, Timothy Johnson, Chi Chen, Sabita Roy
SCIENTIFIC REPORTS
(2018)
Article
Pathology
Yanmei Zhang, Fuyuan Wang, Urvashi Bhan, Gary B. Huffnagle, Galen B. Toews, Theodore J. Standiford, Michal A. Olszewski
AMERICAN JOURNAL OF PATHOLOGY
(2010)
Article
Pathology
Xiumiao He, Daniel M. Lyons, Dena L. Toffaletti, Fuyuan Wang, Yafeng Qiu, Michael J. Davis, Daniel L. Meister, Jeremy K. Dayrit, Anthony Lee, John J. Osterholzer, John R. Perfect, Michal A. Olszewski
AMERICAN JOURNAL OF PATHOLOGY
(2012)
Meeting Abstract
Oncology
Maochang Liu, Fuyuan Wang, Michael Shaw, Gabriel Nunez, Grace Yi Chen
Article
Immunology
Grace Y. Chen, Maochang Liu, Fuyuan Wang, John Bertin, Gabriel Nunez
JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Yafeng Qiu, Stuart Zeltzer, Yanmei Zhang, Fuyuan Wang, Gwo-Hsiao Chen, Jeremy Dayrit, Benjamin J. Murdock, Urvashi Bhan, Galen B. Toews, John J. Osterholzer, Theodore J. Standiford, Michal A. Olszewski
JOURNAL OF IMMUNOLOGY
(2012)
Article
Gastroenterology & Hepatology
Fuyuan Wang, Jingjing Meng, Li Zhang, Sabita Roy
Article
Chemistry, Multidisciplinary
Peng Zou, Fuyuan Wang, Jie Wang, Yanhui Lu, Doanh Tran, Shirley K. Seo
Summary: The study found that the absorption of peptides/small proteins is greatly influenced by the injection site, while the absorption of IgGs is influenced by local lymphatic flow and FcRn binding.
JOURNAL OF CONTROLLED RELEASE
(2021)
Meeting Abstract
Neurosciences
Fuyuan Wang, J. Meng, C. Chen, S. Roy
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2015)
Meeting Abstract
Immunology
Santanu Banerjee, Gregory Sindberg, Fuyuan Wang, Umakant Sharma, Timothy Johnson, Sundaram Ramakrishnan, Sabita Roy
JOURNAL OF IMMUNOLOGY
(2014)
Meeting Abstract
Immunology
Jingjing Meng, Dan Li, Sabita Roy, Fuyuan Wang
JOURNAL OF IMMUNOLOGY
(2014)