标题
AIM2 in health and disease: Inflammasome and beyond
作者
关键词
-
出版物
IMMUNOLOGICAL REVIEWS
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2020-07-26
DOI
10.1111/imr.12903
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sjögren's syndrome
- (2020) Aigli G. Vakrakou et al. JOURNAL OF AUTOIMMUNITY
- AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics
- (2020) Miao Qi et al. ONCOGENE
- Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage
- (2020) Bin Yuan et al. Cell Death & Disease
- Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis
- (2020) Thomas P. Burke et al. Nature Microbiology
- Human DNA-PK activates a STING-independent DNA sensing pathway
- (2020) Katelyn Burleigh et al. Science Immunology
- AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment
- (2020) Catherine R. Lammert et al. NATURE
- Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation
- (2020) Chunmei Ma et al. Science Advances
- Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment
- (2019) Qian Yu et al. Cell Death & Disease
- Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome
- (2019) Sara Botto et al. mBio
- AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model
- (2019) Xuyang Wang et al. LIFE SCIENCES
- Inflammasome gene expression is associated with immunopathology in human localized cutaneous leishmaniasis
- (2019) Gaurav Gupta et al. CELLULAR IMMUNOLOGY
- AIM2 promotes non‐small‐cell lung cancer cell growth through inflammasome‐dependent pathway
- (2019) Minda Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Human GBP1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis
- (2019) Daniel Fisch et al. EMBO JOURNAL
- Absent in melanoma 2 inflammasome is required for host defence against Streptococcus pneumoniae infection
- (2019) Siwei Feng et al. Innate Immunity
- Absent in melanoma 2 regulates tumor cell proliferation in glioblastoma multiforme
- (2019) P. A. Chen et al. JOURNAL OF NEURO-ONCOLOGY
- AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice
- (2019) Kristof Johannes Hupa et al. Scientific Reports
- The absent in melanoma 2 (AIM2) inflammasome in microbial infection
- (2019) Wenbo Zhu et al. CLINICA CHIMICA ACTA
- Role of AIM2 inflammasome in inflammatory diseases, cancer and infection
- (2019) Bhesh Raj Sharma et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome
- (2019) Mei‐Juan Zhang et al. FASEB JOURNAL
- Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis
- (2019) Ji Liang et al. EXPERIMENTAL NEUROLOGY
- Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
- (2019) Jian Gao et al. Cell Death & Disease
- AIM2 accelerates the atherosclerotic plaque progressions in ApoE−/− mice
- (2018) Jinyu Pan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury
- (2018) Xintong Ge et al. BRAIN RESEARCH
- Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication
- (2018) Yuhei Maruzuru et al. Cell Host & Microbe
- Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability
- (2018) Nicole Paulin et al. CIRCULATION
- COPs and POPs Patrol Inflammasome Activation
- (2018) Mohanalaxmi Indramohan et al. JOURNAL OF MOLECULAR BIOLOGY
- Emerging Insights into Noncanonical Inflammasome Recognition of Microbes
- (2018) Ashley J. Russo et al. JOURNAL OF MOLECULAR BIOLOGY
- Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD
- (2018) Takanori Komada et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Digital signaling network drives the assembly of the AIM2-ASC inflammasome
- (2018) Mariusz Matyszewski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
- (2018) Ian Gaël Rodrigue-Gervais et al. Scientific Reports
- Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16
- (2018) Pei‐Hui Wang et al. EMBO REPORTS
- Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
- (2018) Ishita Banerjee et al. IMMUNITY
- AIM2 senses Brucella abortus DNA in dendritic cells to induce IL-1β secretion, pyroptosis and resistance to bacterial infection in mice
- (2018) Miriam Maria Silva Costa Franco et al. MICROBES AND INFECTION
- Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity
- (2018) Xiao Yu et al. Nature Communications
- Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection
- (2017) Yutao Wang et al. IMMUNITY
- Alarmins and immunity
- (2017) De Yang et al. IMMUNOLOGICAL REVIEWS
- The AIM2 inflammasome: Sensor of pathogens and cellular perturbations
- (2017) Jérôme Lugrin et al. IMMUNOLOGICAL REVIEWS
- AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality
- (2017) Hongbo Zhang et al. JOURNAL OF IMMUNOLOGY
- AIM2 inflammasome activation and regulation: A structural perspective
- (2017) Bing Wang et al. JOURNAL OF STRUCTURAL BIOLOGY
- Autophagy and inflammasomes
- (2017) James Harris et al. MOLECULAR IMMUNOLOGY
- HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis
- (2017) Shi-Lu Chen et al. Molecular Oncology
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Mitotic progression following DNA damage enables pattern recognition within micronuclei
- (2017) Shane M. Harding et al. NATURE
- Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways
- (2017) Puja Kumari et al. Cell Death & Disease
- The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
- (2017) Rojo A. Ratsimandresy et al. Nature Communications
- Epstein-Barr virus infection-induced inflammasome activation in human monocytes
- (2017) Yuka Torii et al. PLoS One
- AIM2 Inflammasome-Mediated Pyroptosis in Enterovirus A71-Infected Neuronal Cells Restricts Viral Replication
- (2017) Thinesshwary Yogarajah et al. Scientific Reports
- TRIM-directed selective autophagy regulates immune activation
- (2016) Tomonori Kimura et al. Autophagy
- Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation
- (2016) Sivapriya Kailasan Vanaja et al. CELL
- IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes
- (2016) Si Ming Man et al. CELL
- The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway
- (2016) Rojo A Ratsimandresy et al. Cellular & Molecular Immunology
- The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA
- (2016) Elizabeth E. Gray et al. IMMUNITY
- Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens
- (2016) Claudia Zannetti et al. JOURNAL OF IMMUNOLOGY
- Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA
- (2016) Leticia Corrales et al. JOURNAL OF IMMUNOLOGY
- IFN-γ Primes Keratinocytes for HSV-1–Induced Inflammasome Activation
- (2016) Gerhard E. Strittmatter et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection
- (2016) G-Q Hu et al. Mucosal Immunology
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus
- (2016) Andrew J. Monteith et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity
- (2016) Antonia Di Micco et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
- (2016) Bo Hu et al. SCIENCE
- Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway
- (2016) Xiaomin Ma et al. Oncotarget
- TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy
- (2016) Tao Liu et al. Cell Reports
- AIM 2 inflammasomes regulate neuronal morphology and influence anxiety and memory in mice
- (2016) Pei-Jung Wu et al. Scientific Reports
- Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
- (2015) Si Ming Man et al. CELL
- Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection
- (2015) Rajendra Karki et al. Cell Host & Microbe
- AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity
- (2015) Si Ming Man et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease
- (2015) Lucia de Almeida et al. IMMUNITY
- Inhibiting the inflammasome: one domain at a time
- (2015) Andrea Dorfleutner et al. IMMUNOLOGICAL REVIEWS
- Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts
- (2015) Peeraya Ekchariyawat et al. INFECTION GENETICS AND EVOLUTION
- Evasion of inflammasome activation by microbial pathogens
- (2015) Tyler K. Ulland et al. JOURNAL OF CLINICAL INVESTIGATION
- Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2
- (2015) Stefan A. Schattgen et al. JOURNAL OF IMMUNOLOGY
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
- (2015) Si Ming Man et al. NATURE IMMUNOLOGY
- Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida
- (2015) Etienne Meunier et al. NATURE IMMUNOLOGY
- Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt
- (2015) Justin E Wilson et al. NATURE MEDICINE
- Differential expression of inflammasomes in lung cancer cell lines and tissues
- (2015) Hui Kong et al. TUMOR BIOLOGY
- Expression of AIM2 is correlated with increased inflammation in chronic hepatitis B patients
- (2015) Yongtao Han et al. Virology Journal
- Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC
- (2015) Seamus R. Morrone et al. Nature Communications
- The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense
- (2015) Shuiqing Hu et al. Cell Reports
- Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
- (2015) Alvin Lu et al. Cell Discovery
- AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis
- (2015) Christopher Jakobs et al. PLoS One
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
- Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients
- (2014) Susanne Dihlmann et al. INTERNATIONAL JOURNAL OF CANCER
- Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome
- (2014) Stephanie E Adamczak et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions
- (2014) Alvin Lu et al. JOURNAL OF MOLECULAR BIOLOGY
- Critical role for the AIM2 inflammasome during acute CNS bacterial infection
- (2014) Richa Hanamsagar et al. JOURNAL OF NEUROCHEMISTRY
- Inflammatory caspases are innate immune receptors for intracellular LPS
- (2014) Jianjin Shi et al. NATURE
- POP goes the inflammasome
- (2014) Jayendra Kumar Krishnaswamy et al. NATURE IMMUNOLOGY
- The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses
- (2014) Sonal Khare et al. NATURE IMMUNOLOGY
- Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria
- (2014) Parisa Kalantari et al. Cell Reports
- HPV16 activates the AIM2 inflammasome in keratinocytes
- (2013) M. Reinholz et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
- AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
- (2013) V Sagulenko et al. CELL DEATH AND DIFFERENTIATION
- Structural basis for termination of AIM2-mediated signaling by p202
- (2013) Heng Ru et al. CELL RESEARCH
- Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B
- (2013) Dian-Lei Wu et al. HUMAN IMMUNOLOGY
- Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection
- (2013) Eunjoo Park et al. INFECTION AND IMMUNITY
- Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly
- (2013) Tengchuan Jin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Repression of Inflammasome by Francisella tularensis during Early Stages of Infection
- (2013) Rachel J. Dotson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cutting Edge: Mycobacterium tuberculosis but Not Nonvirulent Mycobacteria Inhibits IFN- and AIM2 Inflammasome-Dependent IL-1 Production via Its ESX-1 Secretion System
- (2013) S. Shah et al. JOURNAL OF IMMUNOLOGY
- Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection
- (2013) M. T. R. Gomes et al. JOURNAL OF IMMUNOLOGY
- The AIM2 Inflammasome Is Involved in Macrophage Activation During Infection With Virulent Mycobacterium bovis Strain
- (2013) Yang Yang et al. JOURNAL OF INFECTIOUS DISEASES
- Expression of AIM2 is high and correlated with inflammation in hepatitis B virus associated glomerulonephritis
- (2013) Wenjun Du et al. Journal of Inflammation-London
- AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer
- (2013) Larissa Ponomareva et al. MOLECULAR CANCER RESEARCH
- Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
- (2013) S. R. Morrone et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
- (2013) J. A. Hagar et al. SCIENCE
- Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
- (2013) N. Kayagaki et al. SCIENCE
- Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation
- (2013) Qian Yin et al. Cell Reports
- AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages
- (2012) R Pierini et al. CELL DEATH AND DIFFERENTIATION
- Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma
- (2012) Lih-Chyang Chen et al. EMBO Molecular Medicine
- Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor
- (2012) Tengchuan Jin et al. IMMUNITY
- Critical role of AIM2 in Mycobacterium tuberculosis infection
- (2012) H. Saiga et al. INTERNATIONAL IMMUNOLOGY
- Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
- (2012) Rebecca L. Brunette et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking
- (2012) J. Ge et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis
- (2011) Kaitian Peng et al. CELLULAR MICROBIOLOGY
- Immune Signaling by RIG-I-like Receptors
- (2011) Yueh-Ming Loo et al. IMMUNITY
- Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to Streptococcus pneumoniae Infection
- (2011) R. Fang et al. JOURNAL OF IMMUNOLOGY
- Autophagy in immunity and inflammation
- (2011) Beth Levine et al. NATURE
- Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions
- (2011) Y. Dombrowski et al. Science Translational Medicine
- Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol
- (2010) John-Demian Sauer et al. Cell Host & Microbe
- Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility Locus
- (2010) R. Panchanathan et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Mutation of Francisella tularensis mviN Leads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and a Loss of Virulence
- (2010) T. K. Ulland et al. JOURNAL OF IMMUNOLOGY
- Deletion of ripA Alleviates Suppression of the Inflammasome and MAPK by Francisella tularensis
- (2010) M. T.-H. Huang et al. JOURNAL OF IMMUNOLOGY
- Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
- (2010) M. Lamkanfi et al. JOURNAL OF IMMUNOLOGY
- The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
- (2010) Vijay A K Rathinam et al. NATURE IMMUNOLOGY
- The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
- (2010) Teresa Fernandes-Alnemri et al. NATURE IMMUNOLOGY
- Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
- (2010) J. W. Jones et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
- (2009) Teresa Fernandes-Alnemri et al. NATURE
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
- (2009) Veit Hornung et al. NATURE
- An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
- (2009) Tilmann Bürckstümmer et al. NATURE IMMUNOLOGY
- HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
- (2009) T. L. Roberts et al. SCIENCE
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