Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens

Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β

(2016) Ghulam Ilyas et al.   JOURNAL OF HEPATOLOGY

The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity

(2015) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice

(2015) Arvin Iracheta-Vellve et al.   JOURNAL OF HEPATOLOGY

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

(2015) Etienne Meunier et al.   NATURE IMMUNOLOGY

Expression of AIM2 is correlated with increased inflammation in chronic hepatitis B patients

(2015) Yongtao Han et al.   Virology Journal

The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis

(2015) Sheng Guo et al.   PLoS Pathogens

Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function

(2014) M. G. Ghonime et al.   JOURNAL OF IMMUNOLOGY

Kupffer Cells Interact With Hepatitis B Surface Antigen In Vivo and In Vitro, Leading to Proinflammatory Cytokine Production and Natural Killer Cell Function

(2014) Arjan Boltjes et al.   JOURNAL OF INFECTIOUS DISEASES

Downregulation of Interleukin-18-Mediated Cell Signaling and Interferon Gamma Expression by the Hepatitis B Virus e Antigen

(2014) S. Jegaskanda et al.   JOURNAL OF VIROLOGY

Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver

(2014) Juandy Jo et al.   PLoS Pathogens

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Interleukin-1 and Tumor Necrosis Factor-α Trigger Restriction of Hepatitis B Virus Infection via a Cytidine Deaminase Activation-induced Cytidine Deaminase (AID)

(2013) Koichi Watashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct development and functions of resident and recruited liver Kupffer cells/macrophages

(2013) Masami Ikarashi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner

(2012) Magali Perret et al.   CELLULAR MICROBIOLOGY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-β1 over pro-inflammatory cytokines

(2011) Hai Li et al.   DIGESTIVE AND LIVER DISEASE

Francisella tularensisReveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation

(2011) Maninjay K. Atianand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C virus activates interleukin-1  via caspase-1-inflammasome complex

(2011) D. Burdette et al.   JOURNAL OF GENERAL VIROLOGY

The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway

(2011) Tali Lang et al.   JOURNAL OF HEPATOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells

(2011) Isabelle E. Vincent et al.   PLoS One

Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-β induction by disrupting the VISA-associated complex

(2010) Xianmiao Wang et al.   Cellular & Molecular Immunology

C/EBPδ and STAT-1 Are Required forTLR8Transcriptional Activity

(2010) Claudia Zannetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon

(2010) M. Kumar et al.   JOURNAL OF VIROLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

(2009) Marianna Hösel et al.   HEPATOLOGY

HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells

(2009) Yongfen Xu et al.   MOLECULAR IMMUNOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

(2009) Julie Delaloye et al.   PLoS Pathogens

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Hepatitis B Virus Infection

(2008) Jules L. Dienstag   NEW ENGLAND JOURNAL OF MEDICINE