Article
Multidisciplinary Sciences
Xiaolin Zhang, Qingping Lan, Mingyu Zhang, Fan Wang, Keyi Shi, Xiaojuan Li, Ersheng Kuang
Summary: Inflammasomes are important innate immune defenses against viral and bacterial infections. Various inflammasome sensors can detect invading pathogens and trigger inflammasome activation and/or pyroptosis in infected cells. Kaposi's sarcoma-associated herpesvirus (KSHV) employs a protein called SOX to suppress AIM2 inflammasome activation, promoting viral replication and inhibiting pyroptosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Virology
Hannah L. Wallace, Rodney S. Russell
Summary: It is well-known that viruses can activate various inflammasomes, leading to programmed cell death and release of inflammatory cytokines. Traditionally, RNA viruses were thought to activate NLRP3 inflammasomes, while DNA viruses activate AIM2 inflammasomes. However, recent research suggests that viruses can activate multiple inflammasome sensors simultaneously.
Article
Chemistry, Medicinal
Yan Jiao, Jinshan Nan, Bo Mu, Yun Zhang, Nenghua Zhou, Shunhua Yang, Shanshan Zhang, Wanting Lin, Falu Wang, Anjie Xia, Zhixing Cao, Pei Chen, Zhiling Pan, Guifeng Lin, Shulei Pan, Huachao Bin, Linli Li, Shengyong Yang
Summary: By screening against NLRP3-dependent pyroptosis, a novel compound J114 was discovered, which displayed significant inhibitory activity against human cell pyroptosis and showed distinct differences from existing pyroptosis inhibitors. Further studies revealed that J114 inhibited inflammasome activation by disrupting the interaction between NLRP3 or AIM2 and the adaptor protein ASC.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Bangzuo Ning, Jingjing Shen, Fanglin Liu, Hemin Zhang, Xin Jiang
Summary: Current strategies for treating drug-resistant tuberculosis are limited in effectiveness and have undesirable side effects. Therefore, research on new treatments, including innovative medications, is required. Host-directed therapy (HDT) has emerged as a viable strategy for enhancing protective immunity against infections. In this study, baicalein, derived from Scutellariae radix, was found to inhibit pyroptosis in Mycobacterium tuberculosis-infected macrophages and promote autophagy, suggesting its potential as a new adjunctive HDT drug.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Zhi Huan Chew, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Tan, Shreya Kar, Kai Kiat Koh, Kritika Singh, Hong Meng Lim, Soo Chin Lee, Alan Prem Kumar, Stephan Gasser, Lina H. K. Lim
Summary: Intracellular recognition of tumor-derived nucleic acids can activate macrophages, leading to inflammasome activation in the tumor microenvironment, which initiates pro-inflammatory and anti-tumorigenic responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Carmen De Miguel, Pablo Pelegrin, Alberto Baroja-Mazo, Santiago Cuevas
Summary: Inflammasomes and pyroptosis play crucial roles in the development of hypertension, with pharmacological inhibition of inflammasomes leading to reduced blood pressure. This pathway shows potential as a future anti-hypertensive strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Mei-Zi Wang, Jie Wang, Dong-Wei Cao, Yue Tu, Bu-Hui Liu, Can-Can Yuan, Huan Li, Qi-Jun Fang, Jia-Xin Chen, Yan Fu, Bing-Ying Wan, Zi-Yue Wan, Yi-Gang Wan, Guo-Wen Wu
Summary: The study confirmed that FPS, similar to RAP, can alleviate RF in DKD by inhibiting NLRP3 inflammasome-mediated podocyte pyroptosis, regulating the AMPK/mTORC1/NLRP3 signaling axis. These findings provide an in-depth understanding of the pathogenesis of RF, aiding in identifying precise targets for DKD treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhen Li, Zehui Li, Zhenyue Chen, He Sun, Zhagen Yuan, Xiaochao Wang, Jinqiang Wei, Xuewei Cao, Decai Zheng
Summary: Andro has shown neuroprotective effects against spinal cord injury (SCI) by reducing apoptosis, oxidative stress, and inflammation, promoting axonal regeneration and remyelination, leading to tissue repair and functional recovery.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Ting-Ting Chen, Feng Xiao, Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei, Wu-Yi Sun
Summary: Fibrosis, the final stage of chronic inflammation, remains poorly understood in terms of its molecular mechanisms. The inflammasome, a protein complex key to host immunity, has been found to play a crucial role in regulating cytokine responses and potentially serving as novel targets for antifibrotic therapies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Toshihiko Aki, Kana Unuma, Koichi Uemura
Summary: Oxidative stress is a key factor in the pathogenesis of immune disorders. Prdxs play important roles in maintaining cellular redox homeostasis, regulating signal transduction, and activating the immune response. This review provides an overview of the roles of Prdxs in inflammatory disorders.
Article
Cell Biology
Guoxing You, Linbo Zheng, Yuanyuan Zhang, Yuting Zhang, Yupeng Wang, Wenjie Guo, Hao Liu, Philipovich Tatiana, Kulchitsky Vladimir, Jie Zan
Summary: This study investigated the protective mechanism of TANG against cerebral ischemia/reperfusion (I/R) injury. The results showed that TANG could alleviate brain injury and inhibit neuronal pyroptosis induced by I/R both in vivo and in vitro. Furthermore, TANG inhibited the activation of neuronal AIM2 inflammasome via regulating NRF2. Therefore, TANG may be a potential therapeutic agent for cerebral I/R injury.
Review
Immunology
Baolong Li, Jin Guo, Xiongyao Zhou, Weizhen Li, Ningning Wang, Rangjuan Cao, Shusen Cui
Summary: Neuropathic pain caused by somatosensory system injuries is challenging to treat. There is evidence suggesting that neuroinflammation and cell death play a role in the development of neuropathic pain. Pyroptosis, a form of programmed cell death related to inflammation, has the potential to enhance or sustain the inflammatory response. This review provides an overview of pyroptosis and its mechanisms, discussing its relevance in neuropathic pain and its therapeutic potential as a target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Guo Mu, Qiang Li, Bin Lu, Xuan Yu
Summary: Trigeminal neuralgia (TN) is a complex orofacial neuropathic pain characterized by lightning-like pain. Chronic inflammation and nerve demyelination play a major role in TN. In this study, the intra-intestinal application of a hydrogen-producing Si-based agent demonstrated a reduction in inflammation and neural demyelination in TN rats. Additionally, the mechanism behind the neural effects of the Si-based agent involves the inhibition of microglial pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xinyu Xu, Huanhuan Fan, Ying Yang, Shankun Yao, Wenhao Yu, Zijian Guo, Weihong Tan
Summary: By self-assembling virus-like particles with long DNA building blocks generated through rolling-circle amplification and covered with cationic liposomes, cGAS liquid phase condensation and STING signaling activation can be efficiently induced, leading to the production of inflammatory cytokines and boosting antitumor immunity. Additionally, these virus-like particles can also trigger the formation of AIM2 inflammasome and induce gasdermin D-mediated pyroptosis, further enhancing antitumor immunity. Thus, this study provides a simple and robust strategy for cancer immunotherapy for clinical application.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Valeria Di Battista, Maria Teresa Bochicchio, Giulio Giordano, Mariasanta Napolitano, Alessandro Lucchesi
Summary: The past decade has seen significant advancements in the understanding of chronic myeloproliferative neoplasms through preclinical research. The translational implications of these new biological discoveries inform future therapeutic strategies, with a focus on the role of inflammasomes in guiding and impacting the disease's natural history. Greater knowledge in this area has the potential to lead to improved care for patients with MPNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jian Gao, Zhigui Wu, Mingxia Zhao, Rui Zhang, Manru Li, Dongdong Sun, Haibo Cheng, Xianjia Qi, Yuxian Shen, Qiang Xu, Hongqi Chen, Dijun Chen, Yang Sun
Summary: This study reveals the role of SHP2 in innate immunosuppression in the tumor microenvironment. Inhibition of SHP2 can effectively arrest the malignant evolution of tumor cells and activate the interferon signaling pathway in infiltrated myeloid cells. The findings also suggest a potential role of macrophagic SHP2 in colon cancer immunotherapy, especially in patients with MSS phenotype.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Medicine, Research & Experimental
Yuyu Zhu, Zhigui Wu, Wei Yan, Fenli Shao, Bowen Ke, Xian Jiang, Jian Gao, Wenjie Guo, Yuping Lai, Hongyue Ma, Dijun Chen, Qiang Xu, Yang Sun
Summary: The study identified SHP2 as a novel regulator of psoriasis, showing that SHP2 inhibition can reduce skin inflammation and may be a promising therapeutic approach for psoriatic patients.
EMBO MOLECULAR MEDICINE
(2022)
Article
Rheumatology
Qianqian Liu, Linhui Zhai, Mingrui Han, Dongquan Shi, Ziying Sun, Shuang Peng, Meijing Wang, Chenyang Zhang, Jian Gao, Wenjin Yan, Qing Jiang, Dijun Chen, Qiang Xu, Minjia Tan, Yang Sun
Summary: In this study, the researchers identified SHP-2 as a novel regulator of cartilage homeostasis in osteoarthritis (OA). Inhibition of SHP-2 improved OA progression by maintaining the balance of cartilage metabolism.
ARTHRITIS & RHEUMATOLOGY
(2022)
Review
Immunology
Darko Stojkov, Lea Gigon, Shuang Peng, Robert Lukowski, Peter Ruth, Alexander Karaulov, Albert Rizvanov, Nickolai A. Barlev, Shida Yousefi, Hans-Uwe Simon
Summary: Neutrophils, the most abundant cells in the leukocyte population, can modulate glycolysis and other metabolic pathways to limit their effector functions. These metabolic pathways are crucial for energy usage and specialized actions, such as ROS production, chemotaxis, phagocytosis, degranulation, and the formation of NETs. Understanding the requirements of metabolic pathways for neutrophil functions may lead to the discovery of molecular targets for novel anti-infectious and/or anti-inflammatory drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Jiangshan Bai, Michael J. Song, Jian Gao, Guiting Li
Summary: PINOID is a kinase belonging to the AGCVIII family, which regulates the polar distribution of PIN proteins and plays an important role in plant geotropism. This study identified 79 similar sequences across 17 plant species genomes and investigated the evolution of PINOID kinases from a phylogenetic perspective. The results suggest that the AGCVIII kinase family may have originated from related Hypothetical Kinases and differentiated their functions in different plant classes.
Article
Pharmacology & Pharmacy
Minmin Fan, Jian Gao, Lin Zhou, Wenwen Xue, Yixuan Wang, Jingwei Chen, Wuhao Li, Ying Yu, Bo Liu, Yan Shen, Qiang Xu
Summary: The expression of SERCA2 in triple negative breast cancer (TNBC) patients is closely related to disease progression, and it also promotes the growth, migration and chemoresistance of breast cancer cells. Through experiments, it is proven that SERCA2 can interact with LC3B, induce cell autophagy, and increase the tolerance of breast cancer cells to drugs. In addition, it is found that targeting SERCA2 can increase cell autophagy and induce cell death, achieving the therapeutic effect of treating breast cancer.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Yixuan Wang, Jian Gao, Ying Yu, Lin Zhou, Miao Wang, Wenwen Xue, Bo Liu, Xudong Wu, Xuefeng Wu, Huiyuan Gao, Yan Shen, Qiang Xu
Summary: Research has shown that CA-e is a selective glucocorticoid receptor modulator that can attenuate the side effects of glucocorticoid therapy and alleviate inflammation in multiple mouse models.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Ahmed Elgehama, Yixuan Wang, Ying Yu, Lin Zhou, Zhixiu Chen, Liwei Wang, Lijun Sun, Jian Gao, Biao Yu, Yan Shen, Qiang Xu
Summary: This study unravels the action mechanism of PTP1B in stabilizing Bcr-Abl1 protein and indicates that the PTP1B-Bcr-Abl1 interaction might be one of druggable targets for TKI-resistant CML with point mutations.
Article
Immunology
Longbo Yu, Yuanyuan Wang, Yingxue He, Haiqing Zhong, Shushan Ge, Yi Zou, Yisheng Lai, Qiang Xu, Jian Gao, Wen Liu, Wenjie Guo
Summary: The combination of apo-IDO1 inhibitor and apatinib showed significant inhibition of colorectal cancer growth, increased apoptosis of cancer cells, and reprogrammed the immune microenvironment to enhance immune killing ability.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuang Peng, Darko Stojkov, Jian Gao, Kevin Oberson, Philipp Latzin, Carmen Casaulta, Shida Yousefi, Hans-Uwe Simon
Summary: This study reveals a previously unknown role of RHOH in regulating actomyosin-mediated neutrophil effector functions. RHOH, constitutively GTP-bound, limits neutrophil degranulation and the formation of neutrophil extracellular traps. RHOH achieves this by inhibiting the transport of mitochondria and granules along actin filaments, and by modulating actin polymerization through RAC1 activity. In vivo studies using Rhoh(-/-) mice demonstrate an increased antibacterial defense capability against Escherichia coli.
Review
Immunology
Shuang Peng, Jian Gao, Darko Stojkov, Shida Yousefi, Hans-Uwe Simon
Summary: Neutrophils, the most abundant innate immune cells in human blood, have been overlooked in terms of their mitochondria function. However, growing evidence shows that mitochondria play a crucial role in various aspects of neutrophil biology, from development to chemotaxis, effector function, and cell death. Mitochondria and their components can also be released by neutrophils to eliminate infection and shape immune response. This review highlights the importance of mitochondria in modulating neutrophil phenotype and function during infection and inflammation, and discusses the potential and challenges of exploiting mitochondria in neutrophils for disease treatment.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Wenwen Xue, Xin Li, Wuhao Li, Yixuan Wang, Chengfei Jiang, Lin Zhou, Jian Gao, Ying Yu, Yan Shen, Qiang Xu
Summary: CYTL1 is identified as a novel tumor suppressor that inhibits the robust glycolytic switching in breast cancer cells, leading to the attenuation of cell growth and metastasis. Its mechanism involves competitive binding with NDUFV1 to stabilize the protein and interaction with Src to reduce lactate production.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)