Autophagy: a promising process for the treatment of acetaminophen-induced liver injury

NBR 1‐mediated p62‐liquid droplets enhance the Keap1‐Nrf2 system

(2020) Pablo Sánchez‐Martín et al.   EMBO REPORTS

ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

(2020) Haruka Chino et al.   TRENDS IN CELL BIOLOGY

The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates

(2020) Soyoung Park et al.   Nature Communications

Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy

(2019) Tao Zhou et al.   Redox Biology

Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis

(2019) Ning-Ping Zhang et al.   LABORATORY INVESTIGATION

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Endoplasmic reticulum stress‐dependent autophagy inhibits glycated high‐density lipoprotein‐induced macrophage apoptosis by inhibiting CHOP pathway

(2019) Hua Tian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease

(2019) Zhou Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

(2019) Lorena Fernandez-Mosquera et al.   Autophagy

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

Bacterial outer membrane vesicles trigger pre-activation of a xenophagic response via AMPK

(2019) Truc T. Losier et al.   Autophagy

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

(2019) Man J. Livingston et al.   Autophagy

Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

(2019) Leo J Dudley et al.   EMBO JOURNAL

Endoplasmic Reticulum Stress-induced Upregulation of STARD1 Promotes Acetaminophen-induced Acute Liver Failure

(2019) Sandra Torres et al.   GASTROENTEROLOGY

Dual Roles of mTOR in Regulating Liver Injury and Tumorigenesis in Autophagy Defective Mouse Liver

(2019) Hong‐Min Ni et al.   HEPATOLOGY

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

(2019) Hua Wang et al.   Redox Biology

In Situ Manipulation of Dendritic Cells by an Autophagy-Regulative Nanoactivator Enables Effective Cancer Immunotherapy

(2019) Yi Wang et al.   ACS Nano

Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development

(2019) Rei Unno et al.   Autophagy

Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43

(2019) Aneesh Donde et al.   Autophagy

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation

(2019) Ying He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decelerating ageing and biological clocks by autophagy

(2019) Carlos Lopez-Otín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice

(2019) Ying Zhou et al.   HEPATOLOGY

Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3 inflammasome activation

(2019) Shulin Shan et al.   BIOCHEMICAL PHARMACOLOGY

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition

(2019) Longjun Li et al.   CELL DEATH AND DIFFERENTIATION

Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases

(2019) Qi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality

(2018) Daniel R. Ganger et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease

(2018) Stefan W. Ryter et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and acetaminophen-induced hepatotoxicity

(2018) Shulin Shan et al.   ARCHIVES OF TOXICOLOGY

NLRP3: A promising therapeutic target for autoimmune diseases

(2018) Hui-Hui Shen et al.   AUTOIMMUNITY REVIEWS

Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation

(2018) Penghao Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy

(2018) Mingzhu Yan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

Knockout of ULK1/2 protects against acetaminophen-induced acute liver injury independent of autophagy?

(2018) Cuiqin Zhang et al.   HEPATOLOGY

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

(2018) Anke Di et al.   IMMUNITY

Mst1 promotes cardiac ischemia–reperfusion injury by inhibiting the ERK-CREB pathway and repressing FUNDC1-mediated mitophagy

(2018) Wancheng Yu et al.   Journal of Physiological Sciences

Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis

(2018) Miao Li et al.   JOURNAL OF VIROLOGY

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

(2018) Charles S. Dela Cruz et al.   MITOCHONDRION

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypothalamic endoplasmic reticulum stress as a key mediator of obesity-induced leptin resistance

(2018) Z. Ye et al.   Obesity Reviews

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

(2018) Anna Moles et al.   Frontiers in Pharmacology

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

(2018) Mingzhu Yan et al.   Redox Biology

To save or degrade: balancing proteasome homeostasis to maximize cell survival

(2018) Richard S. Marshall et al.   Autophagy

FUNDC1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation

(2018) Wenhui Li et al.   HEPATOLOGY

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

(2018) Saikat Chowdhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation

(2018) Tetsuya Kotani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Augmenter of Liver Regeneration Protects Against Acetaminophen-Induced Acute Liver Injury in Mice by Promoting Autophagy

(2018) Ting Hu et al.   SHOCK

Enhanced autophagy contributes to protective effects of IL-22 against acetaminophen-induced liver injury

(2018) Ruidong Mo et al.   Theranostics

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

(2018) Sandra M. Hill et al.   CELL DEATH AND DIFFERENTIATION

Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux

(2018) Ki-Young Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Alarmins and immunity

(2017) De Yang et al.   IMMUNOLOGICAL REVIEWS

Autophagy-regulating protease Atg4: structure, function, regulation and inhibition

(2017) Tatsuro Maruyama et al.   JOURNAL OF ANTIBIOTICS

Early Stage Functions of Mitochondrial Autophagy and Oxidative Stress in Acetaminophen-Induced Liver Injury

(2017) Yan Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?

(2017) William M. Lee   JOURNAL OF HEPATOLOGY

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

(2017) Daniela Bakula et al.   Nature Communications

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

(2017) Lucía Barbier-Torres et al.   Nature Communications

Modulating Mitophagy in Mitochondrial Disease

(2017) Eszter Dombi et al.   CURRENT MEDICINAL CHEMISTRY

Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice

(2016) Jihye Han et al.   Autophagy

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Cysteine residues mediate high-affinity binding of thioredoxin to ASK1

(2016) Salome Kylarova et al.   FEBS Journal

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

Retinoic Acid Induced-Autophagic Flux Inhibits ER-Stress Dependent Apoptosis and Prevents Disruption of Blood-Spinal Cord Barrier after Spinal Cord Injury

(2016) Yulong Zhou et al.   International Journal of Biological Sciences

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β

(2016) Ghulam Ilyas et al.   JOURNAL OF HEPATOLOGY

AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function

(2016) Sun Woo Sophie Kang et al.   PLoS One

Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy

(2016) Mengqi Lv et al.   Protein & Cell

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

(2016) Kuo Du et al.   Redox Biology

Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice

(2015) Anup Ramachandran et al.   ARCHIVES OF TOXICOLOGY

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes

(2015) Sudip Banerjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice

(2015) Jessica A. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Pink1-Parkin-mediated mitophagy for treating liver injury

(2015) Jessica A. Williams et al.   PHARMACOLOGICAL RESEARCH

Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury

(2015) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

WIPI2b and Atg16L1: setting the stage for autophagosome formation

(2014) Michael I. Wilson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular Mechanism of Autophagic Membrane-Scaffold Assembly and Disassembly

(2014) Anna Kaufmann et al.   CELL

Acetaminophen Reactive Intermediates Target Hepatic Thioredoxin Reductase

(2014) Yi-Hua Jan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice

(2014) Pedro Elias Marques et al.   HEPATOLOGY

Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice

(2014) Zhuofeng Lin et al.   JOURNAL OF HEPATOLOGY

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy

(2014) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

(2014) Venkata Prasuja Nakka et al.   MOLECULAR NEUROBIOLOGY

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

(2014) Daniel J Klionsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Application of Interleukin-22 Mediates Protection in Experimental Acetaminophen-Induced Acute Liver Injury

(2013) Patrick Scheiermann et al.   AMERICAN JOURNAL OF PATHOLOGY

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

(2013) Dotan Uzi et al.   JOURNAL OF HEPATOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

(2012) Lyndsay Murrow et al.   Annual Review of Pathology-Mechanisms of Disease

Targeting autophagy for drug-induced hepatotoxicity

(2012) Hong-Min Ni et al.   Autophagy

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

(2012) Hong-Min Ni et al.   TOXICOLOGICAL SCIENCES

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice

(2011) Aditya Ambade et al.   HEPATOLOGY

Cellular Iron Depletion Stimulates the JNK and p38 MAPK Signaling Transduction Pathways, Dissociation of ASK1-Thioredoxin, and Activation of ASK1

(2011) Yu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Autophagy in liver diseases

(2010) Pierre-Emmanuel Rautou et al.   JOURNAL OF HEPATOLOGY

Acute liver failure

(2010) William Bernal et al.   LANCET

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Atg8 Controls Phagophore Expansion during Autophagosome Formation

(2008) Zhiping Xie et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE