IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

(2013) Arik Cooper et al.   NATURE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein

(2012) S Bobadilla et al.   GENE THERAPY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

(2012) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

(2012) Benjamin Descours et al.   Retrovirology

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

(2012) Grazia Rosaria Gariano et al.   PLoS Pathogens

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1–derived lentiviral vectors

(2011) Grégory Berger et al.   Nature Protocols

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

(2010) Gilad Doitsh et al.   CELL

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

The CXCR4-Tropic Human Immunodeficiency Virus Envelope Promotes More-Efficient Gene Delivery to Resting CD4+ T Cells than the Vesicular Stomatitis Virus Glycoprotein G Envelope

(2009) L. M. Agosto et al.   JOURNAL OF VIROLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

The HIV Envelope but Not VSV Glycoprotein Is Capable of Mediating HIV Latent Infection of Resting CD4 T Cells

(2009) Dongyang Yu et al.   PLoS Pathogens

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

(2008) A. Bosque et al.   BLOOD

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE