Article
Biochemistry & Molecular Biology
Benoit J. Pons, Aurelie Pettes-Duler, Claire Naylies, Frederic Taieb, Catherine Bouchenot, Saleha Hashim, Patrick Rouimi, Maxime Deslande, Yannick Lippi, Gladys Mirey, Julien Vignard
Summary: The bacterial genotoxin CDT activates the DNA Damage Response and enhances the host immune response by promoting a strong type I interferon (IFN) response. The effects of CDT on cell cycle regulation, DNA damage, and immune response may vary depending on cell and tissue type.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Na-Lee Ka, Ga Young Lim, Sewon Hwang, Seung-Su Kim, Mi-Ock Lee
Summary: The role of IFI16 in DNA repair enhances STING-type-I IFN signaling, offering potential therapeutic strategies for triple-negative breast cancer patients.
Article
Microbiology
Le Liang, Yujuan Shen, Yuan Hu, Haipeng Liu, Jianping Cao
Summary: In this study, the impact of Cgas and Sting protein deficiencies on mice infected with S. japonicum was investigated, providing new insights into potential treatments for liver pathology associated with schistosomiasis.
Article
Cell Biology
Hyoungnae Kim, Mi Ra Yu, Haekyung Lee, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, Hyunjin Noh
Summary: Research has shown that MSCs from patients with CKD exhibit reduced proliferation, accelerated senescence, and increased DNA damage compared to healthy MSCs, but these changes were significantly reduced after metformin treatment. Metformin enhances the paracrine action of CKD MSCs, leading to lower expression of inflammatory and fibrotic markers in kidney cells co-cultured with metformin-treated MSCs. Furthermore, metformin-treated CKD MSCs effectively reduce inflammation and fibrosis in diseased kidneys, suggesting a therapeutic benefit in targeting accelerated senescence of CKD MSCs.
Review
Immunology
Karima Landelouci, Shruti Sinha, Genevieve Pepin
Summary: Fanconi Anemia (FA) is a genome instability syndrome caused by mutations in repair genes, leading to congenital abnormalities, premature aging, and bone marrow failure. There is a close relationship between genome instability, inflammation, and the production of type-I Interferon. Understanding the molecular mechanisms of type-I Interferon activation in FA may lead to the discovery of therapeutic targets for the associated inflammation and premature aging.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Anda Huna, Audrey Griveau, David Vindrieux, Sara Jaber, Jean-Michel Flaman, Delphine Goehrig, Lamia Azzi, Jean-Jacques Medard, Sophia Djebali, Hector Hernandez-Vargas, Robert Dante, Lea Payen, Jacqueline Marvel, Philippe Bertolino, Sebastien Aubert, Pierre Dubus, David Bernard
Summary: The study reveals that PLA2R1 suppresses aging-induced tumors by repressing PARP1 expression and inducing DNA damage. Mechanistically, PLA2R1 represses PARP1 via a ROS-Rb signaling axis, leading to DNA damage and tumor suppressive responses in cells.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Benjamin Klein, Claudia Guenther
Summary: Type I interferons play a crucial role in autoimmune disorders and interferonopathies, but uncontrolled activation may lead to autoinflammation and autoimmunity. Various mechanisms promote IFN secretion upon increased DNA damage, which is similar to the features seen in hereditary cutaneous DNA damage syndromes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Yueyan Liao, Xiangyu Ke, Tianyi Deng, Qingsong Qin
Summary: Human cytomegalovirus (HCMV) is a common opportunistic pathogen with no available vaccine for prevention of associated diseases. Eltanexor effectively inhibits HCMV replication by suppressing viral gene expression and promoting proteasome-mediated degradation of XPO1, resulting in increased expression of type I interferon.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago
Summary: This study reveals that the rotavirus NSP1 protein can antagonize the induction of type III and type I interferons, and it is an effective inhibitor of IRF-1, which helps in evading antiviral immunity in the intestinal epithelium.
Article
Developmental Biology
Vijay Pratap Singh, Huzaifa Hassan, Fengyan Deng, Dai Tsuchiya, Sean McKinney, Kevin Ferro, Jennifer L. Gerton
Summary: This paper explores the role of polyploidy in the murine placenta and identifies Myc as a key regulator of polyploidy and placental development. The study shows that Myc is essential for multiple rounds of DNA replication, supports gene expression involved in replication and nucleotide biosynthesis, and prevents DNA damage and premature senescence in trophoblast giant cells.
Article
Immunology
Xin Zhao, Wenji Huang, Yanjie Shi, Jiahong Guo, Hehe Xiao, Ning Ji, Jianhua Feng, Huifeng Dang, Jun Zou
Summary: PLAAT1 plays important roles in tumor suppression, transglutaminase activation, and peroxisomal biogenesis. This study shows that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to degrade them.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Michelle L. Swift, Christian Sell, Jane Azizkhan-Clifford
Summary: The study reveals that persistent DNA damage leads to degradation of Sp1 protein and an increase in cellular senescence markers. Further experiments demonstrate that specific mutations can prevent the degradation of Sp1 and slow down cellular senescence.
Article
Microbiology
Huimin Liu, Chen Li, Wenfeng He, Jing Chen, Guoqing Yang, Lu Chen, Hongtao Chang
Summary: This study demonstrates the importance of free ISG15 in inhibiting PRV growth and promoting IFN-alpha-mediated antiviral activity. The interaction between ISG15 and STAT2 plays a key role in this process.
Article
Endocrinology & Metabolism
Chao Xia, Tianyuan Jiang, Yonghui Wang, Xiaoting Chen, Yan Hu, Yanhong Gao
Summary: The study revealed that p53/miR-145a axis plays a role in promoting senescence and inhibiting osteogenesis of MSCs by targeting core binding factor beta (Cbfb) in osteogenic differentiation. These findings suggest that the p53/miR-145a/Cbfb axis may represent new targets in the treatment of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Hanfeng Wang, Yang Fan, Weihao Chen, Zheng Lv, Shengpan Wu, Yundong Xuan, Chenfeng Wang, Yongliang Lu, Tao Guo, Donglai Shen, Fan Zhang, Qingbo Huang, Yu Gao, Hongzhao Li, Xin Ma, Baojun Wang, Yan Huang, Xu Zhang
Summary: Recent studies have found that CMTM6 promotes tumor progression and modulates tumor immunity in clear cell renal cell carcinoma (ccRCC) by regulating programmed death-ligand 1 stability. Depletion of CMTM6 impairs the proliferation, migration, and invasion of ccRCC cells and promotes anti-tumor immunity. Loss of CMTM6 activates DNA damage response, leading to cellular senescence and upregulation of inflammatory factors.
Article
Endocrinology & Metabolism
Mei-Ling Wang, Rui Liu, Li-Mei Zhang, Bin Zhao, Rui Jia, Yang Zhao, Ya-Lin Xi, Jing-Xia Ma, He Ma
Summary: This article reports two cases of acute necrotizing encephalopathy (ANE) with acute onset, analyzing their clinical manifestations, laboratory examination, neuroimaging evidence, and treatment experience. One patient died, while the other patient's condition was controlled with appropriate treatment and showed good prognosis.
NEUROIMMUNOMODULATION
(2022)
Article
Oncology
Ajeya Nandi, Rahul Debnath, Anupma Nayak, Tsun Ki Jerrick To, Gatha Thacker, Megan Reilly, Sanjeev Gumber, Ilias Karagounis, Ning Li, Christopher J. Lengner, Malay Haldar, Alana L. Welm, Andres M. Blanco, Christoforos Thomas, Rumela Chakrabarti
Summary: This study reveals the cross-talk between Dll1(+) cancer cells and cancer-associated fibroblasts (CAF), which promotes metastasis and radioresistance. It opens up new therapeutic avenues for breast cancer patients.
Article
Endocrinology & Metabolism
Yuzhao Liu, Lu Gan, Bin Zhao, Kai Yu, Yangang Wang, Satu Mannisto, Stephanie J. Weinstein, Jiaqi Huang, Demetrius Albanes
Summary: In this study, a large population-based cohort was used to assess a wide range of metabolites and pathways related to type 2 diabetes. Several metabolites, including glucose, 1,5-anhydroglucitol, and mannose, were found to be significantly associated with type 2 diabetes. Various chemical class pathways, such as carbohydrates, amino acids, energy, and xenobiotics, were also identified to be significantly associated with type 2 diabetes. These findings provide new insights into the molecular basis of insulin resistance and the etiology of type 2 diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Editorial Material
Cell Biology
Louis R. Parham, Nicolette M. Johnson, Christopher J. Lengner, Kathryn E. Hamilton
Summary: Understanding how macroautophagy/autophagy contributes to tissue homeostasis is crucial for understanding organismal health. The intestinal epithelium, with its well-defined populations of intestinal stem cells, serves as an excellent model for studying tissue homeostasis regulation. Autophagy is identified as a lineage-agnostic marker of facultative intestinal stem cell (f-ISC) capacity in the mammalian intestine, enabling the prospective identification of f-ISCs within multiple lineages.
Review
Immunology
Mingjiu Zhao, Mengdi Zhang, Zhou Yang, Zhiguang Zhou, Jiaqi Huang, Bin Zhao
Summary: Since its emergence in 2019, COVID-19 has spread rapidly worldwide, causing a pervasive pandemic that has had profound effects on healthcare systems and the socio-economic environment. Numerous studies have focused on the pathogenic virus, SARS-CoV-2, in an effort to find ways to combat COVID-19. The ubiquitin-proteasome system (UPS) is recognized as a crucial mechanism for regulating human biological activities through the maintenance of protein homeostasis. This review aims to clarify the mechanisms by which the virus utilizes host E3 ubiquitin ligases and DUBs, along with its own viral proteins with similar enzyme activities, to facilitate invasion, replication, evasion, and inflammation. Understanding the role of E3 ubiquitin ligases and DUBs in COVID-19 can provide valuable insights for the development of antiviral therapies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Mingjiu Zhao, Yu Lei, Yanyan Zhou, Mingan Sun, Xia Li, Zhiguang Zhou, Jiaqi Huang, Xinyu Li, Bin Zhao
Summary: This study developed two risk assessment models for viral hepatitis based on metabolic pathways, which can evaluate disease progression and prognosis. By analyzing metabolic pathways, we found that immune cells play a significant role in metabolism, especially CD8+ T cells, macrophages, and NK cells. Maintaining metabolic homeostasis can reduce the risk of viral hepatitis progression and help decrease liver damage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Editorial Material
Immunology
Xiaoxi Lin, Yayi Gao, Yi Ding, Bin Zhao
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ping Zheng, Ning Zhang, Dabin Ren, Cong Yu, Bin Zhao, Qingke Bai, Yisong Zhang, Wanju Sun
Summary: In this study, we investigated the potential mechanisms of post-traumatic coagulopathy (PTC) in traumatic brain injury (TBI) patients using single cell RNA-sequencing and T cell repertoire (TCR)-sequencing. Our findings suggest that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Kensuke Sugiura, Yasunori Masuike, Kensuke Suzuki, Alice E. Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner, Anil K. Rustgi
Summary: The RNA-binding protein LIN28B is overexpressed in a significant portion of patients with colorectal cancer (CRC) and is associated with poor prognosis. This study uncovered a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and CRC metastasis. LIN28B directly binds to and posttranscriptionally regulates CLDN7 mRNA, leading to enhanced invasion, cell migration, and metastatic liver tumor formation. NOTCH3 was identified as a downstream effector of the LIN28B/CLDN1 axis and necessary for invasion and metastatic liver tumor formation. This discovery provides a promising new therapeutic option for metastatic CRC to the liver.
Article
Endocrinology & Metabolism
Ting Zhong, Binbin He, Xinyu Li, Kang Lei, Rong Tang, Bin Zhao, Xia Li
Summary: The aim of this study was to define a unique remission status in individuals with type 1 diabetes using the glycaemia risk index (GRI) and other continuous glucose monitoring (CGM) metrics. The study found that the patterns of CGM metrics associated with remission status were distinct, and that GRI, along with other traditional CGM metrics, could help identify different glycaemic variability patterns. This could potentially lead to specifically tailored monitoring and management strategies for individuals in different subclusters.
