The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases

PTBP3 promotes malignancy and hypoxia‐induced chemoresistance in pancreatic cancer cells by ATG12 up‐regulation

(2020) Jun Ma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Contributions of alternative splicing to muscle type development and function

(2020) Elena Nikonova et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM

(2019) Ruihui Xie et al.   CANCER LETTERS

Combinatorial regulation of alternative splicing

(2019) Hossein Shenasa et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α

(2019) Pingfu Hou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

(2019) Alessandro Bertero et al.   Nature Communications

Angiotensin II Influences Pre-mRNA Splicing Regulation by Enhancing RBM20 Transcription Through Activation of the MAPK/ELK1 Signaling Pathway

(2019) Hanfang Cai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RBM20 Regulates CaV1.2 Surface Expression by Promoting Exon 9* Inclusion of CACNA1C in Neonatal Rat Cardiomyocytes

(2019) Morinaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution

(2019) Jernej Ule et al.   MOLECULAR CELL

Rbm24, a target of p53, is necessary for proper expression of p53 and heart development

(2018) Min Zhang et al.   CELL DEATH AND DIFFERENTIATION

Mutations in voltage-gated L-type calcium channel: Implications in cardiac arrhythmia

(2018) Qing Zhang et al.   Channels

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling

(2018) Maarten M. G. van den Hoogenhof et al.   CIRCULATION

Splicing Factor RBM20 Regulates Transcriptional Network of Titin Associated and Calcium Handling Genes in The Heart

(2018) Wei Guo et al.   International Journal of Biological Sciences

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers

(2018) Elisa Monzón-Casanova et al.   NATURE IMMUNOLOGY

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4

(2018) Vita Dauksaite et al.   NUCLEIC ACIDS RESEARCH

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling

(2018) Martin Liss et al.   PLoS One

PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing

(2018) Xin Liang et al.   Cell Death & Disease

Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization

(2018) Rie Murayama et al.   Scientific Reports

Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20

(2018) Maimaiti Rexiati et al.   Genes

Exploring the Crosstalk Between LMNA and Splicing Machinery Gene Mutations in Dilated Cardiomyopathy

(2018) Hind C. Zahr et al.   Frontiers in Genetics

RNA binding protein 24 deletion disrupts global alternative splicing and causes dilated cardiomyopathy

(2018) Jing Liu et al.   Protein & Cell

RNA-binding proteins RBM20 and PTBP1 regulate the alternative splicing of FHOD3

(2018) P. Lorenzi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Screening for mutations in human cardiomyopathy- is RBM24 a new but rare disease gene?

(2018) Anna Gaertner et al.   Protein & Cell

The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice

(2017) Tomoki Ushijima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes

(2017) Katrin Streckfuss-Bömeke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Alternative splicing as a regulator of development and tissue identity

(2017) Francisco E. Baralle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ASpedia: a comprehensive encyclopedia of human alternative splicing

(2017) Daejin Hyung et al.   NUCLEIC ACIDS RESEARCH

Rules and tools to predict the splicing effects of exonic and intronic mutations

(2017) Kinji Ohno et al.   Wiley Interdisciplinary Reviews-RNA

A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank–Starling mechanism

(2016) Abdelaziz Beqqali et al.   CARDIOVASCULAR RESEARCH

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

(2016) Xiaochang Zhang et al.   CELL

Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association

(2016) Biykem Bozkurt et al.   CIRCULATION

RBM20 Regulates Circular RNA Production From the Titin Gene

(2016) Mohsin A Khan et al.   CIRCULATION RESEARCH

Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn)Novelty and Significance

(2016) Mathew Bull et al.   CIRCULATION RESEARCH

Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals

(2016) Elham Kayvanpour et al.   Clinical Research in Cardiology

Emerging Role for RBM20 and its Splicing Substrates in Cardiac Function and Heart Failure

(2016) Jipeng Ma et al.   CURRENT PHARMACEUTICAL DESIGN

RBM20 and RBM24 cooperatively promote the expression of shortenhsplice variants

(2016) Jumpei Ito et al.   FEBS LETTERS

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

(2016) Florian Hinze et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators

(2016) Miriam Llorian et al.   NUCLEIC ACIDS RESEARCH

Loss of β-adrenergic–stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure

(2016) Linghai Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of neuronal synapse specification by a highly dedicated alternative splicing program

(2016) L. Traunmuller et al.   SCIENCE

PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons

(2016) Jonathan P. Ling et al.   Cell Reports

MiasDB: A Database of Molecular Interactions Associated with Alternative Splicing of Human Pre-mRNAs

(2016) Yongqiang Xing et al.   PLoS One

Genome-wide analysis of alternative splicing during human heart development

(2016) He Wang et al.   Scientific Reports

Modeling structural and functional deficiencies ofRBM20familial dilated cardiomyopathy using human induced pluripotent stem cells

(2015) Saranya P. Wyles et al.   HUMAN MOLECULAR GENETICS

Insights into alternative splicing of sarcomeric genes in the heart

(2015) Cornelis J. Weeland et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer

(2015) H. Takahashi et al.   MOLECULAR CANCER THERAPEUTICS

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles

(2015) Bushra Raj et al.   NEURON

RBM20 is an essential factor for thyroid hormone-regulated titin isoform transition

(2015) Chaoqun Zhu et al.   Journal of Molecular Cell Biology

Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos

(2015) K. S. Tan et al.   Biology Open

Translational Control of Tropomyosin Expression in Vertebrate Hearts

(2014) Dipak K. Dube et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole

(2014) Mei Methawasin et al.   CIRCULATION

Gigantic Business

(2014) Wolfgang A. Linke et al.   CIRCULATION RESEARCH

RBM24 Is a Major Regulator of Muscle-Specific Alternative Splicing

(2014) Jiwen Yang et al.   DEVELOPMENTAL CELL

Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy

(2014) Rosanna Beraldi et al.   HUMAN MOLECULAR GENETICS

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

(2014) Henrike Maatz et al.   JOURNAL OF CLINICAL INVESTIGATION

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Pressure-Overload Cardiac Hypertrophy Is Associated with Distinct Alternative Splicing Due to Altered Expression of Splicing Factors

(2014) Taeyong Kim et al.   MOLECULES AND CELLS

Acute Pericarditis

(2014) Martin M. LeWinter   NEW ENGLAND JOURNAL OF MEDICINE

Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development

(2014) Jimena Giudice et al.   Nature Communications

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

(2014) Qin Li et al.   eLife

CaMKIIdelta subtypes: localization and function

(2014) Charles B. B. Gray et al.   Frontiers in Pharmacology

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

Titin Is a Major Human Disease Gene

(2013) Martin M. LeWinter et al.   CIRCULATION

Dilated Cardiomyopathy-Associated FHOD3 Variant Impairs the Ability to Induce Activation of Transcription Factor Serum Response Factor

(2013) Takuro Arimura et al.   CIRCULATION JOURNAL

Identification of nuclear retention domains in the RBM20 protein

(2013) Agnese Filippello et al.   FEBS LETTERS

New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein

(2013) Maria Romanelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart

(2013) J. Ye et al.   JOURNAL OF CELL SCIENCE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Rbm20 regulates titin alternative splicing as a splicing repressor

(2013) Shijun Li et al.   NUCLEIC ACIDS RESEARCH

Pathophysiological Defects and Transcriptional Profiling in the RBM20-/- Rat Model

(2013) Wei Guo et al.   PLoS One

Tuning the molecular giant titin through phosphorylation: Role in health and disease

(2013) Carlos Hidalgo et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The Alternative Heart: Impact of Alternative Splicing in Heart Disease

(2013) Enrique Lara-Pezzi et al.   Journal of Cardiovascular Translational Research

RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility

(2012) Kar Lai Poon et al.   CARDIOVASCULAR RESEARCH

Formin Homology 2 Domain Containing 3 Variants Associated With Hypertrophic Cardiomyopathy

(2012) Eric C. Wooten et al.   Circulation-Cardiovascular Genetics

Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

(2012) Niroshika Keppetipola et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks

(2012) Jonathan D. Ellis et al.   MOLECULAR CELL

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

(2012) Wei Guo et al.   NATURE MEDICINE

SpliceAid-F: a database of human splicing factors and their RNA-binding sites

(2012) Matteo Giulietti et al.   NUCLEIC ACIDS RESEARCH

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

(2012) N. L. Barbosa-Morais et al.   SCIENCE

LIM domains regulate protein kinase C activity: A novel molecular function

(2011) Andrés D. Maturana et al.   CELLULAR SIGNALLING

Decoding muscle alternative splicing

(2011) Miriam Llorian et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Transcriptional regulation of the human Raver2 ribonucleoprotein gene

(2011) Maria Grazia Romanelli et al.   GENE

Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy

(2011) Marwan M. Refaat et al.   HEART RHYTHM

Regulation of the Mutually Exclusive Exons 8a and 8 in the CaV1.2 Calcium Channel Transcript by Polypyrimidine Tract-binding Protein

(2011) Zhen Zhi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing

(2011) Jung-Chun Lin et al.   JOURNAL OF CELL BIOLOGY

Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats

(2011) Shijun Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

U1 snRNA Directly Interacts with Polypyrimidine Tract-Binding Protein during Splicing Repression

(2011) Shalini Sharma et al.   MOLECULAR CELL

Functional consequences of developmentally regulated alternative splicing

(2011) Auinash Kalsotra et al.   NATURE REVIEWS GENETICS

Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes

(2010) Sek Won Kong et al.   Circulation-Cardiovascular Genetics

Identification of Novel Mutations in RBM20 in Patients with Dilated Cardiomyopathy

(2010) Duanxiang Li et al.   CTS-Clinical and Translational Science

Stoichiometry of a regulatory splicing complex revealed by single-molecule analyses

(2010) Dmitry Cherny et al.   EMBO JOURNAL

Insulin signaling regulates cardiac titin properties in heart development and diabetic cardiomyopathy

(2010) Martina Krüger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

(2010) Miriam Llorian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Mammalian Formin Fhod3 Regulates Actin Assembly and Sarcomere Organization in Striated Muscles

(2009) Kenichiro Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Ribonucleic Acid Binding Protein Gene Cause Familial Dilated Cardiomyopathy

(2009) Katharine M. Brauch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

(2009) Yuanchao Xue et al.   MOLECULAR CELL

RNA processing and its regulation: global insights into biological networks

(2009) Donny D. Licatalosi et al.   NATURE REVIEWS GENETICS

Human Splicing Finder: an online bioinformatics tool to predict splicing signals

(2009) François-Olivier Desmet et al.   NUCLEIC ACIDS RESEARCH

Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

(2008) Kirsty Sawicka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

(2008) Shalini Sharma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression of Human nPTB Is Limited by Extreme Suboptimal Codon Content

(2008) Fiona Robinson et al.   PLoS One

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

(2008) A. Kalsotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA