The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases
Authors
Keywords
-
Journal
Genes
Volume 11, Issue 4, Pages 402
Publisher
MDPI AG
Online
2020-04-09
DOI
10.3390/genes11040402
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- PTBP3 promotes malignancy and hypoxia‐induced chemoresistance in pancreatic cancer cells by ATG12 up‐regulation
- (2020) Jun Ma et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Contributions of alternative splicing to muscle type development and function
- (2020) Elena Nikonova et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM
- (2019) Ruihui Xie et al. CANCER LETTERS
- Combinatorial regulation of alternative splicing
- (2019) Hossein Shenasa et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α
- (2019) Pingfu Hou et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
- (2019) Alessandro Bertero et al. Nature Communications
- Angiotensin II Influences Pre-mRNA Splicing Regulation by Enhancing RBM20 Transcription Through Activation of the MAPK/ELK1 Signaling Pathway
- (2019) Hanfang Cai et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- RBM20 Regulates CaV1.2 Surface Expression by Promoting Exon 9* Inclusion of CACNA1C in Neonatal Rat Cardiomyocytes
- (2019) Morinaga et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution
- (2019) Jernej Ule et al. MOLECULAR CELL
- Rbm24, a target of p53, is necessary for proper expression of p53 and heart development
- (2018) Min Zhang et al. CELL DEATH AND DIFFERENTIATION
- Mutations in voltage-gated L-type calcium channel: Implications in cardiac arrhythmia
- (2018) Qing Zhang et al. Channels
- RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling
- (2018) Maarten M. G. van den Hoogenhof et al. CIRCULATION
- Splicing Factor RBM20 Regulates Transcriptional Network of Titin Associated and Calcium Handling Genes in The Heart
- (2018) Wei Guo et al. International Journal of Biological Sciences
- The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers
- (2018) Elisa Monzón-Casanova et al. NATURE IMMUNOLOGY
- Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4
- (2018) Vita Dauksaite et al. NUCLEIC ACIDS RESEARCH
- Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling
- (2018) Martin Liss et al. PLoS One
- PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing
- (2018) Xin Liang et al. Cell Death & Disease
- Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization
- (2018) Rie Murayama et al. Scientific Reports
- Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20
- (2018) Maimaiti Rexiati et al. Genes
- Exploring the Crosstalk Between LMNA and Splicing Machinery Gene Mutations in Dilated Cardiomyopathy
- (2018) Hind C. Zahr et al. Frontiers in Genetics
- RNA binding protein 24 deletion disrupts global alternative splicing and causes dilated cardiomyopathy
- (2018) Jing Liu et al. Protein & Cell
- RNA-binding proteins RBM20 and PTBP1 regulate the alternative splicing of FHOD3
- (2018) P. Lorenzi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Screening for mutations in human cardiomyopathy- is RBM24 a new but rare disease gene?
- (2018) Anna Gaertner et al. Protein & Cell
- The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice
- (2017) Tomoki Ushijima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes
- (2017) Katrin Streckfuss-Bömeke et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Translation of CircRNAs
- (2017) Nagarjuna Reddy Pamudurti et al. MOLECULAR CELL
- Alternative splicing as a regulator of development and tissue identity
- (2017) Francisco E. Baralle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ASpedia: a comprehensive encyclopedia of human alternative splicing
- (2017) Daejin Hyung et al. NUCLEIC ACIDS RESEARCH
- Rules and tools to predict the splicing effects of exonic and intronic mutations
- (2017) Kinji Ohno et al. Wiley Interdisciplinary Reviews-RNA
- A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank–Starling mechanism
- (2016) Abdelaziz Beqqali et al. CARDIOVASCULAR RESEARCH
- Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex
- (2016) Xiaochang Zhang et al. CELL
- Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association
- (2016) Biykem Bozkurt et al. CIRCULATION
- RBM20 Regulates Circular RNA Production From the Titin Gene
- (2016) Mohsin A Khan et al. CIRCULATION RESEARCH
- Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn)Novelty and Significance
- (2016) Mathew Bull et al. CIRCULATION RESEARCH
- Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals
- (2016) Elham Kayvanpour et al. Clinical Research in Cardiology
- Emerging Role for RBM20 and its Splicing Substrates in Cardiac Function and Heart Failure
- (2016) Jipeng Ma et al. CURRENT PHARMACEUTICAL DESIGN
- RBM20 and RBM24 cooperatively promote the expression of shortenhsplice variants
- (2016) Jumpei Ito et al. FEBS LETTERS
- Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy
- (2016) Florian Hinze et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators
- (2016) Miriam Llorian et al. NUCLEIC ACIDS RESEARCH
- Loss of β-adrenergic–stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure
- (2016) Linghai Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of neuronal synapse specification by a highly dedicated alternative splicing program
- (2016) L. Traunmuller et al. SCIENCE
- PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons
- (2016) Jonathan P. Ling et al. Cell Reports
- MiasDB: A Database of Molecular Interactions Associated with Alternative Splicing of Human Pre-mRNAs
- (2016) Yongqiang Xing et al. PLoS One
- Genome-wide analysis of alternative splicing during human heart development
- (2016) He Wang et al. Scientific Reports
- Modeling structural and functional deficiencies ofRBM20familial dilated cardiomyopathy using human induced pluripotent stem cells
- (2015) Saranya P. Wyles et al. HUMAN MOLECULAR GENETICS
- Insights into alternative splicing of sarcomeric genes in the heart
- (2015) Cornelis J. Weeland et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer
- (2015) H. Takahashi et al. MOLECULAR CANCER THERAPEUTICS
- Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles
- (2015) Bushra Raj et al. NEURON
- RBM20 is an essential factor for thyroid hormone-regulated titin isoform transition
- (2015) Chaoqun Zhu et al. Journal of Molecular Cell Biology
- Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos
- (2015) K. S. Tan et al. Biology Open
- Translational Control of Tropomyosin Expression in Vertebrate Hearts
- (2014) Dipak K. Dube et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole
- (2014) Mei Methawasin et al. CIRCULATION
- Gigantic Business
- (2014) Wolfgang A. Linke et al. CIRCULATION RESEARCH
- RBM24 Is a Major Regulator of Muscle-Specific Alternative Splicing
- (2014) Jiwen Yang et al. DEVELOPMENTAL CELL
- Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy
- (2014) Rosanna Beraldi et al. HUMAN MOLECULAR GENETICS
- RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing
- (2014) Henrike Maatz et al. JOURNAL OF CLINICAL INVESTIGATION
- circRNA Biogenesis Competes with Pre-mRNA Splicing
- (2014) Reut Ashwal-Fluss et al. MOLECULAR CELL
- Pressure-Overload Cardiac Hypertrophy Is Associated with Distinct Alternative Splicing Due to Altered Expression of Splicing Factors
- (2014) Taeyong Kim et al. MOLECULES AND CELLS
- Acute Pericarditis
- (2014) Martin M. LeWinter NEW ENGLAND JOURNAL OF MEDICINE
- Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development
- (2014) Jimena Giudice et al. Nature Communications
- The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
- (2014) Qin Li et al. eLife
- CaMKIIdelta subtypes: localization and function
- (2014) Charles B. B. Gray et al. Frontiers in Pharmacology
- Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits
- (2013) Yuanchao Xue et al. CELL
- Titin Is a Major Human Disease Gene
- (2013) Martin M. LeWinter et al. CIRCULATION
- Dilated Cardiomyopathy-Associated FHOD3 Variant Impairs the Ability to Induce Activation of Transcription Factor Serum Response Factor
- (2013) Takuro Arimura et al. CIRCULATION JOURNAL
- Identification of nuclear retention domains in the RBM20 protein
- (2013) Agnese Filippello et al. FEBS LETTERS
- New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein
- (2013) Maria Romanelli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart
- (2013) J. Ye et al. JOURNAL OF CELL SCIENCE
- Circular RNAs are a large class of animal RNAs with regulatory potency
- (2013) Sebastian Memczak et al. NATURE
- Rbm20 regulates titin alternative splicing as a splicing repressor
- (2013) Shijun Li et al. NUCLEIC ACIDS RESEARCH
- Pathophysiological Defects and Transcriptional Profiling in the RBM20-/- Rat Model
- (2013) Wei Guo et al. PLoS One
- Tuning the molecular giant titin through phosphorylation: Role in health and disease
- (2013) Carlos Hidalgo et al. TRENDS IN CARDIOVASCULAR MEDICINE
- The Alternative Heart: Impact of Alternative Splicing in Heart Disease
- (2013) Enrique Lara-Pezzi et al. Journal of Cardiovascular Translational Research
- RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility
- (2012) Kar Lai Poon et al. CARDIOVASCULAR RESEARCH
- Formin Homology 2 Domain Containing 3 Variants Associated With Hypertrophic Cardiomyopathy
- (2012) Eric C. Wooten et al. Circulation-Cardiovascular Genetics
- Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2
- (2012) Niroshika Keppetipola et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks
- (2012) Jonathan D. Ellis et al. MOLECULAR CELL
- RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
- (2012) Wei Guo et al. NATURE MEDICINE
- SpliceAid-F: a database of human splicing factors and their RNA-binding sites
- (2012) Matteo Giulietti et al. NUCLEIC ACIDS RESEARCH
- The Evolutionary Landscape of Alternative Splicing in Vertebrate Species
- (2012) N. L. Barbosa-Morais et al. SCIENCE
- LIM domains regulate protein kinase C activity: A novel molecular function
- (2011) Andrés D. Maturana et al. CELLULAR SIGNALLING
- Decoding muscle alternative splicing
- (2011) Miriam Llorian et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Transcriptional regulation of the human Raver2 ribonucleoprotein gene
- (2011) Maria Grazia Romanelli et al. GENE
- Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy
- (2011) Marwan M. Refaat et al. HEART RHYTHM
- Regulation of the Mutually Exclusive Exons 8a and 8 in the CaV1.2 Calcium Channel Transcript by Polypyrimidine Tract-binding Protein
- (2011) Zhen Zhi Tang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing
- (2011) Jung-Chun Lin et al. JOURNAL OF CELL BIOLOGY
- Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats
- (2011) Shijun Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- U1 snRNA Directly Interacts with Polypyrimidine Tract-Binding Protein during Splicing Repression
- (2011) Shalini Sharma et al. MOLECULAR CELL
- Functional consequences of developmentally regulated alternative splicing
- (2011) Auinash Kalsotra et al. NATURE REVIEWS GENETICS
- Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes
- (2010) Sek Won Kong et al. Circulation-Cardiovascular Genetics
- Identification of Novel Mutations in RBM20 in Patients with Dilated Cardiomyopathy
- (2010) Duanxiang Li et al. CTS-Clinical and Translational Science
- Stoichiometry of a regulatory splicing complex revealed by single-molecule analyses
- (2010) Dmitry Cherny et al. EMBO JOURNAL
- Insulin signaling regulates cardiac titin properties in heart development and diabetic cardiomyopathy
- (2010) Martina Krüger et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB
- (2010) Miriam Llorian et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Regulation of Alternative Splicing by Histone Modifications
- (2010) R. F. Luco et al. SCIENCE
- Jalview Version 2--a multiple sequence alignment editor and analysis workbench
- (2009) A. M. Waterhouse et al. BIOINFORMATICS
- Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes
- (2009) J Zhang et al. CELL DEATH AND DIFFERENTIATION
- Mammalian Formin Fhod3 Regulates Actin Assembly and Sarcomere Organization in Striated Muscles
- (2009) Kenichiro Taniguchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in Ribonucleic Acid Binding Protein Gene Cause Familial Dilated Cardiomyopathy
- (2009) Katharine M. Brauch et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping
- (2009) Yuanchao Xue et al. MOLECULAR CELL
- RNA processing and its regulation: global insights into biological networks
- (2009) Donny D. Licatalosi et al. NATURE REVIEWS GENETICS
- Human Splicing Finder: an online bioinformatics tool to predict splicing signals
- (2009) François-Olivier Desmet et al. NUCLEIC ACIDS RESEARCH
- Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein
- (2008) Kirsty Sawicka et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome
- (2008) Shalini Sharma et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Expression of Human nPTB Is Limited by Extreme Suboptimal Codon Content
- (2008) Fiona Robinson et al. PLoS One
- A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
- (2008) A. Kalsotra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started