期刊
FEBS LETTERS
卷 587, 期 18, 页码 2989-2995出版社
WILEY
DOI: 10.1016/j.febslet.2013.07.018
关键词
RBM20; DCM; Alternative splicing; Nuclear localization; Ribonucleoprotein; SR
资金
- AIRC
- MIUR, Italy
RBM20 is a nuclear protein which regulates alternative splicing of expressed genes that have a key role in cardiac function. By cloning the human and mouse RBM20 cDNA, producing expressing vectors for truncated proteins, and comparing their sub-cellular distribution in transfected cells, we have identified the sequences necessary for RBM20 full nuclear retention. The region overlaps an RNA binding motif and a serine-arginine domain. The sequence is conserved in many species but belongs only to RBM20 orthologs. The RMB20 tissue specificity, together with the properties of its nuclear localization determinant, demonstrates a specific evolutionary selection of post-transcriptional regulation factors. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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