Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?

AdipoRon , a new therapeutic prospect for Duchenne muscular dystrophy

(2020) Michel Abou‐Samra et al.   Journal of Cachexia Sarcopenia and Muscle

AdipoRon improves cognitive dysfunction of Alzheimer’s disease and rescues impaired neural stem cell proliferation through AdipoR1/AMPK pathway

(2020) Bin Liu et al.   EXPERIMENTAL NEUROLOGY

Adiponectin promotes muscle regeneration through binding to T-cadherin

(2019) Yoshimitsu Tanaka et al.   Scientific Reports

Adipokines and Aging: Findings From Centenarians and the Very Old

(2019) Yasumichi Arai et al.   Frontiers in Endocrinology

Role of adiponectin in the metabolism of skeletal muscles in collagen VI–related myopathies

(2019) Tania Gamberi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Adiponectin—Consideration for its Role in Skeletal Muscle Health

(2019) Matthew Krause et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adiponectin in Myopathies

(2019) Tania Gamberi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adiponectin Protects Against Cerebral Ischemic Injury Through AdipoR1/AMPK Pathways

(2019) Bin Liu et al.   Frontiers in Pharmacology

Sarcopenia

(2019) Alfonso J Cruz-Jentoft et al.   LANCET

Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy

(2019) Yetrib Hathout et al.   Scientific Reports

Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin

(2019) Shunbun Kita et al.   eLife

Oxidative stress in exercise training: the involvement of inflammation and peripheral signals

(2019) Francesca Magherini et al.   FREE RADICAL RESEARCH

Skeletal muscle adiponectin induction in obesity and exercise

(2019) Sergio F. Martinez-Huenchullan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

(2019) Ying Liu et al.   Frontiers in Endocrinology

Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

(2018) Raphaël Boursereau et al.   BMC BIOLOGY

Regulation and phylogeny of skeletal muscle regeneration

(2018) Meryem B. Baghdadi et al.   DEVELOPMENTAL BIOLOGY

A collagen domain–derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms

(2018) Mohd Sayeed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes

(2018) Yaeni Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel phytopeptide osmotin mimics preventive effects of adiponectin on vascular inflammation and atherosclerosis

(2018) Yui Takahashi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer’s Disease

(2018) Gwangho Yoon et al.   MOLECULAR NEUROBIOLOGY

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

(2018) Fengjiao Sun et al.   MOLECULAR PSYCHIATRY

Discovery of a novel potent peptide agonist to adiponectin receptor 1

(2018) Sunghwan Kim et al.   PLoS One

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

(2018) John A. Batsis et al.   Nature Reviews Endocrinology

Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis

(2018) Miho Akimoto et al.   Cell Death & Disease

An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis

(2018) Takashi Yamashita et al.   Scientific Reports

Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression

(2018) Sarah Nicolas et al.   Translational Psychiatry

Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse models

(2018) Ashfaq Ahmad et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cellular and molecular mechanisms of sarcopenia: the S100B perspective

(2018) Francesca Riuzzi et al.   Journal of Cachexia Sarcopenia and Muscle

A potent peptide as adiponectin receptor 1 agonist to against fibrosis

(2017) Lingman Ma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Objective Measures of Physical Activity and Cardiometabolic and Endocrine Biomarkers

(2017) HALA B. ALESSA et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy

(2017) Abhishek Kumar Singh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer's disease

(2017) Faiz Ul Amin et al.   Nanoscale

The burden, epidemiology, costs and treatment for Duchenne muscular dystrophy: an evidence review

(2017) S. Ryder et al.   Orphanet Journal of Rare Diseases

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis

(2017) Peter S. Zammit   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth

(2017) Fanuel Messaggio et al.   Oncotarget

Osmotin Protects H9c2 Cells from Simulated Ischemia-Reperfusion Injury through AdipoR1/PI3K/AKT Signaling Pathway

(2017) Jianhua Liu et al.   Frontiers in Physiology

New targets to alleviate skeletal muscle inflammation: role of microRNAs regulated by adiponectin

(2017) Raphaël Boursereau et al.   Scientific Reports

Activation of autophagy by globular adiponectin is required for muscle differentiation

(2016) Tania Gamberi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice

(2016) Di Zhang et al.   ENDOCRINOLOGY

Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice

(2016) Ying Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Inflammation et régénération musculaire

(2016) Sébastien S. Dufresne et al.   M S-MEDECINE SCIENCES

Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action

(2016) Kwangseok Hong et al.   MICROCIRCULATION

Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors

(2016) D Zhang et al.   MOLECULAR PSYCHIATRY

Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

(2016) S A Shah et al.   MOLECULAR PSYCHIATRY

Adiponectin, the past two decades

(2016) Zhao V. Wang et al.   Journal of Molecular Cell Biology

Adiponectin signaling and function in insulin target tissues

(2016) Hong Ruan et al.   Journal of Molecular Cell Biology

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway

(2016) Haroon Badshah et al.   Scientific Reports

Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice

(2016) Aiko Inoue et al.   Journal of Cachexia Sarcopenia and Muscle

AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings

(2015) Yanqing Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior

(2015) Joëlle Chabry et al.   BRAIN BEHAVIOR AND IMMUNITY

Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway

(2015) P G F Quaresma et al.   INTERNATIONAL JOURNAL OF OBESITY

Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

(2015) Tahir Ali et al.   Scientific Reports

Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin

(2015) S. Anil Kumar et al.   Frontiers in Plant Science

Involvement of adiponectin in the pathogenesis of dystrophinopathy

(2015) Michel Abou-Samra et al.   Skeletal Muscle

Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity

(2015) Miki Okada-Iwabu et al.   Diabetes & Metabolism Journal

Orally Active Osteoanabolic Agent GTDF Binds to Adiponectin Receptors, With a Preference for AdipoR1, Induces Adiponectin-Associated Signaling, and Improves Metabolic Health in a Rodent Model of Diabetes

(2014) A. K. Singh et al.   DIABETES

The role of AMPK in controlling metabolism and mitochondrial biogenesis during exercise

(2014) Katarina Marcinko et al.   EXPERIMENTAL PHYSIOLOGY

Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients

(2014) Yetrib Hathout et al.   HUMAN MOLECULAR GENETICS

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

(2014) S. Y. Yau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of second generation peptides modulating cellular adiponectin receptor responses

(2014) Laszlo Otvos et al.   Frontiers in Chemistry

Adiponectin increases glucose-induced insulin secretion through the activation of lipid oxidation

(2013) G. Patané et al.   ACTA DIABETOLOGICA

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

Adiponectin as a tissue regenerating hormone: more than a metabolic function

(2013) Tania Fiaschi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

T-cadherin Is Essential for Adiponectin-mediated Revascularization

(2013) Jennifer L. Parker-Duffen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokines and Chemokines as Regulators of Skeletal Muscle Inflammation: Presenting the Case of Duchenne Muscular Dystrophy

(2013) Boel De Paepe et al.   MEDIATORS OF INFLAMMATION

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

Adiponectin signaling in the liver

(2013) Terry P. Combs et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Ronning After the Adiponectin Receptors

(2013) W. L. Holland et al.   SCIENCE

Adiponectin and Skeletal Muscle

(2012) Julie Jortay et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of PGC-1α signaling in skeletal muscle health and disease

(2012) Chounghun Kang et al.   Annals of the New York Academy of Sciences

The Role of Adiponectin in Cancer: A Review of Current Evidence

(2012) Maria Dalamaga et al.   ENDOCRINE REVIEWS

The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells

(2012) Petra S. Eisele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Globular Adiponectin Activates Motility and Regenerative Traits of Muscle Satellite Cells

(2012) Tania Fiaschi et al.   PLoS One

Adipokines identified as new downstream targets for adiponectin: lessons from adiponectin-overexpressing or -deficient mice

(2011) Qian Ge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

(2011) Laszlo Otvos et al.   BMC BIOTECHNOLOGY

Adiponectin receptor signalling in the brain

(2011) John Thundyil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Decreased concentration of adiponectin together with a selective reduction of its high molecular weight oligomers is involved in metabolic complications of myotonic dystrophy type 1

(2011) Aurora Daniele et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese–diabetic mice

(2011) Tsuyoshi Goto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The collagen VI-related myopathies: muscle meets its matrix

(2011) Carsten G. Bönnemann   Nature Reviews Neurology

Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat

(2011) Elahe Talebi Garekani et al.   PEPTIDES

Hippocampal Neurogenesis and Dendritic Plasticity Support Running-Improved Spatial Learning and Depression-Like Behaviour in Stressed Rats

(2011) Suk-Yu Yau et al.   PLoS One

Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice

(2011) HUHE CHAOLU et al.   Experimental and Therapeutic Medicine

Anabolic and catabolic pathways regulating skeletal muscle mass

(2010) John J McCarthy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Local Induction of Adiponectin Reduces Lipopolysaccharide-Triggered Skeletal Muscle Damage

(2010) Julie Jortay et al.   ENDOCRINOLOGY

Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion

(2010) Nadeeja Wijesekara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cadherin is critical for adiponectin-mediated cardioprotection in mice

(2010) Martin S. Denzel et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF- B

(2010) X. D. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Globular Adiponectin as a Complete Mesoangioblast Regulator: Role in Proliferation, Survival, Motility, and Skeletal Muscle Differentiation

(2010) Tania Fiaschi et al.   MOLECULAR BIOLOGY OF THE CELL

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Globular adiponectin induces differentiation and fusion of skeletal muscle cells

(2009) Tania Fiaschi et al.   CELL RESEARCH

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

(2009) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

(2009) Lijun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

(2009) E. Maury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function

(2008) Matthew P. Krause et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY