Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway

The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus

(2013) G. Daniele et al.   ACTA DIABETOLOGICA

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

(2013) Devjit Tripathy et al.   DIABETOLOGIA

Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats

(2013) Gisele Castro et al.   FEBS Open Bio

AMP-activated protein kinase: new regulation, new roles?

(2012) David Carling et al.   BIOCHEMICAL JOURNAL

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

Topiramate Treatment Improves Hypothalamic Insulin and Leptin Signaling and Action and Reduces Obesity in Mice

(2012) Andrea M. Caricilli et al.   ENDOCRINOLOGY

AMPK and the neuroendocrine regulation of appetite and energy expenditure

(2012) Romana Stark et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neuronal circuits involving neuropeptide Y in hypothalamic arcuate nucleus-mediated feeding regulation

(2012) Haruaki Kageyama et al.   NEUROPEPTIDES

Thiazolidinediones and PPARγ agonists: time for a reassessment

(2012) Bertrand Cariou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pioglitazone in Clinical Practice: Where Are We Now?

(2012) Joytish Govindan et al.   Diabetes Therapy

The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys

(2011) Christine R Swanson et al.   Journal of Neuroinflammation

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

Brain PPAR-γ promotes obesity and is required for the insulin–sensitizing effect of thiazolidinediones

(2011) Min Lu et al.   NATURE MEDICINE

A role for central nervous system PPAR-γ in the regulation of energy balance

(2011) Karen K Ryan et al.   NATURE MEDICINE

CNS leptin and insulin action in the control of energy homeostasis

(2010) Bengt F. Belgardt et al.   Annals of the New York Academy of Sciences

Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

(2009) A. Monroy et al.   DIABETOLOGIA

Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

(2009) T Yamauchi et al.   INTERNATIONAL JOURNAL OF OBESITY

Expression of Peroxisome Proliferator-Activated Receptor-γ in Key Neuronal Subsets Regulating Glucose Metabolism and Energy Homeostasis

(2008) David A. Sarruf et al.   ENDOCRINOLOGY

Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons

(2008) E Guillod-Maximin et al.   JOURNAL OF ENDOCRINOLOGY

Role of hypothalamic AMP-kinase in food intake regulation

(2008) Yasuhiko Minokoshi et al.   NUTRITION