Adiponectin signaling in the liver

Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance

(2013) Y Ma et al.   GENE THERAPY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1

(2012) Matthew M. Molusky et al.   DIABETES

The Role of Adiponectin in Cancer: A Review of Current Evidence

(2012) Maria Dalamaga et al.   ENDOCRINE REVIEWS

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy

(2011) Mantong Zhao et al.   Cell Metabolism

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

(2011) Motoharu Awazawa et al.   Cell Metabolism

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

(2011) Yi Wang et al.   DIABETES

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

(2011) Russell A. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

Adiponectin Lowers Glucose Production by Increasing SOGA

(2010) Rachael B. Cowerd et al.   AMERICAN JOURNAL OF PATHOLOGY

The Physiological Deadlock between AMPK and Gluconeogenesis

(2010) Josephine M. Forbes   AMERICAN JOURNAL OF PATHOLOGY

Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans

(2010) H. Oberkofler et al.   DIABETOLOGIA

Adiponectin receptor binding proteins - recent advances in elucidating adiponectin signalling pathways

(2010) Christa Buechler et al.   FEBS LETTERS

T-cadherin is critical for adiponectin-mediated cardioprotection in mice

(2010) Martin S. Denzel et al.   JOURNAL OF CLINICAL INVESTIGATION

Hydroxychloroquine and Glycemia in Women with Rheumatoid Arthritis and Systemic Lupus Erythematosus

(2010) S. K. PENN et al.   JOURNAL OF RHEUMATOLOGY

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Increased Hepatic Insulin Action in Diet-Induced Obese Mice Following Inhibition of Glucosylceramide Synthase

(2010) Nelson S. Yew et al.   PLoS One

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

(2009) Kenneth K.Y. Cheng et al.   Cell Metabolism

Lipopolysaccharide inhibition of glucose production through the Toll-like receptor-4, myeloid differentiation factor 88, and nuclear factor κb pathway

(2009) Carl F. Raetzsch et al.   HEPATOLOGY

Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

(2009) Lijun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

(2009) Changhua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APPL1: role in adiponectin signaling and beyond

(2008) Sathyaseelan S. Deepa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism

(2008) L. Qiao et al.   DIABETES

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

Plasma Adiponectin Complexes Have Distinct Biochemical Characteristics

(2008) Todd Schraw et al.   ENDOCRINOLOGY

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

(2008) Archana Mukhopadhyay et al.   FASEB JOURNAL

High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-κB activation in vascular endothelial cells

(2008) Yoshiyuki Hattori et al.   FEBS LETTERS

Sphingolipids Function as Downstream Effectors of a Fungal PAQR

(2008) N. Y. Villa et al.   MOLECULAR PHARMACOLOGY

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS