Gene transcription and chromatin regulation in hypoxia

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

(2020) Pearl Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

(2019) Michael Batie et al.   SCIENCE

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

(2019) Abhishek A. Chakraborty et al.   SCIENCE

mRNA-to-protein translation in hypoxia

(2019) Nancy T. Chee et al.   Molecular Cancer

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

(2019) Strowitzki et al.   Cells

Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer

(2019) Diego Camuzi et al.   Cells

The role of 3D genome organization in development and cell differentiation

(2019) Hui Zheng et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

When is a target not a target?

(2019) David C Bersten et al.   eLife

Substrates of PHD

(2019) Frank S. Lee   Cell Metabolism

HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters

(2018) Norio Suzuki et al.   EXPERIMENTAL CELL RESEARCH

Oxygen availability and metabolic reprogramming in cancer

(2017) Hong Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia

(2017) Maria Tiana et al.   NUCLEIC ACIDS RESEARCH

G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis

(2017) Francesco Casciello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KDM2 Family Members are Regulated by HIF-1 in Hypoxia

(2017) Michael Batie et al.   Cells

KDM4A regulates HIF-1 levels through H3K9me3

(2017) Grzegorz Dobrynin et al.   Scientific Reports

Capture‐C reveals preformed chromatin interactions between HIF‐binding sites and distant promoters

(2016) James L Platt et al.   EMBO REPORTS

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

(2016) Peggy Prickaerts et al.   Epigenetics & Chromatin

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

(2016) Xue Gao et al.   Nature Communications

The TIP60 Complex Is a Conserved Coactivator of HIF1A

(2016) Joel I. Perez-Perri et al.   Cell Reports

H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK

(2015) M M Olcina et al.   ONCOGENE

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer

(2015) Rafik Salama et al.   PLoS One

Epigenetic regulation by histone demethylases in hypoxia

(2015) Rebecca L Hancock et al.   Epigenomics

Chromatin and oxygen sensing in the context of JmjC histone demethylases

(2014) Alena Shmakova et al.   BIOCHEMICAL JOURNAL

Histone variants: dynamic punctuation in transcription

(2014) C. M. Weber et al.   GENES & DEVELOPMENT

Quantitative Profiling of Chromatome Dynamics Reveals a Novel Role for HP1BP3 in Hypoxia-induced Oncogenesis

(2014) Bamaprasad Dutta et al.   MOLECULAR & CELLULAR PROTEOMICS

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Pan-genomic binding of hypoxia-inducible transcription factors

(2013) Johannes Schödel et al.   BIOLOGICAL CHEMISTRY

Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes

(2013) Geeta J. Narlikar et al.   CELL

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2

(2013) Hani Choudhry et al.   EMBO REPORTS

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

(2013) Monica M. Olcina et al.   MOLECULAR CELL

Making sense of transcribing chromatin

(2012) Tom Owen-Hughes et al.   CURRENT OPINION IN CELL BIOLOGY

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression

(2012) Johannes Schödel et al.   NATURE GENETICS

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

(2012) Karolin Luger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms and potential functions of histone demethylases

(2012) Susanne Marije Kooistra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

(2012) W. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The VHL/HIF axis in clear cell renal carcinoma

(2012) Chuan Shen et al.   SEMINARS IN CANCER BIOLOGY

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1  and Transcriptional Upregulation of MAT2A in Hepatoma Cells

(2011) Q. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1α to reverse HRE site in the promoter

(2010) Kyung Ju Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase

(2010) X. Zhou et al.   CANCER RESEARCH

Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity

(2010) Michaela Tausendschön et al.   CYTOKINE

Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

(2010) Amaya Ortiz-Barahona et al.   NUCLEIC ACIDS RESEARCH

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia

(2009) Xiaobo Xia et al.   GENOME BIOLOGY

Regulation of gene expression by hypoxia

(2008) Niall Steven Kenneth et al.   BIOCHEMICAL JOURNAL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

(2008) Amber Buescher Johnson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS