Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

(2020) Alejandro Moreno-Domínguez et al.   Science Signaling

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

(2019) Michael Batie et al.   SCIENCE

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

(2019) Abhishek A. Chakraborty et al.   SCIENCE

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis

(2019) Tslil Ast et al.   CELL

Metabolite Exchange between Mammalian Organs Quantified in Pigs

(2019) Cholsoon Jang et al.   Cell Metabolism

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

(2019) Matteo Morotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

(2019) Norma Masson et al.   SCIENCE

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

(2019) Matthew E Cockman et al.   eLife

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation

(2019) Isha H. Jain et al.   Cell Metabolism

Substrates of PHD

(2019) Frank S. Lee   Cell Metabolism

HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients

(2019) Kevin D Courtney et al.   CLINICAL CANCER RESEARCH

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

(2018) Debangshu Samanta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

(2018) Zandra E. Walton et al.   CELL

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers

(2018) Hong Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer

(2018) Mei Ding et al.   MOLECULAR CANCER RESEARCH

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

(2018) Javier Garcia-Bermudez et al.   NATURE CELL BIOLOGY

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats

(2018) Patricia Siques et al.   Frontiers in Physiology

Effects of four weeks intermittent hypoxia intervention on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, and Akt activity in skeletal muscle of obese mice with type 2 diabetes

(2018) Yun Wang et al.   PLoS One

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy

(2018) Chenyao Wang et al.   Nature Communications

Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation

(2018) Daniel Ackerman et al.   Cell Reports

Impaired Hypoxic Pulmonary Vasoconstriction in a Mouse Model of Leigh Syndrome

(2018) Grigorij Schleifer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-induced regulation of mTOR signaling by miR-7 targeting REDD1

(2018) Minhyeong Seong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oxygen availability and metabolic reprogramming in cancer

(2017) Hong Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

(2017) Andrew M Intlekofer et al.   Nature Chemical Biology

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer

(2017) Maria Victoria Recouvreux et al.   Frontiers in Endocrinology

CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria

(2017) Luke W. Thomas et al.   Frontiers in Oncology

Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox

(2016) Debangshu Samanta et al.   CANCER RESEARCH

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

(2016) Kimberly J. Briggs et al.   CELL

Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction

(2016) Junli Liu et al.   CELL

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

(2016) Marten Szibor et al.   Disease Models & Mechanisms

Lipid desaturation - the next step in targeting lipogenesis in cancer?

(2016) Barrie Peck et al.   FEBS Journal

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling

(2016) Sergiy M. Nadtochiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uses and abuses of macropinocytosis

(2016) Gareth Bloomfield et al.   JOURNAL OF CELL SCIENCE

Hypoxia-dependent regulation of inflammatory pathways in immune cells

(2016) Cormac T. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia in health and disease

(2016) Jacques Pouyssegur et al.   MOLECULAR ASPECTS OF MEDICINE

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

(2016) Hyejin Cho et al.   NATURE

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus

(2016) J.J. David Ho et al.   Cell Reports

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation

(2016) Gibok Lee et al.   Scientific Reports

Tumor suppressor functions of BNIP3 and mitophagy

(2015) Aparajita H Chourasia et al.   Autophagy

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling

(2015) M. Carmen Fernández-Agüera et al.   Cell Metabolism

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases

(2015) Suzana Markolovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translating the Untranslated Region

(2015) Johannes Schwerk et al.   JOURNAL OF IMMUNOLOGY

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

(2015) Claire E. J. Moore et al.   MOLECULAR AND CELLULAR BIOLOGY

Suppressors of superoxide production from mitochondrial complex III

(2015) Adam L Orr et al.   Nature Chemical Biology

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

(2015) Patrick H. Maxwell et al.   Nature Reviews Nephrology

Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum

(2015) Jonas J. Staudacher et al.   NUCLEIC ACIDS RESEARCH

Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro

(2015) Brita Singers Sørensen et al.   PLoS One

Higd1ais a positive regulator of cytochromecoxidase

(2015) Takaharu Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF2 -Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

(2015) B. Qiu et al.   Cancer Discovery

HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth

(2015) Kurosh Ameri et al.   Cell Reports

PPARα Protein Expression Was Increased by Four Weeks of Intermittent Hypoxic Training via AMPKα2-Dependent Manner in Mouse Skeletal Muscle

(2015) Ge Li et al.   PLoS One

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

(2014) Meghan B. Azad et al.   Autophagy

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

(2014) Nathalie M. Mazure et al.   Autophagy

Chromatin and oxygen sensing in the context of JmjC histone demethylases

(2014) Alena Shmakova et al.   BIOCHEMICAL JOURNAL

Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression

(2014) J. Uniacke et al.   CANCER RESEARCH

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

(2014) Ramon C. Sun et al.   Cell Metabolism

Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1

(2014) Tianshu Feng et al.   MOLECULAR CELL

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Reciprocal Regulation of Endocytosis and Metabolism

(2014) C. N. Antonescu et al.   Cold Spring Harbor Perspectives in Biology

Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway

(2014) Daan A. Weits et al.   Nature Communications

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

(2014) De Huang et al.   Cell Reports

Superoxide Generated at Mitochondrial Complex III Triggers Acute Responses to Hypoxia in the Pulmonary Circulation

(2013) Gregory B. Waypa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Take the (RN)A-train: Localization of mRNA to the endoplasmic reticulum

(2013) Orit Hermesh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

(2013) R. M. Young et al.   GENES & DEVELOPMENT

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis

(2013) T. S. K. Eisinger-Mathason et al.   Cancer Discovery

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia

(2012) Antonio Romero-Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

(2012) Jun Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

An oxygen-regulated switch in the protein synthesis machinery

(2012) James Uniacke et al.   NATURE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4

(2011) Kevin Foley et al.   BIOCHEMISTRY

The Differential Role of Hif1β/Arnt and the Hypoxic Response in Adipose Function, Fibrosis, and Inflammation

(2011) Kevin Y. Lee et al.   Cell Metabolism

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer

(2011) J. D. Sun et al.   CLINICAL CANCER RESEARCH

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress

(2011) Marion Bouchecareilh et al.   FASEB JOURNAL

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

(2011) P. T. Mungai et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation

(2011) G. A. Gusarova et al.   MOLECULAR AND CELLULAR BIOLOGY

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

(2011) Hyungsoo Kim et al.   MOLECULAR CELL

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization

(2011) Francesco Licausi et al.   NATURE

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants

(2011) Daniel J. Gibbs et al.   NATURE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

(2011) Christian Frezza et al.   PLoS One

Translational control is a major contributor to hypoxia induced gene expression

(2011) Twan van den Beucken et al.   RADIOTHERAPY AND ONCOLOGY

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Hypoxia. 2. Hypoxia regulates cellular metabolism

(2010) William W. Wheaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of IREStrans-acting factors in regulating translation initiation

(2010) Helen A. King et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

(2010) M-P Puisségur et al.   CELL DEATH AND DIFFERENTIATION

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

(2010) Na Zhang et al.   Cell Metabolism

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

(2010) Z Chen et al.   ONCOGENE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Hypoxia-induced BNIP3 expression and mitophagy: in vivo comparison of the rat and the hypoxia-tolerant mole rat, Spalax ehrenbergi

(2009) Mark Band et al.   FASEB JOURNAL

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

(2009) Brooke M. Emerling et al.   FREE RADICAL BIOLOGY AND MEDICINE

Kinetic Evidence for Unique Regulation of GLUT4 Trafficking by Insulin and AMP-activated Protein Kinase Activators in L6 Myotubes

(2009) Daniel J. Fazakerley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism

(2008) Regina M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins

(2008) Matthew E. Cockman et al.   MOLECULAR & CELLULAR PROTEOMICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation

(2008) X. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE