Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia

(2016) Michiel E. Adriaens et al.   Epigenetics & Chromatin

Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells

(2016) Ying Liu et al.   Nature Communications

Hypoxia and Predicting Radiation Response

(2015) Richard P. Hill et al.   SEMINARS IN RADIATION ONCOLOGY

Examining the impact of gene variants on histone lysine methylation

(2014) Capucine Van Rechem et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Targeting histone lysine demethylases — Progress, challenges, and the future

(2014) Cyrille C. Thinnes et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process

(2014) Antero Salminen et al.   CELLULAR SIGNALLING

HIF-1-Dependent Induction of Jumonji Domain-Containing Protein (JMJD) 3 under Hypoxic Conditions

(2014) Ho-Youl Lee et al.   MOLECULES AND CELLS

Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes

(2014) Cláudia Correia et al.   Stem Cell Reviews and Reports

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

(2014) Twan van den Beucken et al.   Nature Communications

Histone variants: emerging players in cancer biology

(2013) Chiara Vardabasso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia-enhanced Derivation of iPSCs from Human Dental Pulp Cells

(2013) K. Iida et al.   JOURNAL OF DENTAL RESEARCH

Histone chaperones in nucleosome assembly and human disease

(2013) Rebecca J Burgess et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hypoxia induces re-entry of committed cells into pluripotency

(2013) Julie Mathieu et al.   STEM CELLS

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase

(2012) Elena M. Sánchez-Fernández et al.   BIOCHEMICAL JOURNAL

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

Chromatin organization and transcriptional regulation

(2012) Michael R Hübner et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo

(2012) K I Ansari et al.   ONCOGENE

MK3 controls Polycomb target gene expression via negative feedback on ERK

(2012) Peggy Prickaerts et al.   Epigenetics & Chromatin

Inhibitors of histone demethylases

(2011) Brian Lohse et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Chromatin states in pluripotent, differentiated, and reprogrammed cells

(2011) Cynthia L Fisher et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The epigenome in early vertebrate development

(2011) Ozren Bogdanović et al.   GENESIS

Acute Versus Chronic Hypoxia: Why a Simplified Classification is Simply Not Enough

(2011) Christine Bayer et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression

(2011) S. M. Welford et al.   MOLECULAR CANCER RESEARCH

ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity

(2011) Matthew D. Young et al.   NUCLEIC ACIDS RESEARCH

The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma

(2011) R Banerjee et al.   ONCOGENE

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase

(2010) X. Zhou et al.   CANCER RESEARCH

The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor   and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth

(2010) J. Yang et al.   CANCER RESEARCH

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Structural insights into histone lysine demethylation

(2010) Haifeng Hou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2

(2010) Klaus Hansen et al.   Epigenetics

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

(2010) Amaya Ortiz-Barahona et al.   NUCLEIC ACIDS RESEARCH

Hypoxia and pluripotency in embryonic and embryonal carcinoma stem cell biology

(2009) Unai Silván et al.   DIFFERENTIATION

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

(2009) M. Barradas et al.   GENES & DEVELOPMENT

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

(2009) K. Agger et al.   GENES & DEVELOPMENT

Predictive chromatin signatures in the mammalian genome

(2009) G. C. Hon et al.   HUMAN MOLECULAR GENETICS

Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response

(2009) Twan van den Beucken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Nucleosome positioning and gene regulation: advances through genomics

(2009) Cizhong Jiang et al.   NATURE REVIEWS GENETICS

In Brief

(2009)   NATURE REVIEWS NEUROSCIENCE

Histone methyltransferases in cancer

(2009) Mareike Albert et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

(2008) Sven Wellmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of gene expression by hypoxia

(2008) Niall Steven Kenneth et al.   BIOCHEMICAL JOURNAL

Global Rank-invariant Set Normalization (GRSN) to reduce systematic distortions in microarray data

(2008) Carl R Pelz et al.   BMC BIOINFORMATICS

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

(2008) P. A.C. Cloos et al.   GENES & DEVELOPMENT

H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome

(2008) F. M. Pauler et al.   GENOME RESEARCH

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

(2008) Amber Buescher Johnson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A model for transmission of the H3K27me3 epigenetic mark

(2008) Klaus H. Hansen et al.   NATURE CELL BIOLOGY

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE