标题
Autophagy and LRRK2 in the Aging Brain
作者
关键词
-
出版物
Frontiers in Neuroscience
Volume 13, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-12-17
DOI
10.3389/fnins.2019.01352
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease
- (2019) Fiona Bonello et al. HUMAN MOLECULAR GENETICS
- Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat
- (2019) Emmanuel Moyse et al. MECHANISMS OF AGEING AND DEVELOPMENT
- LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice
- (2019) Michael X. Henderson et al. Acta Neuropathologica Communications
- Autophagy in cardiomyopathies
- (2019) Antonia T.L. Zech et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)
- (2019) Philip Wing-Lok Ho et al. Autophagy
- LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10
- (2019) Fieke Wauters et al. Autophagy
- LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function
- (2019) Rebecca Wallings et al. HUMAN MOLECULAR GENETICS
- Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression
- (2019) Margie N. Sutton et al. Cancers
- Recent Developments in LRRK2-Targeted Therapy for Parkinson’s Disease
- (2019) Ye Zhao et al. DRUGS
- Autophagy Stimulation Decreases Dopaminergic Neuronal Death Mediated by Oxidative Stress
- (2019) Marcela J. Ramirez-Moreno et al. MOLECULAR NEUROBIOLOGY
- Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress
- (2019) Debapriya Chakraborty et al. Redox Biology
- Selective Autophagy Receptors in Neuronal Health and Disease
- (2019) Owen Conway et al. JOURNAL OF MOLECULAR BIOLOGY
- LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease
- (2019) Emily M. Rocha et al. NEUROBIOLOGY OF DISEASE
- Autophagy and inflammation: A special review issue
- (2018) Vojo Deretic et al. Autophagy
- Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A
- (2018) Marta Pajares et al. Autophagy
- mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition
- (2018) Claudia Manzoni et al. BIOSCIENCE REPORTS
- Targeting autophagy in cancer
- (2018) Angelique V. Onorati et al. CANCER
- The regulation of autophagy by calcium signals: Do we have a consensus?
- (2018) Martin D. Bootman et al. CELL CALCIUM
- LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages
- (2018) Anetta Härtlova et al. EMBO JOURNAL
- Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson’s disease
- (2018) Vassilis E Papadopoulos et al. HUMAN MOLECULAR GENETICS
- AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms
- (2018) Chinwendu Nwadike et al. MOLECULAR AND CELLULAR BIOLOGY
- Autophagy and lysosomal pathways in nervous system disorders
- (2018) Baris Bingol MOLECULAR AND CELLULAR NEUROSCIENCE
- Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum
- (2018) Astrid Kritzinger et al. NEUROBIOLOGY OF AGING
- Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
- (2018) Jason Schapansky et al. NEUROBIOLOGY OF DISEASE
- Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways
- (2018) Yuhei Mizunoe et al. Redox Biology
- Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson’s disease brains with Lewy body pathology
- (2018) Adamantios Mamais et al. BRAIN RESEARCH
- Parkinson's disease: convergence on synaptic homeostasis
- (2018) Sandra‐Fausia Soukup et al. EMBO JOURNAL
- The role of mitochondria in aging
- (2018) Ji Yong Jang et al. JOURNAL OF CLINICAL INVESTIGATION
- Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
- (2018) Barry Boland et al. NATURE REVIEWS DRUG DISCOVERY
- G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
- (2018) Salvatore Novello et al. NEUROBIOLOGY OF DISEASE
- LRRK2 activation in idiopathic Parkinson’s disease
- (2018) Roberto Di Maio et al. Science Translational Medicine
- mTOR-dependent phosphorylation controls TFEB nuclear export
- (2018) Gennaro Napolitano et al. Nature Communications
- Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation
- (2018) Hallvard L. Olsvik et al. Autophagy
- LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase
- (2018) Dong Hwan Ho et al. CELL BIOCHEMISTRY AND FUNCTION
- Leucine rich repeat kinase 2 (LRRK2) GLY2019SER mutation is absent in a second cohort of Nigerian Africans with Parkinson disease
- (2018) Njideka U. Okubadejo et al. PLoS One
- Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis
- (2018) Michaela E. Johnson et al. TRENDS IN NEUROSCIENCES
- The role of monogenic genes in idiopathic Parkinson’s disease
- (2018) Xylena Reed et al. NEUROBIOLOGY OF DISEASE
- Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
- (2017) Andrew B. West EXPERIMENTAL NEUROLOGY
- Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A
- (2017) Jinzhong Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy in the presynaptic compartment in health and disease
- (2017) Vinoy Vijayan et al. JOURNAL OF CELL BIOLOGY
- Evidence for ESCRT- and clathrin-dependent microautophagy
- (2017) Masahide Oku et al. JOURNAL OF CELL BIOLOGY
- Prying into the Prion Hypothesis for Parkinson's Disease
- (2017) Patrik Brundin et al. JOURNAL OF NEUROSCIENCE
- Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease
- (2017) Tim E. Moors et al. Molecular Neurodegeneration
- Autophagy maintains the metabolism and function of young and old stem cells
- (2017) Theodore T. Ho et al. NATURE
- The pharmacological regulation of cellular mitophagy
- (2017) Nikolaos D Georgakopoulos et al. Nature Chemical Biology
- Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
- (2017) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice
- (2017) Emilie Giaime et al. NEURON
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
- (2017) Fiona M. Menzies et al. NEURON
- Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
- (2017) Mathieu Bourdenx et al. PROGRESS IN NEUROBIOLOGY
- Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
- (2017) Martin Steger et al. eLife
- Commentary: Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease
- (2017) Jin-Sung Park et al. Frontiers in Molecular Neuroscience
- Protein Quality Control by Molecular Chaperones in Neurodegeneration
- (2017) Aaron Ciechanover et al. Frontiers in Neuroscience
- Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
- (2017) Annika Höhn et al. Redox Biology
- Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
- (2017) Francesco Longo et al. Acta Neuropathologica Communications
- Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
- (2016) Maria Xilouri et al. Autophagy
- Selective endosomal microautophagy is starvation-inducible in Drosophila
- (2016) Anindita Mukherjee et al. Autophagy
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
- (2016) G. Ito et al. BIOCHEMICAL JOURNAL
- TFEB and TFE3 are novel components of the integrated stress response
- (2016) J. A. Martina et al. EMBO JOURNAL
- (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model
- (2016) Yi-Hsin Weng et al. EXPERIMENTAL NEUROLOGY
- Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts
- (2016) Christiane Ott et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy
- (2016) Cindy Puente et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The lysosome as a command-and-control center for cellular metabolism
- (2016) Chun-Yan Lim et al. JOURNAL OF CELL BIOLOGY
- Transcriptional regulation of mammalian autophagy at a glance
- (2016) Jens Füllgrabe et al. JOURNAL OF CELL SCIENCE
- LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity
- (2016) Senthilkumar S. Karuppagounder et al. JOURNAL OF CHEMICAL NEUROANATOMY
- The Mitochondrial Basis of Aging
- (2016) Nuo Sun et al. MOLECULAR CELL
- LRRK2 at the interface of autophagosomes, endosomes and lysosomes
- (2016) Dorien A. Roosen et al. Molecular Neurodegeneration
- Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease
- (2016) Ludovico Arcuri et al. NEUROBIOLOGY OF DISEASE
- A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals
- (2016) Sandra-Fausia Soukup et al. NEURON
- Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro : A new possible toxic mechanism contributing to Parkinson’s disease
- (2016) Gessica Sala et al. NEUROTOXICOLOGY
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
- (2016) Claudia Manzoni et al. Scientific Reports
- Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1
- (2015) Meredith L. Sosulski et al. AGING CELL
- Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy
- (2015) Yu-Chin Su et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
- (2015) Carlos T. Pineda et al. CELL
- Phosphatidylethanolamine positively regulates autophagy and longevity
- (2015) P Rockenfeller et al. CELL DEATH AND DIFFERENTIATION
- Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
- (2015) João P. L. Daher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
- (2015) Tomonori Kimura et al. JOURNAL OF CELL BIOLOGY
- MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5
- (2015) Catherine L. Nezich et al. JOURNAL OF CELL BIOLOGY
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases
- (2015) Maria Xilouri et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Beclin-1 Deficiency Alters Autophagosome Formation, Lysosome Biogenesis and Enhances Neuronal Vulnerability of HT22 Hippocampal Cells
- (2015) J. Fekadu et al. MOLECULAR NEUROBIOLOGY
- Mutations in LRRK2 potentiate age-related impairment of autophagic flux
- (2015) Shamol Saha et al. Molecular Neurodegeneration
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
- (2015) M. Yue et al. NEUROBIOLOGY OF DISEASE
- Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy
- (2015) Valerie Uytterhoeven et al. NEURON
- Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
- (2015) Reina N. Fuji et al. Science Translational Medicine
- Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
- (2015) Lorraine V. Kalia et al. JAMA Neurology
- Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression
- (2015) Mathieu Bourdenx et al. Acta Neuropathologica Communications
- Regulation of autophagy by amino acids and MTOR-dependent signal transduction
- (2014) Alfred J. Meijer et al. AMINO ACIDS
- Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans
- (2014) Márton L. Tóth et al. Autophagy
- Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease
- (2014) Karen E. Murphy et al. BRAIN
- Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo
- (2014) M. W. Dodson et al. Disease Models & Mechanisms
- Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”
- (2014) Marcello Pinti et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
- (2014) J. Schapansky et al. HUMAN MOLECULAR GENETICS
- Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2)
- (2014) Ryan D. Mills et al. HUMAN MUTATION
- Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents
- (2014) Andrew B. West et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Cargo recognition and trafficking in selective autophagy
- (2014) Alexandra Stolz et al. NATURE CELL BIOLOGY
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration
- (2014) Elpida Tsika et al. NEUROBIOLOGY OF DISEASE
- G2019S LRRK2 mutant fibroblasts from Parkinson’s disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy
- (2014) Sokhna M.S. Yakhine-Diop et al. TOXICOLOGY
- The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling
- (2014) S Saez-Atienzar et al. Cell Death & Disease
- The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy
- (2014) Mónika Lippai et al. Biomed Research International
- LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity
- (2014) Hui-Fang Liu et al. Annals of Clinical and Translational Neurology
- Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation
- (2013) Claudia Manzoni et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of LRRK2 kinase activity stimulates macroautophagy
- (2013) Claudia Manzoni et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
- (2013) Nicholas T. Hertz et al. CELL
- Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
- (2013) Yu-Chin Su et al. HUMAN MOLECULAR GENETICS
- Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation
- (2013) Zhixun Dou et al. MOLECULAR CELL
- Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
- (2013) Andrey S Tsvetkov et al. Nature Chemical Biology
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases
- (2013) Adamantios Mamais et al. NEUROBIOLOGY OF DISEASE
- Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs
- (2013) Marco A. S. Baptista et al. PLoS One
- Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy
- (2013) Y. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Look people, “Atg” is an abbreviation for “autophagy-related.” That’s it.
- (2012) Daniel J Klionsky Autophagy
- LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy
- (2012) Patricia Gómez-Suaga et al. Autophagy
- A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling
- (2012) Patricia Gómez-Suaga et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD
- (2012) C-Y Chen et al. CELL DEATH AND DIFFERENTIATION
- The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
- (2012) José M. Bravo-San Pedro et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
- (2012) Adriana Sánchez-Danés et al. EMBO Molecular Medicine
- PINK1- and Parkin-mediated mitophagy at a glance
- (2012) Seok Min Jin et al. JOURNAL OF CELL SCIENCE
- MPTP modulates hippocampal synaptic transmission and activity-dependent synaptic plasticity via dopamine receptors
- (2012) GuoQi Zhu et al. JOURNAL OF NEUROCHEMISTRY
- AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease
- (2012) C.-H. Ng et al. JOURNAL OF NEUROSCIENCE
- LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
- (2012) Kelly M Hinkle et al. Molecular Neurodegeneration
- Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
- (2012) Youren Tong et al. Molecular Neurodegeneration
- Regulation of Presynaptic Neurotransmission by Macroautophagy
- (2012) Daniela Hernandez et al. NEURON
- Inhibitory effect of dietary lipids on chaperone-mediated autophagy
- (2012) J. A. Rodriguez-Navarro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chaperone-mediated autophagy: a unique way to enter the lysosome world
- (2012) Susmita Kaushik et al. TRENDS IN CELL BIOLOGY
- Morphological and biochemical studies on aging and autophagy
- (2011) Rita Rezzani et al. AGEING RESEARCH REVIEWS
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Microautophagy of Cytosolic Proteins by Late Endosomes
- (2011) Ranjit Sahu et al. DEVELOPMENTAL CELL
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
- (2011) M. W. Dodson et al. HUMAN MOLECULAR GENETICS
- Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
- (2011) Patricia Gómez-Suaga et al. HUMAN MOLECULAR GENETICS
- Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
- (2011) Mansoureh Hakimi et al. JOURNAL OF NEURAL TRANSMISSION
- Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies
- (2011) Shinji Higashi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers
- (2011) C. Marras et al. NEUROLOGY
- Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
- (2011) David Ramonet et al. PLoS One
- Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation
- (2011) Jonathan Thévenet et al. PLoS One
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
- (2010) Lydia Alvarez-Erviti et al. ARCHIVES OF NEUROLOGY
- With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
- (2010) Pankaj Kapahi et al. Cell Metabolism
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- Prion-like transmission of protein aggregates in neurodegenerative diseases
- (2010) Patrik Brundin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease
- (2010) Chen Yao et al. NEUROBIOLOGY OF DISEASE
- Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress
- (2010) M. Klinkenberg et al. NEUROSCIENCE
- Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
- (2010) Leslie Crews et al. PLoS One
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagosome Formation Depends on the Small GTPase Rab1 and Functional ER Exit Sites
- (2010) Felipe Carlos Martín Zoppino et al. TRAFFIC
- GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
- (2010) Yulan Xiong et al. PLoS Genetics
- Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging
- (2009) Alexei Terman et al. ANTIOXIDANTS & REDOX SIGNALING
- Molecular pathogenesis of Parkinson disease: insights from genetic studies
- (2009) Thomas Gasser EXPERT REVIEWS IN MOLECULAR MEDICINE
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism
- (2009) Jozsef Gal et al. JOURNAL OF NEUROCHEMISTRY
- Impaired dopamine release and synaptic plasticity in the striatum ofParkin−/− mice
- (2009) Tohru Kitada et al. JOURNAL OF NEUROCHEMISTRY
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
- (2009) Yanping Li et al. NATURE NEUROSCIENCE
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
- (2009) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila melanogaster
- (2009) Richard C. Grandison et al. PLoS One
- Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
- (2009) A. Ben-Zvi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Gene Network Regulating Lysosomal Biogenesis and Function
- (2009) Marco Sardiello et al. SCIENCE
- mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex
- (2009) E. Y. Chan Science Signaling
- Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
- (2008) Yuzuru Imai et al. EMBO JOURNAL
- FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
- (2008) Taichi Hara et al. JOURNAL OF CELL BIOLOGY
- Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
- (2008) Marta Martinez-Vicente et al. JOURNAL OF CLINICAL INVESTIGATION
- Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
- (2008) Edward D. Plowey et al. JOURNAL OF NEUROCHEMISTRY
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
- (2008) C. A. Gautier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started