The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy

Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 inDrosophila

(2014) Péter Nagy et al.   Autophagy

Musical chairs during mitophagy

(2014) Jörn Dengjel et al.   Autophagy

iLIR

(2014) Ioanna Kalvari et al.   Autophagy

An inhibition of p62/SQSTM1 caused autophagic cell death of several human carcinoma cells

(2014) Kaito Nihira et al.   CANCER SCIENCE

Solution Structure of the Ubiquitin-associated (UBA) Domain of Human Autophagy Receptor NBR1 and Its Interaction with Ubiquitin and Polyubiquitin

(2014) Erik Walinda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila

(2014) Szabolcs Takáts et al.   MOLECULAR BIOLOGY OF THE CELL

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Selective autophagy goes exclusive

(2014) Terje Johansen et al.   NATURE CELL BIOLOGY

Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane–cargo apposition during selective autophagy

(2014) Justyna Sawa-Makarska et al.   NATURE CELL BIOLOGY

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

(2014) Daniel J Klionsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1  expression

(2014) J.-Y. Choe et al.   RHEUMATOLOGY

Autophagy inDrosophila: From Historical Studies to Current Knowledge

(2014) Nitha C. Mulakkal et al.   Biomed Research International

The Putative HORMA Domain Protein Atg101 Dimerizes and Is Required for Starvation-Induced and Selective Autophagy inDrosophila

(2014) Krisztina Hegedűs et al.   Biomed Research International

Significant role of PB1 and UBA domains in multimerization of Joka2, a selective autophagy cargo receptor from tobacco

(2014) Katarzyna Zientara-Rytter et al.   Frontiers in Plant Science

Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro

(2013) Liang Zhou et al.   ACTA PHARMACOLOGICA SINICA

Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (syntaxin 17)-containing SNARE complex in autophagosome fusion with endosomes and lysosomes

(2013) Krisztina Hegedűs et al.   Autophagy

Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling

(2013) Junyan Shi et al.   Autophagy

Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

(2013) Péter Lőw et al.   BMC CELL BIOLOGY

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

The role of ‘eat-me’ signals and autophagy cargo receptors in innate immunity

(2013) Keith B. Boyle et al.   CURRENT OPINION IN MICROBIOLOGY

Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11

(2013) Jean-Claude Farré et al.   EMBO REPORTS

Autophagy as a defence against intracellular pathogens

(2013) Tom Wileman   Essays in Biochemistry

SQSTM1/p62/A170 regulates the severity ofLegionella pneumophilapneumonia by modulating inflammasome activity

(2013) Shigeo Ohtsuka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Different effects ofAtg2andAtg18mutations on Atg8a and Atg9 trafficking during starvation in Drosophila

(2013) Péter Nagy et al.   FEBS LETTERS

p62/Sequestosome-1 Up-regulation Promotes ABT-263-induced Caspase-8 Aggregation/Activation on the Autophagosome

(2013) Shengbing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

(2013) Naonobu Fujita et al.   JOURNAL OF CELL BIOLOGY

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function inDrosophila

(2013) Szabolcs Takáts et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

NBR1-Mediated Selective Autophagy Targets Insoluble Ubiquitinated Protein Aggregates in Plant Stress Responses

(2013) Jie Zhou et al.   PLoS Genetics

Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila

(2012) Balázs Érdi et al.   Autophagy

Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments

(2012) Gábor Juhász   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells

(2012) Ai Takeda-Watanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

(2012) C-P Chang et al.   CELL DEATH AND DIFFERENTIATION

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex

(2012) Endalkachew Ashenafi Alemu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Interactive Web-Based Pointillist Visualization of Hydrogenic Orbitals Using Jmol

(2012) Shane P. Tully et al.   JOURNAL OF CHEMICAL EDUCATION

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

(2012) Chinatsu Otomo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila

(2012) Karolina Pircs et al.   PLoS One

Keap1 degradation by autophagy for the maintenance of redox homeostasis

(2012) K. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p62: a versatile multitasker takes on cancer

(2012) Jorge Moscat et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Mitophagy: A Complex Mechanism of Mitochondrial Removal

(2011) Ivana Novak   ANTIOXIDANTS & REDOX SIGNALING

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

(2011) Bryan J. Bartlett et al.   Autophagy

TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS)

(2011) Ken-Ichi Fujita et al.   Autophagy

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20

(2011) Megumi Inomata et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Constructing and decoding unconventional ubiquitin chains

(2011) Christian Behrends et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

(2010) Marisa Ponpuak et al.   IMMUNITY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Origin and function of ubiquitin-like proteins

(2009) Mark Hochstrasser   NATURE

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE