Autophagy in the presynaptic compartment in health and disease

Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons

(2017) Mian Cao et al.   NEURON

Bassoon Controls Presynaptic Autophagy through Atg5

(2017) Nathan D. Okerlund et al.   NEURON

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors

(2016) Ashley A. George et al.   BIOESSAYS

Mechanisms of neuronal homeostasis: Autophagy in the axon

(2016) Sandra Maday   BRAIN RESEARCH

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

(2016) Andrea K.H. Stavoe et al.   DEVELOPMENTAL CELL

Compartment-Specific Regulation of Autophagy in Primary Neurons

(2016) Sandra Maday et al.   JOURNAL OF NEUROSCIENCE

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model

(2016) Cristian A. Lasagna-Reeves et al.   NEURON

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals

(2016) Sandra-Fausia Soukup et al.   NEURON

Identification of a novel homozygous mutation Arg459Pro in SYNJ1 gene of an Indian family with autosomal recessive juvenile Parkinsonism

(2016) Laxmi Kirola et al.   PARKINSONISM & RELATED DISORDERS

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

(2016) John D. Murdoch et al.   Cell Reports

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

(2016) Varun K. Gupta et al.   PLOS BIOLOGY

A mathematical model explains saturating axon guidance responses to molecular gradients

(2016) Huyen Nguyen et al.   eLife

Answering the ultimate question “What is the Proximal Cause of Aging?”

(2016) Mikhail V. Blagosklonny   Aging-US

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Presynaptic active zones in invertebrates and vertebrates

(2015) F. Ackermann et al.   EMBO REPORTS

The Regulation of Synaptic Protein Turnover

(2015) Beatriz Alvarez-Castelao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

(2015) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

Control of Autophagosome Axonal Retrograde Flux by Presynaptic Activity Unveiled Using Botulinum Neurotoxin Type A

(2015) Tong Wang et al.   JOURNAL OF NEUROSCIENCE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

(2015) Valerie Uytterhoeven et al.   NEURON

Autophagy in synaptic development, function, and pathology

(2015) Dan-Na Shen et al.   Neuroscience Bulletin

The GTPase Rab26 links synaptic vesicles to the autophagy pathway

(2015) Beyenech Binotti et al.   eLife

Communication breakdown: The impact of ageing on synapse structure

(2014) Ronald S. Petralia et al.   AGEING RESEARCH REVIEWS

Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway

(2014) Sandra Maday et al.   DEVELOPMENTAL CELL

Synaptic vesicle recycling: steps and principles

(2014) S. O. Rizzoli   EMBO JOURNAL

Reduced synaptic vesicle protein degradation at lysosomes curbsTBC1D24/sky-induced neurodegeneration

(2014) Ana Clara Fernandes et al.   JOURNAL OF CELL BIOLOGY

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

(2014) A. M. Arranz et al.   JOURNAL OF CELL SCIENCE

Upregulation of Parkin in Endophilin Mutant Mice

(2014) Mian Cao et al.   JOURNAL OF NEUROSCIENCE

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARK20 caused by SYNJ1 homozygous Arg258Gln mutation in a new Italian family

(2014) Simone Olgiati et al.   NEUROGENETICS

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Putting a finishing touch on GECIs

(2014) Tobias Rose et al.   Frontiers in Molecular Neuroscience

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Recent advances in optogenetics and pharmacogenetics

(2013) Gary Aston-Jones et al.   BRAIN RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

Mutation in theSYNJ1Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism

(2013) Marialuisa Quadri et al.   HUMAN MUTATION

The Sac1 Domain ofSYNJ1Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures

(2013) Catharine E. Krebs et al.   HUMAN MUTATION

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function inDrosophila

(2013) Szabolcs Takáts et al.   JOURNAL OF CELL BIOLOGY

A molecular machine for neurotransmitter release: synaptotagmin and beyond

(2013) Thomas C Südhof   NATURE MEDICINE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

(2013) Varun K Gupta et al.   NATURE NEUROSCIENCE

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Seeing the Unseen

(2013) Subhojit Roy   NEUROSCIENTIST

Genetics of Parkinson's disease – state of the art, 2013

(2013) Vincenzo Bonifati   PARKINSONISM & RELATED DISORDERS

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Sonic hedgehog promotes autophagy in hippocampal neurons

(2013) R. S. Petralia et al.   Biology Open

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Modulating macroautophagy: a neuronal perspective

(2012) Christopher W Johnson et al.   Future Medicinal Chemistry

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Neuronal Stimulation Induces Autophagy in Hippocampal Neurons That Is Involved in AMPA Receptor Degradation after Chemical Long-Term Depression

(2012) M. Shehata et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy

(2012) Sulochanadevi Baskaran et al.   MOLECULAR CELL

Insights into CNS ageing from animal models of senescence

(2012) Mark Yeoman et al.   NATURE REVIEWS NEUROSCIENCE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

(2012) Samer Matta et al.   NEURON

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Loss of Skywalker Reveals Synaptic Endosomes as Sorting Stations for Synaptic Vesicle Proteins

(2011) Valerie Uytterhoeven et al.   CELL

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model

(2011) Ana Roscic et al.   JOURNAL OF NEUROCHEMISTRY

Age-Related Alterations in Neurons of the Mouse Retina

(2011) M. A. Samuel et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool

(2011) G. Piccoli et al.   JOURNAL OF NEUROSCIENCE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease

(2011) Baris Bingol et al.   NEURON

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Structural and synaptic plasticity in stress-related disorders

(2011) Daniel J. Christoffel et al.   REVIEWS IN THE NEUROSCIENCES

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Short-term fasting induces profound neuronal autophagy

(2010) Mehrdad Alirezaei et al.   Autophagy

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Common Mechanisms of Synaptic Plasticity in Vertebrates and Invertebrates

(2010) David L. Glanzman   CURRENT BIOLOGY

Age-associated alterations of the neuromuscular junction

(2010) Youngmok C. Jang et al.   EXPERIMENTAL GERONTOLOGY

Age-Related Deterioration of Rod Vision in Mice

(2010) A. V. Kolesnikov et al.   JOURNAL OF NEUROSCIENCE

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

(2010) Jonathan H Fox et al.   Molecular Neurodegeneration

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

(2010) Troy T. Rohn et al.   NEUROBIOLOGY OF DISEASE

Synaptic dysfunction in genetic models of Parkinson's disease: A role for autophagy?

(2010) Edward D. Plowey et al.   NEUROBIOLOGY OF DISEASE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise

(2010) G. Valdez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Regulation of membrane biogenesis in autophagy via PI3P dynamics

(2010) Takeshi Noda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy promotes synapse development inDrosophila

(2009) Wei Shen et al.   JOURNAL OF CELL BIOLOGY

Unc-51 Controls Active Zone Density and Protein Composition by Downregulating ERK Signaling

(2009) Y. P. Wairkar et al.   JOURNAL OF NEUROSCIENCE

SH3 Domains from a Subset of BAR Proteins Define a Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination

(2009) Jean-François Trempe et al.   MOLECULAR CELL

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Caloric restriction improves memory in elderly humans

(2009) A. V. Witte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrient Deprivation Induces Neuronal Autophagy and Implicates Reduced Insulin Signaling in Neuroprotective Autophagy Activation

(2008) Jessica E. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling inDrosophila

(2008) Gábor Juhász et al.   JOURNAL OF CELL BIOLOGY

Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake

(2008) Jaroslaw Kasprowicz et al.   JOURNAL OF CELL BIOLOGY

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

(2008) Fiona Pickford et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

High frequency action potential bursts (≥ 100 Hz) in L2/3 and L5B thick tufted neurons in anaesthetized and awake rat primary somatosensory cortex

(2008) C. P. J. De Kock et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice

(2008) Yu-shin Sou et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Age-dependent remodelling of retinal circuitry

(2007) E. Terzibasi et al.   NEUROBIOLOGY OF AGING