Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

Defining the consequences of genetic variation on a proteome-wide scale

(2016) Joel M. Chick et al.   NATURE

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

(2016) Christian Münch et al.   NATURE

Synchronized mitochondrial and cytosolic translation programs

(2016) Mary T. Couvillion et al.   NATURE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systems proteomics of liver mitochondria function

(2016) E. G. Williams et al.   SCIENCE

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Joint mouse–human phenome-wide association to test gene function and disease risk

(2016) Xusheng Wang et al.   Nature Communications

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness

(2015) Uwe Richter et al.   JOURNAL OF CELL BIOLOGY

Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response

(2015) Sebastien Michel et al.   MITOCHONDRION

Proteome-wide quantitative multiplexed profiling of protein expression: carbon-source dependency in Saccharomyces cerevisiae

(2015) Joao A. Paulo et al.   MOLECULAR BIOLOGY OF THE CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

(2015) Carmela Sidrauski et al.   eLife

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart

(2014) Sukru Anil Dogan et al.   Cell Metabolism

Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome System

(2014) Alexandra Segref et al.   Cell Metabolism

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

(2014) M. J. Baker et al.   EMBO JOURNAL

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

(2014) Pénélope A. Andreux et al.   Scientific Reports

ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

(2014) Pedro M. Quirós et al.   Cell Reports

A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels

(2014) Nathan J. Lanning et al.   Cell Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

(2013) T. Kelly Rainbolt et al.   Cell Metabolism

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

A Small Molecule Inhibitor of Redox-Regulated Protein Translocation into Mitochondria

(2013) Deepa V. Dabir et al.   DEVELOPMENTAL CELL

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

(2013) S. Gispert et al.   HUMAN MOLECULAR GENETICS

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway

(2013) M. Rauthan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

AMPK and GCN2–ATF4 signal the repression of mitochondria in colon cancer cells

(2012) Inmaculada Martínez-Reyes et al.   BIOCHEMICAL JOURNAL

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives

(2012) S. H. Bernstein et al.   BLOOD

Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

(2012) Pénélope A. Andreux et al.   CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

(2012) Pedro M Quirós et al.   EMBO JOURNAL

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

(2012) David Vilchez et al.   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection–Time-of-Flight Mass Spectrometry

(2011) Tobias Fuhrer et al.   ANALYTICAL CHEMISTRY

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells

(2008) D. Krige et al.   CANCER RESEARCH

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

(2008) N Moisoi et al.   CELL DEATH AND DIFFERENTIATION

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Dissection of a QTL Hotspot on Mouse Distal Chromosome 1 that Modulates Neurobehavioral Phenotypes and Gene Expression

(2008) Khyobeni Mozhui et al.   PLoS Genetics