Uses and abuses of macropinocytosis

Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells

(2016) Mickaël M. Ménager et al.   CELL

Selective localization of myosin-I proteins in macropinosomes and actin waves

(2016) Hanna Brzeska et al.   Cytoskeleton

The Large Marseillevirus Explores Different Entry Pathways by Forming Giant Infectious Vesicles

(2016) Thalita Souza Arantes et al.   JOURNAL OF VIROLOGY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Efficient Intracellular Delivery of Native Proteins

(2015) Diego S. D’Astolfo et al.   CELL

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Neuropilin Functions as an Essential Cell Surface Receptor

(2015) Hou-Fu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

(2015) Sei Yoshida et al.   JOURNAL OF CELL BIOLOGY

An Acto-Myosin II Constricting Ring Initiates the Fission of Activity-Dependent Bulk Endosomes in Neurosecretory Cells

(2015) R. S. Gormal et al.   JOURNAL OF NEUROSCIENCE

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

(2015) Rafaa Zeineddine et al.   Molecular Neurodegeneration

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Viral apoptotic mimicry

(2015) Ali Amara et al.   NATURE REVIEWS MICROBIOLOGY

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Amino acid management in cancer

(2015) Zhi-Yang Tsun et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Arf GTPase-Activating Protein Family Is Exploited by Salmonella enterica Serovar Typhimurium To Invade Nonphagocytic Host Cells

(2015) Anthony C. Davidson et al.   mBio

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

(2015) Mélanie Chabaud et al.   Nature Communications

RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development

(2015) Direna Alonso-Curbelo et al.   Oncotarget

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

(2015) Weihao Tang et al.   Molecular Brain

Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium

(2015) Gareth Bloomfield et al.   eLife

The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases

(2015) Rafaa Zeineddine et al.   Frontiers in Physiology

Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen presentation in dendritic cells

(2015) Zhenzhen Liu et al.   Frontiers in Physiology

Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic cell-penetrating peptides

(2015) H.-B. Pang et al.   Science Advances

Dynamics of Actin Waves on Patterned Substrates: A Quantitative Analysis of Circular Dorsal Ruffles

(2015) Erik Bernitt et al.   PLoS One

Methuosis

(2014) William A. Maltese et al.   AMERICAN JOURNAL OF PATHOLOGY

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells

(2014) Yanrong Qian et al.   CANCER LETTERS

RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

(2014) Satish Srinivas Kitambi et al.   CELL

Phosphoinositides and engulfment

(2014) Joel A. Swanson   CELLULAR MICROBIOLOGY

Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling

(2014) J. Clark et al.   EMBO JOURNAL

PIP3-dependent macropinocytosis is incompatible with chemotaxis

(2014) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread

(2014) Mark A. Czuczman et al.   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis

(2014) M. Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability

(2014) Hong-Bo Pang et al.   Nature Communications

Inflammatory Stimuli Reprogram Macrophage Phagocytosis to Macropinocytosis for the Rapid Elimination of Pathogens

(2014) Somdeb BoseDasgupta et al.   PLoS Pathogens

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

(2014) Youhei Egami et al.   Frontiers in Physiology

Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells

(2013) Vinod Sundaramoorthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The ins-and-outs of endosomal antigens for cross-presentation

(2013) Verena Schuette et al.   CURRENT OPINION IN IMMUNOLOGY

Macrophages clean up: efferocytosis and microbial control

(2013) Constance J Martin et al.   CURRENT OPINION IN MICROBIOLOGY

Exploiting the bad eating habits of Ras-driven cancers

(2013) E. White   GENES & DEVELOPMENT

Two distinct functions for PI3-kinases in macropinocytosis

(2013) O. Hoeller et al.   JOURNAL OF CELL SCIENCE

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Ultrafast endocytosis at mouse hippocampal synapses

(2013) Shigeki Watanabe et al.   NATURE

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctions

(2013) Shigeki Watanabe et al.   eLife

Gulping rather than sipping: macropinocytosis as a way of virus entry

(2012) Jason Mercer et al.   CURRENT OPINION IN MICROBIOLOGY

Early evolution of eukaryote feeding modes, cell structural diversity, and classification of the protozoan phyla Loukozoa, Sulcozoa, and Choanozoa

(2012) Thomas Cavalier-Smith   EUROPEAN JOURNAL OF PROTISTOLOGY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salmonella infects B cells by macropinocytosis and formation of spacious phagosomes but does not induce pyroptosis in favor of its survival

(2012) Roberto Rosales-Reyes et al.   MICROBIAL PATHOGENESIS

Myosin I Links PIP3 Signaling to Remodeling of the Actin Cytoskeleton in Chemotaxis

(2012) C.-L. Chen et al.   Science Signaling

A growth factor signaling cascade confined to circular ruffles in macrophages

(2012) T. P. Welliver et al.   Biology Open

Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells

(2011) D. Le Roux et al.   BLOOD

T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

(2011) Nuria Martínez-Martín et al.   IMMUNITY

Ruffles limit diffusion in the plasma membrane during macropinosome formation

(2011) T. P. Welliver et al.   JOURNAL OF CELL SCIENCE

Syntaxin 1B Suppresses Macropinocytosis and Semaphorin 3A-Induced Growth Cone Collapse

(2011) H. Kabayama et al.   JOURNAL OF NEUROSCIENCE

A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells

(2011) Jean H Overmeyer et al.   Molecular Cancer

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism

(2010) E. M. Reyes-Reyes et al.   CANCER RESEARCH

Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry

(2010) J. Mercer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages

(2009) S. Yoshida et al.   JOURNAL OF CELL SCIENCE

The molecular physiology of activity-dependent bulk endocytosis of synaptic vesicles

(2009) Emma L. Clayton et al.   JOURNAL OF NEUROCHEMISTRY

Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells

(2009) Chunhui Li et al.   JOURNAL OF NEUROCHEMISTRY

Negative Guidance Factor-Induced Macropinocytosis in the Growth Cone Plays a Critical Role in Repulsive Axon Turning

(2009) A. L. Kolpak et al.   JOURNAL OF NEUROSCIENCE

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC

Bulk Synaptic Vesicle Endocytosis Is Rapidly Triggered during Strong Stimulation

(2008) E. L. Clayton et al.   JOURNAL OF NEUROSCIENCE

Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis

(2008) J. H. Overmeyer et al.   MOLECULAR CANCER RESEARCH

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Unique Platform for H-Ras Signaling Involving Clathrin-independent Endocytosis

(2007) Natalie Porat-Shliom et al.   MOLECULAR BIOLOGY OF THE CELL